Protein Alignment Adar and adr-1

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_492153.2
• Gene: adr-1 / 172542
• WormBaseID: WBGene00000079
• Length: 964
• Species: Caenorhabditis elegans
• Alignment Length: 712
• Identity: 166/712 - (23%)
• Similarity: 271/712 - (38%)
• Gaps: 176/712 - (24%)

  Fly    56 PSLPGNPVSAPSDINMNGYNRKLPQKRGY---------------EMPKYS--DPKKKMCKERIPQ 103
            |.:|...|. ..:::.||.|....:|.|:               :..:|:  .|.:.:.|:.:.:
 Worm   339 PEIPEVEVK-KEEVDTNGENVANEKKSGWRKNETMHNVTLKFVEQNKQYTKMGPSRGVLKDMVIR 402

  Fly   104 PK------------NTVA---MLNELRHG--LIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRS 151
            ..            .|||   ..|.|.|.  ::..|.:....::..| ||..|....:.||.||:
 Worm   403 EALRDLFNVSHADITTVARRHASNRLGHDTTILQCLNTICSILNCTL-TIECEPAEDRPLGIGRA 466

  Fly   152 KKVA------------RIEAAATALRSFIQFKDGAVLSPLKPAGNLDFTSDEHLENDVSKSAITV 204
            ..:|            :.|..:::|.|....||......||....:|           ..|.:..
 Worm   467 YFMAKCTIIDHNENDLKFEVKSSSLASKAMAKDWVAQETLKNYFAID-----------PSSCVKT 520

  Fly   205 DGQKKVPDKGPVMLLYELFNDVNFECINID----------GAQNNCRFKMTVTINE-KKFDGTGP 258
            |.   |..:||..||:.:.|....:...|.          ..|....|.....|:| .::.|.|.
 Worm   521 DA---VSSQGPCALLHAMLNKQTKQKCKIAYEFKDNVPPVAGQATTTFYCECVIDETDRYIGVGR 582

  Fly   259 SKKTAKNAAAKAALASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTIGRLVLE------ 317
            |||.||:.||..||..|..|.|.    |..|.||.:    :|..:.:.....:.|.:.|
 Worm   583 SKKLAKSEAAMQALKKLFKIDYD----PAGNYPLAL----TSRAMTESKVSPLCRHIAEFCKREY 639

  Fly   318 ----KFMEV-----------IKGQEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMS 367
                ::.::           :..||   .::|||   |..::.:    ::...|    :||
 Worm   640 HQMTEYYQIPPSNLFAAFLLVNAQE---EKRVLA---MGSSIQY----IVEPDT----LSG---- 686

  Fly   368 VNGAVLNDSHAEIVSRRCLLKYLYAQL---DLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLY 429
            .||..|....|.|::||.:||....:|   |.:|       |||.:..:|:  ..||..:...||
 Worm   687 ANGTSLLHLDAIILARRAMLKAFIHELSTVDSEC-------SIFEKKEEGK--AALKPNLRLVLY 742

  Fly   430 IN-TAPCGDARIFSPHENDTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRL 493
            .| :.||..|           ||....:|......|.:.    .:|    |.:.|::.:.:.:.|
 Worm   743 SNYSPPCIHA-----------VDDAATKKLSYVTPTNLT----CVP----DDVLTYEQIKETKSL 788

  Fly   494 LTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGS--LLHPEHMYRAVCGRIEKSIQGLPPP 556
            .....:||:.:||.:||||:|||:::.|:::.:|..||  .:..|.:..|:.||       |.|
 Worm   789 RVHCTADKLFKWNTLGIQGALLSNVLHPIFIDNIFFGSEAPVSDESLSYALQGR-------LGP- 845

  Fly   557 YHLNKPRLALVTSAEPRNQAKAPNFGIN--WTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKY 619
               |:....::..:.|.....  :.||:  |..|...:|.::..||||..|..||:.|...|..|
 Worm   846 ---NENEREIIVESMPVQMRM--HMGISHLWHRGVDSVETLDYNTGRTSKGSPSRVCKAEIFEAY 905

  Fly   620 GFLMANLPGILVRKVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIE-QDEFGLA 680
                ..|.|  |.:...:|.:.|....:||..|...:...:...||.|..||.| .|.|.||
 Worm   906 ----RKLNG--VDQAVVNYAKAKEMASEYQYEKKVFYEKLEAAGLGKWQTKPAELVDSFTLA 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	18/90 (20%)
		DSRM_SF	213..>259	CDD:444671	12/56 (21%)
		ADEAMc	306..677	CDD:214718	96/400 (24%)
adr-1	NP_492153.2	DSRM	180..238	CDD:214634
		DSRM	528..600	CDD:214634	20/71 (28%)
		ADEAMc	630..958	CDD:214718	95/392 (24%)