DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrc4c and Fili

DIOPT Version :9

Sequence 1:	NP_001101223.1	Gene:	Lrrc4c / 311236	RGDID:	1311013	Length:	640	Species:	Rattus norvegicus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	174/725 - (24%)
Similarity:	273/725 - (37%)	Gaps:	210/725 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat    28 VVLLALQLLVVAGLVRAQTCPSVCSC--SNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQI 90
            |:||.|..||:........|||.|.|  ....|:.:||...|.:||..::..|:.:||..|:|:.
  Fly    23 VLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIRT 87

  Rat    91 IKVN-----------------------SFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELF 132
            ::.:                       :|::...|..|.||||.:.::...||.||.||..|:|.
  Fly    88 LEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDLS 152

  Rat   133 DNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAF-------------NR---IP--------S 173
            .||:.|:...|...|:.|.||.|.||.|.|:....|             ||   :|        :
  Fly   153 FNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLHA 217

  Rat   174 LRRLD----------------LGELKRLS----YISE---GAFEGLSNLRYLNLAMCNLREIP-- 213
            |:.||                |.||..||    .:||   .|||||.:|::|:|:..||..:|
  Fly   218 LKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPTQ 282

  Rat   214 NLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ-IQVIERNAF-DN--LQSL----- 269
            .|:.|..|..|:|.||..|.:...:|..|.||::|.:.:.. :|.|:..|| ||  ||:|
  Fly   283 QLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNNN 347

  Rat   270 -----------------VEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIR 317
                             :|:.:..|:|..|....| |:..|::::|..||..|||.:||| |.:
  Fly   348 PQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQF-PVDQLQKLYLGDNPLQCNCSLLWL-WRL- 409

  Rat   318 DMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLT 382
                              :.|.:.|              |:|..: :...|..|.|...|...
  Fly   410 ------------------VTGNFEG--------------VDPGME-HAAGGAVAALAKEADDE-- 439

  Rat   383 SVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLN----V 443
                                  .|:|..              |.:.|...|....:|.:.    |
  Fly   440 ----------------------ELADEA--------------TAVASTDDGVAALAAYIAEQHIV 468

  Rat   444 TAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTIP 508
            .|..||             |||..|..|:.:|.. :.::..:...:...:.....|:..|..|:.
  Fly   469 NALHTT-------------EPSAYELATSSSNRN-SGILRMDRQQIGCDIWRDKVRTRRKLLTMS 519

  Rat   509 VTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVIFYKMR--KQHHRQNH-HAPTRTVE-II 569
            ..:|.  .|.  .::.....:|.|.    |:|.:.:.:.|.:|  |:..:..| ..|.||.: ||
  Fly   520 EGEIT--CPA--HIVTVVCAVITCL----LVAMIGISVLYYLRFVKRRRKLLHERGPMRTSKSII 576

  Rat   570 NVDDEI-TGDTPMESHLPMPAIEHEHLNHYNSYKSPFNHTTTVNTINSIHSSVHEPLLIRM---N 630
            ||.|.| .|..|....|.| ::.....||.|......|:.....|:.: |...|:.:.::.   |
  Fly   577 NVHDRILQGHNPGGLGLGM-SMTLGGGNHVNGLGMTLNYPHHAQTLQA-HHHYHQAMPLQSHGGN 639

  Rat   631 SKDNVQETQI 640
            .....|:|.:
  Fly   640 GNHEYQQTTL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrc4c	NP_001101223.1	LRRNT	47..80	CDD:214470	12/34 (35%)
		PPP1R42	65..235	CDD:411060	69/241 (29%)
		leucine-rich repeat	78..101	CDD:275380	6/45 (13%)
		leucine-rich repeat	102..125	CDD:275380	10/22 (45%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		leucine-rich repeat	150..173	CDD:275380	12/46 (26%)
		leucine-rich repeat	174..198	CDD:275380	15/46 (33%)
		leucine-rich repeat	199..220	CDD:275380	8/22 (36%)
		LRR_8	220..279	CDD:404697	22/84 (26%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..268	CDD:275380	9/26 (35%)
		LRR_8	267..>301	CDD:404697	10/55 (18%)
		leucine-rich repeat	269..290	CDD:275380	6/42 (14%)
		LRRCT	301..>339	CDD:214507	9/37 (24%)
		IG	360..443	CDD:214652	10/86 (12%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	5/21 (24%)
		leucine-rich repeat	98..121	CDD:275380	1/22 (5%)
		LRR_8	120..180	CDD:404697	25/59 (42%)
		leucine-rich repeat	122..145	CDD:275380	10/22 (45%)
		leucine-rich repeat	146..169	CDD:275380	8/22 (36%)
		LRR	<161..>354	CDD:227223	57/192 (30%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	3/22 (14%)
		leucine-rich repeat	218..265	CDD:275380	15/46 (33%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	8/23 (35%)
		LRR_8	337..397	CDD:404697	12/60 (20%)
		leucine-rich repeat	339..360	CDD:275380	3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4398
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960