Protein Alignment Adar and ADAD1

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_640336.1
• Gene: ADAD1 / 132612
• HGNCID: 30713
• Length: 576
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 165/639 - (25%)
• Similarity: 272/639 - (42%)
• Gaps: 126/639 - (19%)

  Fly    85 EMPKYSDPKKKMCKERIP-QPK----NTVAMLNELRHGL---IYKLESQTGPVHAPLFTISVEVD 141
            ::|.::    :|.|:.:| ||.    .|....:...:||   ..|:...||....||.:.::...
Human    12 QVPSFA----QMLKKNLPVQPATKTITTPTGWSSESYGLSKMASKVTQVTGNFPEPLLSKNLSSI 72

  Fly   142 GQKYLGQGRSKKVARIEAAATALRSFI-QFKDGAVLSPLKPAGNL-DFTSDEHLENDVSKSAITV 204
            ....|   ..||:.         :.|| ::|.|.:    .|...| .|...:.::.|:.::..|
Human    73 SNPVL---PPKKIP---------KEFIMKYKRGEI----NPVSALHQFAQMQRVQLDLKETVTT- 120

  Fly   205 DGQKKVPDKGPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNAAAK 269
                     |.||..|..|      |..:||.|    :|          .|.|.:||.:::.|||
Human   121 ---------GNVMGPYFAF------CAVVDGIQ----YK----------TGLGQNKKESRSNAAK 156

  Fly   270 AALASLCNISYSPMVVPQKNVPLPIDDK----SSSMELPQIHAD-------TIGRLVLEKFMEVI 323
            .||..|..:......:.:.:.|.|...:    |....:.::|.:       .|.::|.|:|.::|
Human   157 LALDELLQLDEPEPRILETSGPPPFPAEPVVLSELAYVSKVHYEGRHIQYAKISQIVKERFNQLI 221

  Fly   324 KGQEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLK 388
            ..:..|.:........:.|...  :.:|:::.||....| :.:..:|.||:|:||.:.:||.||:
Human   222 SNRSEYLKYSSSLAAFIIERAG--QHEVVAIGTGEYNYS-QDIKPDGRVLHDTHAVVTARRSLLR 283

  Fly   389 YLYAQLDL--QCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVD 451
            |.|.||.|  ..|.|...:|||........ ..||..::..||:|..|.|.|:|
Human   284 YFYRQLLLFYSKNPAMMEKSIFCTEPTSNL-LTLKQNINICLYMNQLPKGSAQI----------- 336

  Fly   452 KHPNRKARGQLR------TKIESGEGT---IPVKSSDGIQTW---DGVLQGQRLLTMSCSDKIAR 504
                   :.|||      :..|:.|..   :.|:....:..:   |||   .|:.:||.|||:.|
Human   337 -------KSQLRLNPHSISAFEANEELCLHVAVEGKIYLTVYCPKDGV---NRISSMSSSDKLTR 391

  Fly   505 WNIVGIQGSLLSSIIEPVYLHSIVL--GSLLHPEHMYRAVCGRIEKSIQG-LPPPYHLNKPRLAL 566
            |.::|:||:|||..|:|||:.||::  |:......:..|:..|::.::.. ||..|.:|:|.::|
Human   392 WEVLGVQGALLSHFIQPVYISSILIGDGNCSDTRGLEIAIKQRVDDALTSKLPMFYLVNRPHISL 456

  Fly   567 VTSAEPRNQAKAPNF-GINWTIGDTELEVVNSLTGRTIG--------GQVSRITKQAFFVKYGFL 622
            |.||.|........| .:||..||..||:|:.|:|:...        ...||:.|.|...::..|
Human   457 VPSAYPLQMNLEYKFLSLNWAQGDVSLEIVDGLSGKITESSPFKSGMSMASRLCKAAMLSRFNLL 521

  Fly   623 MANLPGILVRKVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWL-KKP-IEQ 674
            .......|:...|  |...|.....||.||.:|.|..::...|||: |.| |||
Human   522 AKEAKKELLEAGT--YHAAKCMSASYQEAKCKLKSYLQQHGYGSWIVKSPCIEQ 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	11/68 (16%)
		DSRM_SF	213..>259	CDD:444671	12/45 (27%)
		ADEAMc	306..677	CDD:214718	116/404 (29%)
ADAD1	NP_640336.1	DSRM_ADAD1	95..163	CDD:380734	24/101 (24%)
		ADEAMc	204..575	CDD:214718	115/397 (29%)