DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and Adarb2

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_579836.1	Gene:	Adarb2 / 117088	RGDID:	621519	Length:	746	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	275/703 - (39%)
Similarity:	398/703 - (56%)	Gaps:	97/703 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VKRRFTFPSLPGNPVSAPSDINMNGYNRKLPQKRGYEMPKYSDPKKKMCKERI--------PQPK 105
            ||......:|...|: .|.|....|....:.:||    |.........||.::        ..||
  Rat    69 VKENRNVSNLGTRPL-PPGDWARGGSTPSVKRKR----PLEEGNGGHFCKLQLIWKKLSWSMTPK 128

  Fly   106 NTVAMLNELRHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATALRSFIQF 170
            |.:..|:||:.||.|::.|||||||||:|.::|||:|..:.|.|.:||.|::.||..||:||:||
  Rat   129 NALVQLHELKPGLQYRMVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMRAAEMALKSFVQF 193

  Fly   171 KD--------GAVLSPLKPAGNLDFTSDE------------------------HLENDVSKSAI- 202
            .:        |:..||.     .|||||:                        .::.:...||.
  Rat   194 PNAFQAHLAMGSSTSPC-----TDFTSDQADFPDTLFKEFEPSSRNEDFPGCCPVDTEFLSSAYR 253

  Fly   203 -------TVD--GQKKVPD-----------KGPVMLLYELFNDVNFECINIDGAQNNCR-FKMTV 246
                   |:|  || .:||           :.||::|.||.:.:.:.|::....:...: |.|.|
  Rat   254 RGRLLYHTLDLMGQ-ALPDRSRLAPGALGERNPVVVLNELRSGLRYVCLSETAEKPRVKSFVMAV 317

  Fly   247 TINEKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQKNVPLPIDDKSSSMELPQIHADTI 311
            .::.:.|:|:|.|||.||..||:|||.:|.:|          .:|..|..:|.|..|||..||::
  Rat   318 CVDGRTFEGSGRSKKLAKGQAAQAALQALFDI----------RLPGHIPSRSKSNLLPQDFADSV 372

  Fly   312 GRLVLEKFMEVIKG-QEAYSRRKVLAGIVMTENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLND 375
            .:||.:||.|:..| ...|:|.|.|||||||:.::..:|:||.:|:||||:||||:|..|.|:||
  Rat   373 SQLVTQKFRELTVGLTSVYARHKTLAGIVMTKGLDTKQAQVIVLSSGTKCISGEHISDQGLVVND 437

  Fly   376 SHAEIVSRRCLLKYLYAQLDLQC--NQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDA 438
            .|||||:||..|.:||.||:|..  :|....:|||:|..:|  .|:|:..:.||||::|:|||||
  Rat   438 CHAEIVARRAFLHFLYTQLELHLSKHQEDPERSIFIRVKEG--GYRLRENILFHLYVSTSPCGDA 500

  Fly   439 RIFSPHE--NDTGVDKHPNRKARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDK 501
            |:.||:|  .|....||..||.||.|||||||||||:||:....:|||||:|.|::|:||||:||
  Rat   501 RLNSPYEITIDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTWDGILLGEQLVTMSCTDK 565

  Fly   502 IARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNKPRLAL 566
            ||.||::|:||:||...|||||||||::|||.|..|:.|.:..|:| .|..||..|..|:|.|:.
  Rat   566 IASWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHLARVMSHRME-GIGQLPASYRQNRPLLSG 629

  Fly   567 VTSAEPRNQAKAPNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVK----YGFLMANLP 627
            |::||.|...|:|:|..||.:|..:||::|:.||:...|..||:.|..|..:    :|.|...:|
  Rat   630 VSNAEARQPGKSPHFSANWVVGSADLEIINATTGKRSCGGSSRLCKHVFSARWARLHGRLSTRIP 694

  Fly   628 GILVRKVTTDYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLA 680
            |  .....:.|.:.|.....||..|.:||.||::..||:|::||.|||:|.|:
  Rat   695 G--HGDTPSMYCEAKRGAHTYQSVKQQLFKAFQKAGLGTWVRKPPEQDQFLLS 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	31/61 (51%)
		DSRM_SF	213..>259	CDD:412133	12/46 (26%)
		ADEAMc	306..677	CDD:214718	178/379 (47%)
Adarb2	NP_579836.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		R-domain (ssRNA-binding). /evidence=ECO:0000250	23..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..105		10/40 (25%)
		DSRM	126..190	CDD:238007	32/63 (51%)
		DSRM	285..>332	CDD:214634	13/46 (28%)
		ADEAMc	367..743	CDD:214718	178/380 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	356	1.000	Domainoid score	I949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1232
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	1	1.000	-	-		FOG0002274
OrthoInspector	1	1.000	-	-		otm46085
orthoMCL	1	0.900	-	-		OOG6_104480
Panther	1	1.100	-	-	O	PTHR10910
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1704
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970