Protein Alignment prage and panl-2

DIOPT Version :10

• Sequence 1: NP_001188528.1
• Gene: prage / 31136
• FlyBaseID: FBgn0283741
• Length: 852
• Species: Drosophila melanogaster
• Sequence 2: NP_498519.1
• Gene: panl-2 / 175974
• WormBaseID: WBGene00017951
• Length: 1131
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 140/710 - (19%)
• Similarity: 243/710 - (34%)
• Gaps: 217/710 - (30%)

  Fly   302 QTRNPDHNGQRTGAATPCTGQKAKQGNAK---WRQQQPNPSSNN--QQQQMQQQMQQQKRGR--N 359
            |.:||..|            .|.|:.|..   :.|::...:||:  .:::..|:|::.|..:  .
 Worm   405 QIKNPRIN------------SKLKRHNIVPYFFEQEELIEASNDHGSKEEAPQEMKRIKVSKLYK 457

  Fly   360 KKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSAT------------TSATSSPTNS 412
            |:|      :|.|......|:||.:|.::.:.:.:...|..:|            .:.:.||..|
 Worm   458 KRP------LIVNQVPARRGNSQDETQETYTWNIIRHVTMQSTHGMNLVANTLVQVAYSLSPIRS 516

  Fly   413 P--------------------TSYPRANG-NRKRIEAALEWRREQELGRQNANFLVPPLRQYEQL 456
            .                    |::....| |...:...|.|...:......|..::...:|..:.
 Worm   517 IVLRHICTEDSCITCELHFLFTAFSSKIGDNSGMLTNNLAWALARNGVSLKAGGVLSATQQIIKT 581

  Fly   457 EFDD-------KTVVQQLRRHI-------------IDNHLLRVYGFPV---------DSVVH--- 489
            ..||       .::..:..||:             :.:|||::...||         :..:|
 Worm   582 VIDDVARTDASGSICSKFDRHLRCIRCRGLQQQESVTDHLLKLNYAPVYQASLCQLIEKSLHIGD 646

  Fly   490 -EGAIEIFKC--MPHMSFAAALAETAQAVTVINYHDGLTN----------RAEEEVANSTDSGNS 541
             .|.||...|  |..|.....:.|.:..:.:.      ||          |.:..:......||.
 Worm   647 DSGEIECEDCKQMSRMECKRKVRELSPVLLID------TNASSNGFVEFWRRQLSLFERKPGGNR 705

  Fly   542 S------PQSLDSESGGEWSGSECESSNSSSSSAG------EAALGLE----LKYCHFVPVERSL 590
            |      |:| .||......|::|.:..:.....|      |....||    .::.|::| .|..
 Worm   706 SSALGTVPES-PSEKKNCRFGTDCRNKKTCKFVHGLVDWPAEQTKLLEDVDLPEWAHYIP-SRIA 768

  Fly   591 SKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGR--------------------- 634
            ::.|....|...|.:|.    .::|......:.......|.:|.
 Worm   769 AQLCEGIVRLSDVSDLP----DYDEPSAVIYELDAMIHAVGNGENDVNWTHPVTLLRESPVISSS 829

  Fly   635 WTCCNEGEESSPGCCLGD---RHV---WS-GSVVGVNGPYYD------------FVRTEHRGSG- 679
            ||..||...|.    |.|   ||:   |. .:::......:|            |:..|:..|.
 Worm   830 WTLINEQLVSR----LHDHEARHIDGRWKLPALLAYKKKNFDVKTSEDIISNDLFLAEENLASNG 890

  Fly   680 ------------EDEPAVYALDCE--------MSYTGRGLD---VTKVSLVALNGQ-LVYEHFVR 720
                        ..|..:..||.|        :.:.|:.:.   |.:.|.|...|: ::::..|:
 Worm   891 MTSLAVQSLEELPKEKELVGLDAEFIKIKTDLLEFDGKTVQMRAVGRASCVDSTGERIIFDDHVK 955

  Fly   721 PVCD--IIDYNTQYSGITETDLC--SGAKSLAEVQRDLLQ---LITADTILIGHGLENDLRALRL 778
            ...|  ::||.|::|||.:.|||  :..|.|...:|.||:   ||......:||.|.||...|.
 Worm   956 LTDDVEVVDYLTKFSGIVKADLCPTTSEKYLTTHKRLLLRMHVLIQRGVTFVGHALHNDFTVLN- 1019

  Fly   779 VH---NTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMEL 835
            ||   :.:||| ::.... |.....:|:.|.|..|...||    ...|.|..|:|..::|
 Worm  1020 VHVAESQIIDT-VTLMRL-GTQRMLSLQFLVKEILGETIQ----MEAHDSVVDARYALKL 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:473070	8/56 (14%)
		REX1_like	686..837	CDD:99848	49/172 (28%)
panl-2	NP_498519.1	WD40	28..324	CDD:475233
		UCH_1	494..>693	CDD:463872	31/204 (15%)
		PAN2_exo	909..1075	CDD:99846	49/172 (28%)