Protein Alignment Adar and Adad1

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_033376.2
• Gene: Adad1 / 21744
• MGIID: 103258
• Length: 619
• Species: Mus musculus
• Alignment Length: 649
• Identity: 169/649 - (26%)
• Similarity: 271/649 - (41%)
• Gaps: 147/649 - (22%)

  Fly    86 MPKYSDPKKKMCKERIP-QPK-NTVAM----------LNELRHGLIYKLESQTGPVHAPLFTISV 138
            :|.::    :|.|:.:| ||. .||.:          |:.:..    |:...||....||
Mouse    55 VPSFA----QMLKKNLPVQPSAQTVTLPTGYSSESCSLSNMAS----KVTQVTGNFPEPL----- 106

  Fly   139 EVDGQKYLGQGRSKKVARIEAAATALRSFI-QFKDGAVLSPLKPAGNL-DFTSDEHLENDVSKSA 201
                   |.:|.|.....:.......:.|| ::|.|.:    .|...| .|...:.::.|:.::.
Mouse   107 -------LSKGLSSISNPVLPPKKLPKEFIMKYKRGEI----NPVSALHQFAQMQRVQLDLKETV 160

  Fly   202 ITVDGQKKVPDKGPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNA 266
            .|          |.||..|..|      |..:||.|    :|          .|.|.:||.:::.
Mouse   161 TT----------GNVMGPYFAF------CAVVDGIQ----YK----------TGLGQNKKESRSN 195

  Fly   267 AAKAALASLCNISY-SPMVV-PQKNVPLPIDD---------KSSSMELPQIHADTIGRLVLEKFM 320
            |||.||..|..:.. .|.|: |....|:|.:.         .....|..|:....|.:||.|.|.
Mouse   196 AAKLALDELLQLDEPEPRVLEPAGPPPIPAEPVVTPEAAYVSKVQYEGRQVQYAKISQLVKETFG 260

  Fly   321 EVIKGQEAYSRRKVLAGIVMTENMNFCEAKVISVSTG----TKCVSGEHMSVNGAVLNDSHAEIV 381
            ::|.....|.:........:.|.....|  |:::.||    ::|:     ..||.||:|:||.:.
Mouse   261 QLISNHSQYLKCSSSLAAFIIERAGHHE--VVAIGTGEYNYSQCI-----KPNGRVLHDTHAVVT 318

  Fly   382 SRRCLLKYLYAQLDL--QCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARI---- 440
            :||.||:|.|.||.|  ..|.|...:|||........ ..||..::.:||:|..|.|.|:|
Mouse   319 ARRSLLRYFYRQLLLFYSKNPAMMEKSIFCTEPASNL-LTLKQNINLYLYMNQLPKGSAQIKSQL 382

  Fly   441 -FSPHENDTGVDKHPNRKARGQLRTKIESGEGTIPVK---SSDGIQTWDGVLQGQRLLTMSCSDK 501
             .:||....       .:|..:|...: :.||.|.:.   |:||:         .|:.:||.|||
Mouse   383 RLNPHSISA-------FEANEELSLHV-AVEGKIYLTVYCSADGV---------NRVNSMSSSDK 430

  Fly   502 IARWNIVGIQGSLLSSIIEPVYLHSIVL--GSLLHPEHMYRAVCGRIEKSIQG-LPPPYHLNKPR 563
            :.||.::|:||:|||..|:|||:.||::  |:......:..|:..|::.::.. ||..|.:|:|.
Mouse   431 LTRWEVLGVQGALLSHFIQPVYISSILVGDGNCNDTRGLEIAINQRVDDALTSKLPMFYLVNRPH 495

  Fly   564 LALVTSAEP-RNQAKAPNFGINWTIGDTELEVVNSLTGRTIG--------GQVSRITKQAFFVKY 619
            ::||.:|.| :......:..:||..||..||:|:.|.|:...        ...||:.|.|...::
Mouse   496 ISLVPTAYPLQINLDHKSLSLNWAQGDNSLEIVDGLNGKITESSPFKSGLSMASRLCKAAMLSRF 560

  Fly   620 GFLMANLPGILVRKVTTD-------YGQTKANVKDYQIAKLELFSAFKREDLGSWL-KKP-IEQ 674
                    .:|.::..||       |...|.....||.||..|.:..::...|||: |.| |||
Mouse   561 --------NLLAKEAKTDDLLEARTYHAAKCMSGPYQEAKALLKAYLQQHGYGSWIVKSPCIEQ 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	11/72 (15%)
		DSRM_SF	213..>259	CDD:444671	12/45 (27%)
		ADEAMc	306..677	CDD:214718	116/404 (29%)
Adad1	NP_033376.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50
		DSRM_ADAD1	137..205	CDD:380734	24/101 (24%)
		ADEAMc	246..618	CDD:214718	116/404 (29%)