DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adar and Adat1

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001103081.1	Gene:	Adat1 / 690810	RGDID:	1591020	Length:	497	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	123/503 - (24%)
Similarity:	207/503 - (41%)	Gaps:	143/503 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 ADTIGRLVLEKFMEVIKGQEAYSRRK--VLAGIV--MTENMNFCEA---------KVISVSTGTK 359
            ||.|.:|....::::.|..:....|:  :||.:|  .|.....|:.         :|:|:.||||
  Rat     4 ADEIAQLCYAHYIKLPKQGKPEPNREWTLLAAVVKIQTPANQACDTPDKQIQVTKEVVSMGTGTK 68

  Fly   360 CVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAYQSIFVRNTDGQYPYKLKSGV 424
            |:....|..:|.:|||||||:::||...:|:..||.:..  .....|||:..|. :..::|:..:
  Rat    69 CIGQSKMRESGDILNDSHAEVIARRSFQRYILHQLHVAA--VLKEDSIFLPGTQ-RGLWRLRPDL 130

  Fly   425 HFHLYINTAPCGDARIF--------------------SPHENDTGVDKHPNRKA----------- 458
            .|..:.:..|||||.|.                    ||.|....::...|:::
  Rat   131 SFVFFSSHTPCGDASIIPKLEFEEQPCCPVIRNWANNSPGEGSETLEGSRNKRSCEGPDSPVAKK 195

  Fly   459 ------RGQLRTKI------ESGEGTIPVKSSDGI------------------------------ 481
                  .|.|...:      |||... |..||.|:
  Rat   196 KRLGTPAGSLSDCVAHHGAQESGPAK-PDASSSGLTKEELDAVNGTASGSFKVVDIYRTGAKCVP 259

  Fly   482 -QTWD-----------GVL-----QGQRLLTMSCSDKIARWNIVGIQGSLLSSIIE-PVYLHSIV 528
             :|.|           |:|     :|.|..:||||||:||||::|.||:||...:| |:||.::|
  Rat   260 GETGDLRKPGAAYHQVGLLRVKPGRGDRTCSMSCSDKMARWNVLGCQGALLMHFLEKPIYLSAVV 324

  Fly   529 LGSLLH-PEHMYRAVCGRIEKSIQGLPPPYHLNKPRLALVT-------SAEPRNQAKAP------ 579
            :|...: .|.|.||:.||.::::. ||..:.:.:.::...:       .|..|.:..:|
  Rat   325 IGQCPYSQEAMRRALTGRCQETLV-LPRGFEVQELKIQQSSLLFEQSRCAVHRKRGDSPGRLVPC 388

  Fly   580 NFGINWT-IGDTELEVV-----NSLTGRTIGG--QVSRITKQAFFVKYGFLMANL------PGIL 630
            ...|:|: :....|:|.     ...|.:.||.  ..|||:|...|..:..|::.:      ..:.
  Rat   389 GAAISWSAVPQQPLDVTANGFPQGTTKKEIGSPRARSRISKVELFRSFQKLLSCIAEDERPDSVR 453

  Fly   631 VRKVTTDYGQTKANVKDYQIAKLELFSAFKR-EDLGSWLKKPIEQDEF 677
            |:|:.| |.:.|.....||    |.:||.:| :...||::.|....:|
  Rat   454 VQKLDT-YQEYKEAASAYQ----EAWSALRRVQPFSSWIRNPPNYHQF 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694
		DSRM_SF	213..>259	CDD:412133
		ADEAMc	306..677	CDD:214718	122/501 (24%)
Adat1	NP_001103081.1	A_deamin	62..490	CDD:396626	109/437 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820