Protein Alignment Adar and ADAR

DIOPT Version :10

• Sequence 1: NP_001368969.1
• Gene: Adar / 31130
• FlyBaseID: FBgn0026086
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001351974.1
• Gene: ADAR / 103
• HGNCID: 225
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 823
• Identity: 221/823 - (26%)
• Similarity: 347/823 - (42%)
• Gaps: 233/823 - (28%)

  Fly    62 PVSAPSDINMNGYNRKLPQKRGY-------------------------------EMPKYSDPKKK 95
            |......::.||     |.|.||                               |||.:......
Human   438 PARLKPPVHYNG-----PSKAGYVDFENGQWATDDIPDDLNSIRAAPGEFRAIMEMPSFYSHGLP 497

  Fly    96 MCKERIPQPKNTVAMLNELRHGLI-----------YKLESQTGPVHAPLFTISVEVDGQKY-LGQ 148
            .|.   |..|.|...|.....||:           :.:..|:||.|.|.|...|.::|::: ..:
Human   498 RCS---PYKKLTECQLKNPISGLLEYAQFASQTCEFNMIEQSGPPHEPRFKFQVVINGREFPPAE 559

  Fly   149 GRSKKVARIEAAATALRSFIQFKDGAVLSPLKPAGNLDFTSDEHLENDVSKSAITVDGQKKVPD- 212
            ..|||||:.:||..|:...::      .:..|.:|..:.:|....|.:..|   |.:.|...|.
Human   560 AGSKKVAKQDAAMKAMTILLE------EAKAKDSGKSEESSHYSTEKESEK---TAESQTPTPSA 615

  Fly   213 ------KGPVMLLYE----LFNDVNFECINIDGAQNNCRFKMTVTINEKKFDG-TGPSKKTAKNA 266
                  |.||..|.|    |.|...|..::.:|..:..:|:..|.:..:.|.. :.||||.||..
Human   616 TSFFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHEPKFQYCVAVGAQTFPSVSAPSKKVAKQM 680

  Fly   267 AAKAALASLCNISYSPMV---VPQKNVPLPIDDKSSSM-----------------------ELPQ 305
            ||:.|:.:|...:.:.|.   .|:..:...:|:..|.|                       |..:
Human   681 AAEEAMKALHGEATNSMASDNQPEGMISESLDNLESMMPNKVRKIGELVRYLNTNPVGGLLEYAR 745

  Fly   306 IH----------------------------------------------ADTIGRLVL---EK--- 318
            .|                                              ||...|:::   ||
Human   746 SHGFAAEFKLVDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQEAADAALRVLIGENEKAER 810

  Fly   319 --FMEVI---------------KGQEAYSR----------------------------------R 332
              |.||.               :..||..:                                  |
Human   811 MGFTEVTPVTGASLRRTMLLLSRSPEAQPKTLPLTGSTFHDQIAMLSHRCFNTLTNSFQPSLLGR 875

  Fly   333 KVLAGIVM---TENMNFCEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQL 394
            |:||.|:|   :|:|..    |:|:.||.:||.|:.:|:.|..:||.||||:|||..:::||::|
Human   876 KILAAIIMKKDSEDMGV----VVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSEL 936

  Fly   395 DLQCNQATAYQSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNR--- 456
             ::.|..||..|||.....|: ..::|..|.|||||:||||||..:|....:|..::...:|
Human   937 -MKYNSQTAKDSIFEPAKGGE-KLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAMESTESRHYP 999

  Fly   457 ----KARGQLRTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSS 517
                ..:|:||||:|:|||||||:|||.:.||||:..|:||.||||||||.|||::|:||:||:.
Human  1000 VFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTH 1064

  Fly   518 IIEPVYLHSIVLGSLLHPEHMYRAVCGRIEKS----IQGLPPPYHLNKPRLALVTSAEPRNQA-K 577
            .::|:||.|:.||.|....|:.||:|.|:.:.    ..||..|:.:|.|::..|:..:.:.|: |
Human  1065 FLQPIYLKSVTLGYLFSQGHLTRAICCRVTRDGSAFEDGLRHPFIVNHPKVGRVSIYDSKRQSGK 1129

  Fly   578 APNFGINWTIGD-TELEVVNSLTGRTIGG---QVSRITKQAFFVKYGFLMANLPGILVRK--VTT 636
            .....:||.:.| .:||:::...| |:.|   ::||::|:..|:    |...|.....|:  :..
Human  1130 TKETSVNWCLADGYDLEILDGTRG-TVDGPRNELSRVSKKNIFL----LFKKLCSFRYRRDLLRL 1189

  Fly   637 DYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGL 679
            .||:.|...:||:.||.......|....|:|:.||.|:..|.|
Human  1190 SYGEAKKAARDYETAKNYFKKGLKDMGYGNWISKPQEEKNFYL 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	21/73 (29%)
		DSRM_SF	213..>259	CDD:444671	12/50 (24%)
		ADEAMc	306..677	CDD:214718	150/494 (30%)
ADAR	NP_001351974.1	z-alpha	144..210	CDD:280459
		z-alpha	304..368	CDD:280459
		DSRM_DRADA_rpt1	511..581	CDD:380742	18/75 (24%)
		DSRM_DRADA_rpt2	622..692	CDD:380743	22/69 (32%)
		DSRM_DRADA_rpt3	734..804	CDD:380744	5/69 (7%)
		ADEAMc	848..1231	CDD:214718	139/393 (35%)