DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and adar

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_571671.2	Gene:	adar / 58119	ZFINID:	ZDB-GENE-000616-5	Length:	1381	Species:	Danio rerio

Alignment Length:	817	Identity:	227/817 - (27%)
Similarity:	354/817 - (43%)	Gaps:	217/817 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LPG-NPVSAPSDINMNGYNRKLPQKRGY--EMPKYSDPKKKMCKERIPQ---------------- 103
            :|| .|||..||::.:.:....|.:..|  |.|.....:.:...:.||:
Zfish   542 IPGLEPVSKASDLSSSTHRNFQPNQFPYYQETPSNGGEQSQWASDDIPEFLNTIRSEVAVSLAAP 606

  Fly   104 -------------------PKNTVAMLNELRHGLIYKLE----SQTGPVHAPLFTISVEVDGQKY 145
                               .||.|:.|.|....|.|..|    .|:||.|.|.|.:.|.:||:::
Zfish   607 PPPTQSMESNRLQKLKEARSKNPVSGLMEFAQHLGYTCEFLLLEQSGPSHDPRFRMQVMLDGRRF 671

  Fly   146 -LGQGRSKKVARIEAAATALRSFIQFKDGA----VLSP-LKPAGNLDFTSDEHLENDVSKSAITV 204
             ..:|.:||||:.:|||..|:...:..||.    ...| ::.||:....:|:....|....|::
Zfish   672 PAAEGSNKKVAKKDAAAITLKILWKELDGGGGEEEEEPNIEGAGSTTDMADDMGGTDTPPQALS- 735

  Fly   205 DGQKKVP-DKGPVMLLYE----LFNDVNFECINIDGAQNNCRFKMTVTINEKKF-DGTGPSKKTA 263
               :.:| .|.||.:|.|    ..:.:.|.....:|..::.||...|.:.|:.| :.:.||||.|
Zfish   736 ---RSLPGGKNPVSVLMEHSQRSGHPIQFIKTGQEGPSHDPRFMFRVKVGERLFQEASAPSKKAA 797

  Fly   264 KNAAAKAAL---------------ASLCNISYS---PMVVPQKNVPLPIDDKSSSMELPQIHADT 310
            :..||:.|:               :|.|.:..|   ||.....::| |:    ::.||...|...
Zfish   798 RQLAAEEAVKELMGDGLLHLNKPPSSFCPMGDSESQPMFPACPSLP-PL----TAAELQAAHEAG 857

  Fly   311 IGRLVLEKFMEVIKGQEAYSR-------------------------------------------- 331
            :|.|:.......:.|...|:|
Zfish   858 VGDLINHLNNNAVSGLLEYARARGFAAEIRLVGQSGPSHEPKFTYQAKLGGRWFPAVCASNKKQG 922

  Fly   332 -------------------------------------------------------------RKVL 335
                                                                         ||:|
Zfish   923 KQEAADAALRVLIGEAEKAARTGELMPELPVSGSTIHDQIAMLSHQRFNALTARIQHSLLGRKIL 987

  Fly   336 AGIVM---TENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQ 397
            |.|||   |:::    .||:|:.||.:||.||.:|:.|..:||.||||:|||..:::||::| ::
Zfish   988 ATIVMRNGTDSL----GKVVSLGTGNRCVKGEELSLRGDTVNDCHAEIISRRGFIRFLYSEL-MK 1047

  Fly   398 CNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIF------SPHENDTG-VDKHPN 455
            ..::...::||....||:  .|:||.:.|||||:||||||..:|      :...|.:| :....|
Zfish  1048 HWESPGDETIFELAGDGK--LKIKSDITFHLYISTAPCGDGALFDKSCSEAAELNGSGHMPLFEN 1110

  Fly   456 RKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIE 520
            .| :|:||||:|:|||||||:|||.:.||||:..|:||.||||||||.|||::|:||:||:..|.
Zfish  1111 IK-QGKLRTKVENGEGTIPVESSDIVPTWDGIQHGERLRTMSCSDKILRWNVLGLQGALLTHFIH 1174

  Fly   521 PVYLHSIVLGSLLHPEHMYRAVCGRIEKS----IQGLPPPYHLNKPRLALVTSAE-PRNQAKAPN 580
            |:|||||.||.|....|:.||||.|:.:.    ...||..:.||.|.:..|:..: .|:.:|...
Zfish  1175 PIYLHSITLGYLYSHGHLTRAVCCRLSRDGDTFKSSLPANFTLNHPEVGRVSVYDSTRHTSKTKE 1239

  Fly   581 FGINWTIGDT-ELEVVNSLTGRTIGG--QVSRITKQAFFVKYGFL--MANLPGILVRKVTTDYGQ 640
            ..:||:..|. .:||::...|:....  :|||::|...|..:..|  .|....:|..:   .|..
Zfish  1240 SSVNWSQPDQYSVEVLDGTKGKLDSPKMEVSRVSKSNLFRLFHALCQRAGRADLLALQ---SYAH 1301

  Fly   641 TKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEF 677
            .|.....:|.||...|.|..:...|:|:.||:|:..|
Zfish  1302 AKMAATSFQEAKRLFFLALSQHGYGAWIGKPLEEKSF 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	26/66 (39%)
		DSRM_SF	213..>259	CDD:412133	12/50 (24%)
		ADEAMc	306..677	CDD:214718	149/495 (30%)
adar	NP_571671.2	Zalpha	252..319	CDD:128823
		Zalpha	409..476	CDD:128823
		DSRM	629..>678	CDD:214634	16/48 (33%)
		DSRM	744..809	CDD:214634	19/64 (30%)
		DSRM	868..934	CDD:238007	3/65 (5%)
		ADEAMc	957..1338	CDD:214718	143/391 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2305
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850