DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adar and adad1

DIOPT Version :9

Sequence 1:	NP_001368969.1	Gene:	Adar / 31130	FlyBaseID:	FBgn0026086	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001116945.1	Gene:	adad1 / 100144718	XenbaseID:	XB-GENE-493326	Length:	584	Species:	Xenopus tropicalis

Alignment Length:	685	Identity:	174/685 - (25%)
Similarity:	282/685 - (41%)	Gaps:	183/685 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NMNGYNRKLPQKRGYEMPKYSDPKKKMCKERIPQPKNTVAMLNELRHGLIY--------KLESQT 126
            |:|...|.       .:|.::    :|.|:.:|.....|.:.:.:.....|        |:...|
Frog     4 NVNWIQRS-------SVPSFA----QMLKKNLPAQAPAVNLSSTVSTCCPYVEPDCGTAKVTQIT 57

  Fly   127 GPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATAL------RSF-IQFKDGAVLSPLKPAGN 184
            |....|..                ||.|  :.|:.::|      :.| ::::.|    .|.|...
Frog    58 GNFREPFL----------------SKMV--VPASLSSLPPRKVTKEFVVKYRRG----DLNPVSA 100

  Fly   185 L-DFTSDEHLENDVSKSAITVDGQKKVPDKGPVMLLYELFNDVNFECINIDGAQNNCRFKMTVTI 248
            | .|...:.:|.|:.::..|          |.|...|..|      |..|||.:    :|
Frog   101 LYQFAQMQRMEIDLKETVTT----------GNVFGAYFAF------CAVIDGIE----YK----- 140

  Fly   249 NEKKFDGTGPSKKTAKNAAAKAALASL---------------CNISYSPMVVPQKNVPLPIDDKS 298
                 .|.|.:||.||..||:.||..|               .||..:|.::|.|.   .:..::
Frog   141 -----TGMGQNKKEAKANAAQLALDELLLHEDSELTATHPESLNIMENPPLIPLKP---KVTTET 197

  Fly   299 SSMELPQ------IHADTIGRLVLEKFMEVI-KGQEAYSRRKVLAGIVMTE-NMNFCEAKVISVS 355
            |::...:      || :.|..::.|.|..:| |..|..|....||..|:.: ..|:   :|::|.
Frog   198 STISRARTDKRTFIH-EKISSIIKETFTNLISKYPEYESCGSSLAAFVIEKGGQNW---EVVAVG 258

  Fly   356 TGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDL--QCNQATAYQSIFVRNTDGQYPY 418
            || :...|:.:..:|.||:||||.:|:||.||:|.|.||.|  ..|.....:|||........ .
Frog   259 TG-EFNYGQSLQSDGRVLHDSHAIVVARRSLLRYFYRQLLLFYSGNNGMMDKSIFCTEPATNL-L 321

  Fly   419 KLKSGVHFHLYINTAPCGDAR-----IFSPHENDTGVDKHPNRKARGQLRTKIESGEGTIPVKSS 478
            .||...:..||:|..|.|.|:     ..|||    .:..|   :|..:|...:......||....
Frog   322 ALKPNFNIFLYMNQLPKGAAQTNPQLCLSPH----SLSAH---EANDKLSLHVSVEGKNIPAAYY 379

  Fly   479 DGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSIVLGSLLHPEHMYRAVC 543
            .|...       ..|.:||.:||:.||.::|:||:|||..|:|||:.:|::|:         |.|
Frog   380 SGEIV-------HNLYSMSSTDKLTRWEVLGVQGALLSVFIQPVYISTIIVGN---------AAC 428

  Fly   544 G-----------RIEKSIQG-LPPPYHLNKPRLALV-----TSAEPRNQAKAPNFGINWTIGDTE 591
            .           ||:.::.. ||..|.:|:|.:::|     |:.:|.|:    :..:||:.||..
Frog   429 SDTRGLEIAVKQRIDDALTSKLPMFYLVNRPYISIVSSTHQTNMDPVNR----SLSLNWSQGDAC 489

  Fly   592 LEVVNSLTGRTI------GGQ--VSRITKQAFFVKYGFLM------ANLPGILVRKVTTDYGQTK 642
            :|||:::.|:|:      .|.  .||:.|.|...::..::      |..|.:       .|.:.|
Frog   490 VEVVDAVRGKTVERSPFKSGSCLASRLCKAAMLCRFNLVVKESKREAIAPDL-------SYHEAK 547

  Fly   643 ANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEF 677
            .....||.||..|.:.||::..|||:.||...|||
Frog   548 HLAGPYQEAKCLLKAYFKQQGFGSWIVKPPIIDEF 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adar	NP_001368969.1	DSRM_STRBP_RED-like_rpt1	105..167	CDD:380694	11/75 (15%)
		DSRM_SF	213..>259	CDD:412133	11/45 (24%)
		ADEAMc	306..677	CDD:214718	119/410 (29%)
adad1	NP_001116945.1	DSRM	97..162	CDD:214634	25/94 (27%)
adad1	NP_001116945.1	A_deamin	256..576	CDD:280326	102/355 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274045at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010