DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment prage and XB5934250

DIOPT Version :9

Sequence 1:	NP_001188528.1	Gene:	prage / 31136	FlyBaseID:	FBgn0283741	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001090720.1	Gene:	XB5934250 / 100036702	XenbaseID:	XB-GENE-5934251	Length:	1026	Species:	Xenopus tropicalis

Alignment Length:	1050	Identity:	247/1050 - (23%)
Similarity:	389/1050 - (37%)	Gaps:	331/1050 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VAAIKRKIDPEQQQQRKQHRSNILGCNKSSSINCSSINGDNRHLQRQQGKMYYN----------- 71
            :.|:|.::: |:|::...:::.|...:|.:.:..|:.| ..|.|..|.|.:..|
Frog    79 IEAVKNEVE-EKQKKLLLYKNGIHSTSKVTPLTDSNSN-IARGLDMQDGDLKSNVHANISKNGPS 141

  Fly    72 -----------------------------------------SSSRPF---------WRKCRSAAP 86
                                                     .|.||.         .:|.|:|:|
Frog   142 FERTKKYVIDRRCPATDLEYDPLLNYSAGFFGGILKETGTCKSKRPQHDDDLEVAPCKKLRAASP 206

  Fly    87 TNLMTTIPTNND---------------------LCNTAAAATYDK-------------------- 110
            ..|...:..::|                     .||    ||.||
Frog   207 IRLEIKLQESDDDDILVIDEPPLEADMEKQNPSKCN----ATEDKYLPFCDKIVENTAQITSATE 267

  Fly   111 ------MQSCNKNSSSRITTTN--NNVTTTSNISG--NSSNKRCPQKYTGNTLAVNSNMLAYQQQ 165
                  :|...|:::.|.|.|.  |...|..:.||  |:.:|:.|.:         |...||...
Frog   268 KGGLISLQETTKHTTKRETETKCINMAETFVSQSGNINADDKKLPSE---------SPKAAYSHL 323

  Fly   166 ATAGGKNSTRKSRHNNN----KQNHQQQQQQ-------------QQQQFDHIHKRN-----GTAG 208
            .....||   :.:|..:    :.||:..|.:             :..::..:..:|     |:.|
Frog   324 PIQTEKN---EPKHVTSLECIEDNHKPPQLESIMLVSNQNELCCKLDEYPLMENKNVFWNSGSDG 385

  Fly   209 GTGSECS-PAAPTSNWLQRGYGRQFVHSSCIEDKLLGHHNPGHRNSTSSDATSEDIDSSSELPNK 272
            ..|.:.| ||.           .|....:.:..|.......|....|::|...  :||||:..:.
Frog   386 INGIQASLPAT-----------EQLFAVTELSAKPEQQCQLGSPTLTANDVIV--LDSSSDAVDG 437

  Fly   273 SKGNS-----------CAGSIHASGGSKSRSKRHQKQSGQQTRNPDHNG---------QRTGAAT 317
            |:..:           |....:..  ::..:.|:.||..|.......||         |:...|.
Frog   438 SEAETDLSDSDDPMEECLRIFNEF--AEKEATRNSKQVDQSQLEEFMNGARPDDMVPSQKKRIAH 500

  Fly   318 PCTGQKAKQGN-------AKWRQQQPNPSSNNQQQQMQQQMQQQKRGR------NKKPGKWSNNI 369
            |.|....|..|       ...:||.|:....|.|||..|.....|.|:      .||    ....
Frog   501 PATKIDTKSSNCILVPYRGPTQQQIPHARILNVQQQAVQITAAVKSGQAFVASTQKK----ITGC 561

  Fly   370 IDNPNSNHGGSSQQKTC-----------DSSSSSALSSPTSSATTSATSSP-TNSPTSYPRANGN 422
            |....:|.|    |..|           :.|..:.....:..||::..|.| ..:..:.|..:..
Frog   562 ITPAFNNFG----QMVCVNLVEVQPLLSNRSPFTGFIQGSKLATSTIMSVPQKRTVQTIPVKSCT 622

  Fly   423 RKRIEAALEWRREQELGRQNANFLVPPLRQYEQLEFDDKTVVQQLRRHIIDN---HLLRVYGFPV 484
            ||:..||.|                           ....|..:.|:..:::   ..|:|.|
Frog   623 RKKPFAASE---------------------------SSSKVPHETRQRYVNSFVEEFLKVSG--- 657

  Fly   485 DSVVHEGAIEIFKCMPHMSFAAALAETAQAVTVINYHDGLTNRAEEEVANS---------TDSGN 540
              .|.|            :|..||||.    ..|....|..|.......||         ..||:
Frog   658 --TVQE------------AFDKALAEE----KAIYDRCGSRNMYLSIAVNSLKKLRDQRNVPSGS 704

  Fly   541 SSPQSLDSESG------GEWSGSEC------------------------ESSNSSSSSAG-EAAL 574
            ..|::..|.||      .:.||.:.                        |...|:....| ..::
Frog   705 KQPKTKVSASGLRKQDDKKVSGIDLYNLFKEYVLSDEQLKDNGFPQPNPEKPGSALLQNGITKSI 769

  Fly   575 GLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQRY-YDGVSHGRWTCC 638
            |.::           |.:.|.||...:.: .:.|::...|||.|||||..|: ..|....|::||
Frog   770 GTDV-----------LRRVCCRCGETYSI-TMQGKHTRKEECNYHSGKVLRHRVPGGIETRYSCC 822

  Fly   639 NEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGSGEDEPAVYALDCEMSYTGRGLDVTK 703
             |....||||.:...||..|....::|....|::..   ..:....::::||||.||..||::|:
Frog   823 -EAVVGSPGCQIAKLHVHDGQKENLDGFIKTFIKLP---PSDGNSGIFSVDCEMCYTTCGLELTR 883

  Fly   704 VSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDLCSGAKSLAEVQRDLLQLITADTILIGHG 768
            ||:|..:.|:|||.||:|..:||||||::||:||.:|.:.:.|:.:||..:|.:.:||||||||.
Frog   884 VSVVDPSLQVVYETFVKPDNEIIDYNTRFSGVTEDNLKNVSTSILDVQAVMLNMFSADTILIGHS 948

  Fly   769 LENDLRALRLVHNTLIDTSISFPHCNGFPYRRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACM 833
            |||||.||:|:|:|::||||.|||..|.|::|:||:|...:|:|.||  |...||.|.||:.|||
Frog   949 LENDLLALKLIHDTVVDTSIVFPHRLGLPHKRSLRNLIADYLRRIIQ--DNVGGHDSAEDATACM 1011

  Fly   834 ELMLWRVNRE 843
            |||:|:|..:
Frog  1012 ELMMWKVKED 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
prage	NP_001188528.1	PH-like	<614..650	CDD:302622	18/36 (50%)
		DnaQ	675..>837	CDD:223916	80/161 (50%)
		REX1_like	686..837	CDD:99848	80/150 (53%)
XB5934250	NP_001090720.1	EloA-BP1	625..761	CDD:292495	30/183 (16%)
XB5934250	NP_001090720.1	REX1_like	866..1015	CDD:99848	80/150 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002085
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2254
SonicParanoid	1	1.000	-	-		X1541
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030