DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and Adarb1

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_006256337.1	Gene:	Adarb1 / 25367	RGDID:	2033	Length:	775	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	310/705 - (43%)
Similarity:	417/705 - (59%)	Gaps:	89/705 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VKRRFTFPSLPGNPVSAPSDIN----MNGYNRKLPQKRGYEMPKYSDPKKKMCKERIPQ----PK 105
            ||......::|....|.|....    .||......:||..|.......|.::.|.|...    ||
  Rat    80 VKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPK 144

  Fly   106 NTVAMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATALRSFIQF 170
            |.:..|||::.||.|.|.|||||||||||.:||||:||.:.|.|.:||.|::.||..|||||:||
  Rat   145 NALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQF 209

  Fly   171 KD--------GAVLSPLKPAGNLDFTSDE-------------------------------HLEND 196
            .:        |..||.     |.|||||:                               ....|
  Rat   210 PNASEAHLAMGRTLSV-----NTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGD 269

  Fly   197 VSKSAITVDGQKKVP------------DKGPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTIN 249
            ||.||..|......|            .|.|||:|.||...:.::.::..|..:...|.|:|.::
  Rat   270 VSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVD 334

  Fly   250 EKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTIGRL 314
            .:.|:|:|.:||.||..||::|||::.|:....  .|.:.   |:..:...:.|||:.||.:.||
  Rat   335 GQFFEGSGRNKKLAKARAAQSALATVFNLHLDQ--TPSRQ---PVLSEGLQLHLPQVLADAVSRL 394

  Fly   315 VLEKFMEVIKG-QEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHA 378
            ||.||.::... ...::|||||:|:|||...:..:||||||||||||::||:||..|..|||.||
  Rat   395 VLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHA 459

  Fly   379 EIVSRRCLLKYLYAQLDLQC-NQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFS 442
            ||:|||.||::|||||:|.. |:....:|||.::..|  .::||..|.|||||:|:|||||||||
  Rat   460 EIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERG--GFRLKDTVQFHLYISTSPCGDARIFS 522

  Fly   443 PHEN------------DTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLT 495
            |||.            ....|:|||||||||||||||||||||||:|:..||||||||||:||||
  Rat   523 PHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLT 587

  Fly   496 MSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLN 560
            |||||||||||:|||||:|||..:||:|..||:||||.|.:|:.||:..|| .:|:.|||.|.||
  Rat   588 MSCSDKIARWNVVGIQGALLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRI-SNIEDLPPLYTLN 651

  Fly   561 KPRLALVTSAEPRNQAKAPNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKYGFLMAN 625
            ||.|:.:::||.|...|||||.:|||:|||.:||:|:.||:...|:.||:.|.|.:.::..:...
  Rat   652 KPLLSGISNAEARQPGKAPNFSVNWTVGDTAIEVINATTGKDELGRPSRLCKHALYCRWMRVHGK 716

  Fly   626 LPGILVR-KVT--TDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEF 677
            :|..|:| |:|  |.|.::|...|:||.||..||:||.:..||:|::||.|||:|
  Rat   717 VPPHLLRTKITKPTTYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQF 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	36/61 (59%)
		DSRM_SF	213..>259	CDD:412133	14/45 (31%)
		ADEAMc	306..677	CDD:214718	210/387 (54%)
Adarb1	XP_006256337.1	DSRM	143..206	CDD:238007	37/62 (60%)
		DSRM	299..357	CDD:238007	19/57 (33%)
		ADEAMc	386..772	CDD:214718	211/389 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I949
eggNOG	1	0.900	-	-		E1_KOG2777
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8280
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1232
OMA	1	1.010	-	-		QHG48426
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	1	1.000	-	-		FOG0002274
OrthoInspector	1	1.000	-	-		otm46085
orthoMCL	1	0.900	-	-		OOG6_104480
Panther	1	1.100	-	-	LDO	PTHR10910
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840