DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and Adarb2

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_017171136.1	Gene:	Adarb2 / 94191	MGIID:	2151118	Length:	747	Species:	Mus musculus

Alignment Length:	690	Identity:	270/690 - (39%)
Similarity:	388/690 - (56%)	Gaps:	112/690 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TFPSLPGNPV--SAPSDINMNGYNRKLPQKRGYEMPKYSDPKKKMCKERI--------PQPKNTV 108
            |.|..||:..  |.||      ..||.|.:.|        .....||.::        ..|||.:
Mouse    80 TRPLPPGDWARGSTPS------VKRKRPLEEG--------NGGHFCKLQLIWKKLSWSVTPKNAL 130

  Fly   109 AMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATALRSFIQFKD- 172
            ..|:||:.||.|::.|||||||||:|.::|||:|..:.|.|.:||.|::.||..||:||:||.:
Mouse   131 VQLHELKPGLQYRMVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMRAAEMALKSFVQFPNA 195

  Fly   173 -------GAVLSPLKPAGNLDFTSDE-----------------------H-LENDVSKSAI---- 202
                   |:..||.     .|||||:                       | ::.:...||.
Mouse   196 FQAHLAMGSSTSPC-----TDFTSDQADFPDTLFKEFEPSSKNEDFPGCHPVDTEFLSSAYRRGR 255

  Fly   203 ----TVD--GQKKVPD-----------KGPVMLLYELFNDVNFECINIDGAQNNCR-FKMTVTIN 249
                |:|  || .:||           :.||::|.||.:.:.:.|::....:...: |.|.|.::
Mouse   256 LLYHTLDLMGQ-ALPDRSRLAPGALGERNPVVVLNELRSGLRYVCLSETAEKPRVKSFVMAVCVD 319

  Fly   250 EKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTIGRL 314
            .:.|:|:|.|||.||..||:|||.:|.:|          .:|..|..:|.|..|||..||::.:|
Mouse   320 GRTFEGSGRSKKLAKGQAAQAALQALFDI----------RLPGHIPSRSKSNLLPQDFADSVSQL 374

  Fly   315 VLEKFMEVIKG-QEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHA 378
            |.:||.|:..| ...|:|.|.|||||||:.::..:|:||.:|:||||:||||:|..|.|:||.||
Mouse   375 VTQKFRELTVGLTSVYARHKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVNDCHA 439

  Fly   379 EIVSRRCLLKYLYAQLDLQC--NQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIF 441
            |||:||..|.:||:||:|..  :|....:|||:|..:|  .|:|:..:.||||::|:||||||:.
Mouse   440 EIVARRAFLHFLYSQLELHLSKHQEDPERSIFIRLKEG--GYRLRENILFHLYVSTSPCGDARVN 502

  Fly   442 SPHE--NDTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIAR 504
            ||:|  .|....||..||.||.|||||||||||:||:....:|||||:|.|::|:||||:||||.
Mouse   503 SPYEITTDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGILLGEQLITMSCTDKIAS 567

  Fly   505 WNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNKPRLALVTS 569
            ||::|:||:||...|||||||||::|||.|..|:.|.:..|:| .|..||..|..|:|.|:.|:.
Mouse   568 WNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHRME-GIGQLPASYRQNRPLLSGVSH 631

  Fly   570 AEPRNQAKAPNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKYGFLMANLPGILVRKV 634
            ||.|...|:|:|..||.:|..:||::|:.||:...|..||:.|..|...:    |.|.|.|..::
Mouse   632 AEARQPGKSPHFSANWVVGSADLEIINATTGKRSCGGSSRLCKHVFSAWW----ARLHGRLSTRI 692

  Fly   635 TTD------YGQTKANVKDYQIAKLELFSAFKREDLGSWL 668
            .:.      |.:.|.....||..|.:||.||::..||:|:
Mouse   693 PSHGDTPSMYCEAKQGAHTYQSVKQQLFKAFQKAGLGTWV 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	31/61 (51%)
		DSRM_SF	213..>259	CDD:412133	12/46 (26%)
		ADEAMc	306..677	CDD:214718	173/374 (46%)
Adarb2	XP_017171136.1	DSRM_RED2_rpt1	122..195	CDD:380725	36/72 (50%)
		DSRM_SF	276..349	CDD:381777	24/82 (29%)
		ADEAMc	366..739	CDD:214718	173/374 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I988
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	1	1.000	-	-		FOG0002274
OrthoInspector	1	1.000	-	-		otm43996
orthoMCL	1	0.900	-	-		OOG6_104480
Panther	1	1.100	-	-	O	PTHR10910
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	1	1.000	-	-		X1704
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860