DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3795 and F12

DIOPT Version :9

Sequence 1:	NP_001284790.1	Gene:	CG3795 / 31128	FlyBaseID:	FBgn0025378	Length:	305	Species:	Drosophila melanogaster
Sequence 2:	NP_000496.2	Gene:	F12 / 2161	HGNCID:	3530	Length:	615	Species:	Homo sapiens

Alignment Length:	288	Identity:	78/288 - (27%)
Similarity:	125/288 - (43%)	Gaps:	53/288 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PSQRQDRPSDFQFLVTGG-------YRPDTNDLVKYT---VSLRMGKP--KKFFGDNHFCAGTIF 84
            |::|:..||    |...|       .|...:.:.:..   |:||...|  ...:..:.||||::.
Human   342 PAKREQPPS----LTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLI 402

  Fly    85 SERAILTAAHCMFSNRRKLKAKKLMVVAGTPRRLLKSSTTQIIEAEELLPHPKYKKGKSQKYDIG 149
            :...:||||||:   :.:...:.|.||.|..||.......|.:.......|..:.. .|.::|:.
Human   403 APCWVLTAAHCL---QDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSP-VSYQHDLA 463

  Fly   150 LILLEADLSLGDAVAKIPLYNKV--------PVAGAPCSIVGWG----------TVIQFGPLPDE 196
            |:.|:.|.. |......|....|        |.....|.:.|||          :.:|...:|
Human   464 LLRLQEDAD-GSCALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVP-- 525

  Fly   197 AINGDMQILPDTFCEKLLGWSNAGMLCANDKHDSDVDSCQGDSGGPLICDNM-------VTGIVS 254
            .::.:....||.....:|    .|||||... :...|:|||||||||:|::.       :.||:|
Human   526 FLSLERCSAPDVHGSSIL----PGMLCAGFL-EGGTDACQGDSGGPLVCEDQAAERRLTLQGIIS 585

  Fly   255 FGMGCGEPDSAGIYTDVYHFRDWITENS 282
            :|.|||:.:..|:||||.::..||.|::
Human   586 WGSGCGDRNKPGVYTDVAYYLAWIREHT 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3795	NP_001284790.1	Tryp_SPc	60..281	CDD:238113	70/250 (28%)
CG3795	NP_001284790.1	Tryp_SPc	60..278	CDD:214473	68/247 (28%)
F12	NP_000496.2	FN2	41..88	CDD:128373
		EGF_CA	96..131	CDD:238011
		FN1	133..173	CDD:238018
		EGF	178..206	CDD:278437
		Kringle	217..295	CDD:278480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		6/20 (30%)
		Tryp_SPc	372..609	CDD:214473	68/248 (27%)
		Tryp_SPc	373..612	CDD:238113	70/250 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910