Protein Alignment Adar and Adar

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001344887.1
• Gene: Adar / 56417
• MGIID: 1889575
• Length: 1217
• Species: Mus musculus
• Alignment Length: 884
• Identity: 232/884 - (26%)
• Similarity: 363/884 - (41%)
• Gaps: 270/884 - (30%)

  Fly    13 YKSCHHAMRVARSSFGYQRQQFYAASSYAGKRSRFFVKRRFTFPSLPGNPVSAPSDINMNGYNRK 77
            :.:||.....|.||        .|||..........:|......:.||     |..:..:.|:..
Mouse   381 FPACHPPPAGASSS--------VAASKRVENGQEPAIKHESRHEARPG-----PMRLRPHAYHNG 432

  Fly    78 LPQKRGY-------------------------------EMPKYSDPKKKMCKERIPQPKNTVAML 111
             |.:.||                               |||.:..|....|.   |..|.|...|
Mouse   433 -PSRAGYVASENGQWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCS---PYKKLTECQL 493

  Fly   112 NELRHGLI-----------YKLESQTGPVHAPLFTISVEVDGQKY-LGQGRSKKVARIEAAATAL 164
            .....||:           :.|..|:||.|.|.|...|.::|::: ..:..|||||:.:||..|:
Mouse   494 KNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAVKAM 558

  Fly   165 RSFIQFKDGAVL---SPLKPAGNLDFTSDEHLENDVSKSAITVDGQKKVPD---------KGPVM 217
                     |:|   :..|.:|..:..|...:|.|..|.|     :.:.|.         |.||.
Mouse   559 ---------AILLREAKAKDSGQPEDLSHCPMEEDSEKPA-----EAQAPSSSATSLFSGKSPVT 609

  Fly   218 LLYE----LFNDVNFECINIDGAQNNCRFKMTVTINEKKFDG-TGPSKKTAKNAAAKAALASLCN 277
            .|.|    |.|...|..::.:|..::.:|:..|.:..:.|.. :.||||.||..||:.|:.:|
Mouse   610 TLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPPVSAPSKKVAKQMAAEEAMKAL-- 672

  Fly   278 ISYSPMVVPQKNVPLPIDDKSSS---------------------------------MELPQIH-- 307
                     |:......||:|..                                 :|..:.|
Mouse   673 ---------QEEAASSADDQSGGANTDSLDESMAPNKIRRIGELVRYLNTNPVGGLLEYARSHGF 728

  Fly   308 --------------------------------------------ADTIGRLVL---EK-----FM 320
                                                        ||...|:::   ||     |.
Mouse   729 AAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIGESEKAEQLGFA 793

  Fly   321 EVI---------------KGQEAYSR----------------------------------RKVLA 336
            ||.               :..:|:.:                                  ||:||
Mouse   794 EVTPVTGASLRRTMLLLSRSPDAHPKTLPLSGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILA 858

  Fly   337 GIVM---TENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQC 398
            .|:|   .|:|..    |:|:.||.:||.|:.:|:.|..:||.||||:|||..:::||::| ::.
Mouse   859 AIIMKRDPEDMGV----VVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSEL-MKY 918

  Fly   399 NQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNR------- 456
            |..||..|||.....|: ..::|..|.|||||:||||||..:|....:|..|:...:|
Mouse   919 NHHTAKNSIFELARGGE-KLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESRHYPVFEN 982

  Fly   457 KARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIEP 521
            ..:|:||||:|:|||||||:|||.:.||||:..|:||.||||||||.|||::|:||:||:..::|
Mouse   983 PKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQP 1047

  Fly   522 VYLHSIVLGSLLHPEHMYRAVCGRIEKS----IQGLPPPYHLNKPRLALVTSAEPRNQA-KAPNF 581
            |||.|:.||.|....|:.||:|.|:.:.    ..||..|:.:|.|::..|:..:.:.|: |....
Mouse  1048 VYLKSVTLGYLFSQGHLTRAICCRVTRDGKAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKET 1112

  Fly   582 GINWTIGD-TELEVVNSLTGRTIGG---QVSRITKQAFFVKYGFLMANLPGILVRK--VTTDYGQ 640
            .:||.:.| .:||:::...| |:.|   ::||::|:..|:::    ..|.....|:  :...||:
Mouse  1113 SVNWCMADGYDLEILDGTRG-TVDGPGKELSRVSKKNIFLQF----KKLCSFRARRDLLQLSYGE 1172

  Fly   641 TKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGL 679
            .|...:||.:||.....:.:....|:|:.||.|:..|.|
Mouse  1173 AKKAARDYDLAKNYFKKSLRDMGYGNWISKPQEEKNFYL 1211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	22/73 (30%)
		DSRM_SF	213..>259	CDD:444671	12/50 (24%)
		ADEAMc	306..677	CDD:214718	149/494 (30%)
Adar	NP_001344887.1	z-alpha	176..242	CDD:280459
		z-alpha	287..351	CDD:295419
		DSRM_DRADA_rpt1	494..564	CDD:380742	21/73 (29%)
		DSRM_SF	605..675	CDD:444671	18/103 (17%)
		DSRM_DRADA_rpt3	713..783	CDD:380744	27/69 (39%)
		ADEAMc	827..1210	CDD:214718	88/232 (38%)