Protein Alignment Adar and Adar

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_006232836.1
• Gene: Adar / 81635
• RGDID: 71099
• Length: 1183
• Species: Rattus norvegicus
• Alignment Length: 807
• Identity: 229/807 - (28%)
• Similarity: 354/807 - (43%)
• Gaps: 211/807 - (26%)

  Fly    56 PSLPGNPVS-----APSDI--NMNGYNRKLPQKRG-YEMPKYSDPKKKMCKERIPQPKNTVAMLN 112
            ||..|...|     |..||  |:|..:....:.|. .|||.:..|....|.   |..|.|...|.
  Rat   399 PSRAGYVASENGPWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCS---PYKKLTECQLK 460

  Fly   113 ELRHGLI-----------YKLESQTGPVHAPLFTISVEVDGQKY-LGQGRSKKVARIEAAATALR 165
            ....||:           :.|..|:||.|.|.|...|.::|::: ..:..|||||:.:||..|:
  Rat   461 NPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAVKAM- 524

  Fly   166 SFIQFKDGAVL---SPLKPAGNLDFTSDEHLENDVSKSAITVDGQKKVPD---------KGPVML 218
                    |:|   :..|.:|..:..|:..:|.|..|.|     :.:.|.         |.||..
  Rat   525 --------AILLREAKAKDSGQPEELSNCPMEEDPEKPA-----ESQPPSSSATSLFSGKSPVTT 576

  Fly   219 LYE----LFNDVNFECINIDGAQNNCRFKMTVTINEKKFDG-TGPSKKTAKNAAAKAALASL--- 275
            |.|    |.|...|..::.:|..::.:|:..|.:..:.|.. :.||||.||..||:.|:.:|
  Rat   577 LLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALQEE 641

  Fly   276 -----------CNI-SYSPMVVPQK----------------------------NVPLPIDDKSSS 300
                       .|. |....|.|.|                            .....:.|:|..
  Rat   642 AANSADDQSGGANTDSLDESVAPNKIRRIGELVRYLNTNPVGGLLEYARSHGFAAEFKLIDQSGP 706

  Fly   301 MELP-------------------------QIHADTIGRLVL---EK-----FMEVI--------- 323
            ...|                         |..||...|:::   ||     |.||.
  Rat   707 PHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIGESEKAEQLGFAEVTPVTGASLRR 771

  Fly   324 ------KGQEAYSR----------------------------------RKVLAGIVM---TENMN 345
                  :..:|:.:                                  ||:||.|:|   .|:|.
  Rat   772 TMLLLSRSPDAHPKTLPLTGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILAAIIMKRDPEDMG 836

  Fly   346 FCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVR 410
            .    |:|:.||.:||.|:.:|:.|..:||.||||:|||..:::||::| ::.|..||..|||..
  Rat   837 V----VVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSEL-MKYNHHTAKNSIFEL 896

  Fly   411 NTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNR-------KARGQLRTKIES 468
            ...|: ..::|..|.|||||:||||||..:|....:|..|:...:|       ..:|:||||:|:
  Rat   897 ARGGE-KLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVEN 960

  Fly   469 GEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLL 533
            |||||||:|||.:.||||:..|:||.||||||||.|||::|:||:||:..::||||.|:.||.|.
  Rat   961 GEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLF 1025

  Fly   534 HPEHMYRAVCGRIEKS----IQGLPPPYHLNKPRLALVTSAEPRNQA-KAPNFGINWTIGD-TEL 592
            ...|:.||:|.|:.:.    ..||..|:.:|.|::..|:..:.:.|: |.....:||.:.| .:|
  Rat  1026 SQGHLTRAICCRVTRDGNAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCLADGYDL 1090

  Fly   593 EVVNSLTGRTIGG---QVSRITKQAFFVKYGFLMANLPGILVRK--VTTDYGQTKANVKDYQIAK 652
            |:::...| |:.|   ::||::|:..|:::    ..|.....|:  :...||:.|...:||.:||
  Rat  1091 EILDGTRG-TVDGPGKELSRVSKKNIFLQF----KKLCSFRARRDLLQLSYGEAKKAARDYDLAK 1150

  Fly   653 LELFSAFKREDLGSWLKKPIEQDEFGL 679
            .....:.:....|:|:.||.|:..|.|
  Rat  1151 NYFKKSLRDMGYGNWISKPQEEKNFYL 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	22/73 (30%)
		DSRM_SF	213..>259	CDD:444671	12/50 (24%)
		ADEAMc	306..677	CDD:214718	148/448 (33%)
Adar	XP_006232836.1	z-alpha	145..211	CDD:280459
		z-alpha	253..317	CDD:295419
		DSRM_DRADA_rpt1	460..530	CDD:380742	23/84 (27%)
		DSRM_SF	571..641	CDD:444671	21/113 (19%)
		DSRM_DRADA_rpt3	679..749	CDD:380744	29/72 (40%)
		ADEAMc	793..1176	CDD:214718	90/248 (36%)