DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and Adad1

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006232340.1	Gene:	Adad1 / 294979	RGDID:	1359309	Length:	636	Species:	Rattus norvegicus

Alignment Length:	612	Identity:	159/612 - (25%)
Similarity:	259/612 - (42%)	Gaps:	147/612 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 KLESQTGPVHAPLFTISVEVDGQKYLGQGRS---------KKVARIEAAATALRSFI-QFKDGAV 175
            |:...||....||            |.:|.|         ||:.         :.|| :::.|.:
  Rat    94 KVTQVTGNFPEPL------------LSKGLSSISNPVLPPKKIP---------KEFIMKYRRGEI 137

  Fly   176 LSPLKPAGNL-DFTSDEHLENDVSKSAITVDGQKKVPDKGPVMLLYELFNDVNFECINIDGAQNN 239
                .|...| .|...:.::.|:.::..|          |.||..|..|      |..:||.|
  Rat   138 ----NPVSALHQFAQMQRVQLDLKETVTT----------GNVMGPYFAF------CAVVDGIQ-- 180

  Fly   240 CRFKMTVTINEKKFDGTGPSKKTAKNAAAKAALASLCNIS---------YSPMVVPQKNVPLPID 295
              :|          .|.|.:||.:::.|||.||..|..:.         ..|..:|.:.:..|..
  Rat   181 --YK----------TGLGQNKKESRSNAAKLALDELLQLDEPEPRALEPAGPPPIPAEPIVTPEA 233

  Fly   296 DKSSSMELP--QIHADTIGRLVLEKFMEVIKGQEAYSR-RKVLAGIVMTENMNFCEAKVISVSTG 357
            ...|.::..  |:....|.:||.|.|.::|.....|.: ...||..::....:.   :|:::.||
  Rat   234 AYISKVQYEGRQVQYAKISQLVKETFSQLISSHSQYLKCSSSLAAFIIERGGHH---EVVAIGTG 295

  Fly   358 ----TKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDL--QCNQATAYQSIFVRNTDGQY 416
                ::|:     ..||.||:|:||.:.:||.||:|.|.||.|  ..|.|...:|||........
  Rat   296 EYNYSQCI-----KPNGRVLHDTHAVVTARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPASNL 355

  Fly   417 PYKLKSGVHFHLYINTAPCGDARI-----FSPHENDTGVDKHPNRKARGQLRTKIESGEGTIPVK 476
             ..||..::.:||:|..|.|.|:|     .:||....       .:|..:|...: :.||.|.:.
  Rat   356 -LTLKQNINLYLYMNQLPKGSAQIKSQLRLNPHSISA-------FEANEELSLHV-AVEGKIYLT 411

  Fly   477 ---SSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVL--GSLLHPE 536
               |:||:         .|:.:||.|||:.||.::|:||:|||..|:|||:.||::  |:.....
  Rat   412 VYCSADGV---------NRVNSMSSSDKLTRWEVLGVQGALLSHFIQPVYISSILVGDGNCNDTR 467

  Fly   537 HMYRAVCGRIEKSIQG-LPPPYHLNKPRLALVTSAEP-RNQAKAPNFGINWTIGDTELEVVNSLT 599
            .:..|:..|::.::.. ||..|.:|:|.::||.:|.| :......:..:||..||..||:|:.|:
  Rat   468 GLEIAINQRVDDALTSKLPMFYLVNRPHISLVPTAYPLQINLDHKSLSLNWAQGDNSLEIVDGLS 532

  Fly   600 GRTIG--------GQVSRITKQAFFVKYGFLMANLPGILVRKVTTD-------YGQTKANVKDYQ 649
            |:...        ...||:.|.|...::        .:|.::..||       |...|.....||
  Rat   533 GKITESSPFKSGLSMASRLCKAAMLSRF--------NLLAKEAKTDDLLEARTYHAAKCLSGPYQ 589

  Fly   650 IAKLELFSAFKREDLGSWL-KKP-IEQ 674
            .||..|.:..::...|||: |.| |||
  Rat   590 EAKALLKAYLQQHGYGSWIVKSPCIEQ 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	10/54 (19%)
		DSRM_SF	213..>259	CDD:412133	12/45 (27%)
		ADEAMc	306..677	CDD:214718	116/405 (29%)
Adad1	XP_006232340.1	DSRM	139..204	CDD:214634	24/94 (26%)
Adad1	XP_006232340.1	A_deamin	291..611	CDD:280326	101/350 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820