DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prage and panl-2

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_498519.1	Gene:	panl-2 / 175974	WormBaseID:	WBGene00017951	Length:	1131	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	140/710 - (19%)
Similarity:	243/710 - (34%)	Gaps:	217/710 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 QTRNPDHNGQRTGAATPCTGQKAKQGNAK---WRQQQPNPSSNN--QQQQMQQQMQQQKRGR--N 359
            |.:||..|            .|.|:.|..   :.|::...:||:  .:::..|:|::.|..:  .
Worm   405 QIKNPRIN------------SKLKRHNIVPYFFEQEELIEASNDHGSKEEAPQEMKRIKVSKLYK 457

  Fly   360 KKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSSALSSPTSSAT------------TSATSSPTNS 412
            |:|      :|.|......|:||.:|.::.:.:.:...|..:|            .:.:.||..|
Worm   458 KRP------LIVNQVPARRGNSQDETQETYTWNIIRHVTMQSTHGMNLVANTLVQVAYSLSPIRS 516

  Fly   413 P--------------------TSYPRANG-NRKRIEAALEWRREQELGRQNANFLVPPLRQYEQL 456
            .                    |::....| |...:...|.|...:......|..::...:|..:.
Worm   517 IVLRHICTEDSCITCELHFLFTAFSSKIGDNSGMLTNNLAWALARNGVSLKAGGVLSATQQIIKT 581

  Fly   457 EFDD-------KTVVQQLRRHI-------------IDNHLLRVYGFPV---------DSVVH--- 489
            ..||       .::..:..||:             :.:|||::...||         :..:|
Worm   582 VIDDVARTDASGSICSKFDRHLRCIRCRGLQQQESVTDHLLKLNYAPVYQASLCQLIEKSLHIGD 646

  Fly   490 -EGAIEIFKC--MPHMSFAAALAETAQAVTVINYHDGLTN----------RAEEEVANSTDSGNS 541
             .|.||...|  |..|.....:.|.:..:.:.      ||          |.:..:......||.
Worm   647 DSGEIECEDCKQMSRMECKRKVRELSPVLLID------TNASSNGFVEFWRRQLSLFERKPGGNR 705

  Fly   542 S------PQSLDSESGGEWSGSECESSNSSSSSAG------EAALGLE----LKYCHFVPVERSL 590
            |      |:| .||......|::|.:..:.....|      |....||    .::.|::| .|..
Worm   706 SSALGTVPES-PSEKKNCRFGTDCRNKKTCKFVHGLVDWPAEQTKLLEDVDLPEWAHYIP-SRIA 768

  Fly   591 SKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRYYDGVSHGR--------------------- 634
            ::.|....|...|.:|.    .::|......:.......|.:|.
Worm   769 AQLCEGIVRLSDVSDLP----DYDEPSAVIYELDAMIHAVGNGENDVNWTHPVTLLRESPVISSS 829

  Fly   635 WTCCNEGEESSPGCCLGD---RHV---WS-GSVVGVNGPYYD------------FVRTEHRGSG- 679
            ||..||...|.    |.|   ||:   |. .:::......:|            |:..|:..|.
Worm   830 WTLINEQLVSR----LHDHEARHIDGRWKLPALLAYKKKNFDVKTSEDIISNDLFLAEENLASNG 890

  Fly   680 ------------EDEPAVYALDCE--------MSYTGRGLD---VTKVSLVALNGQ-LVYEHFVR 720
                        ..|..:..||.|        :.:.|:.:.   |.:.|.|...|: ::::..|:
Worm   891 MTSLAVQSLEELPKEKELVGLDAEFIKIKTDLLEFDGKTVQMRAVGRASCVDSTGERIIFDDHVK 955

  Fly   721 PVCD--IIDYNTQYSGITETDLC--SGAKSLAEVQRDLLQ---LITADTILIGHGLENDLRALRL 778
            ...|  ::||.|::|||.:.|||  :..|.|...:|.||:   ||......:||.|.||...|.
Worm   956 LTDDVEVVDYLTKFSGIVKADLCPTTSEKYLTTHKRLLLRMHVLIQRGVTFVGHALHNDFTVLN- 1019

  Fly   779 VH---NTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMEL 835
            ||   :.:||| ::.... |.....:|:.|.|..|...||    ...|.|..|:|..::|
Worm  1020 VHVAESQIIDT-VTLMRL-GTQRMLSLQFLVKEILGETIQ----MEAHDSVVDARYALKL 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	8/56 (14%)
		DnaQ	675..>837	CDD:223916	51/196 (26%)
		REX1_like	686..837	CDD:99848	49/172 (28%)
panl-2	NP_498519.1	WD40	<17..322	CDD:225201
		WD40	28..324	CDD:295369
		Peptidase_C19	493..>613	CDD:271592	15/119 (13%)
		PAN2_exo	909..1075	CDD:99846	49/172 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810