DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ext2 and sotv

DIOPT Version :9

Sequence 1:	XP_006234638.2	Gene:	Ext2 / 311215	RGDID:	1307707	Length:	791	Species:	Rattus norvegicus
Sequence 2:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	347/715 - (48%)
Similarity:	478/715 - (66%)	Gaps:	31/715 - (4%)

- Green bases have known domain annotations that are detailed below.

  Rat    89 PRMKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSIESSSDGGVE-KRS----IREVPVVRLTADS 148
            ||   :|.:..:|...:|::.|.|.  |..|..| .|..||... ||.    |.::..::..|.:
  Fly    22 PR---EHILNCLTYGLLVIVALCAG--FLLWDLS-SSPRDGFFHGKRDSHTLILDLEHIQELAVN 80

  Rat   149 PIPER--GDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDDAGVPVSSAISREYNELLTAIS 211
            |..|:  .:::|....|.::|:|   ..:::|||||||:::||:.....::.:|.||.::|.|:.
  Fly    81 PEAEQRARNVNCTFWDCLNIYKC---EHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVL 142

  Rat   212 DSDYYTDDISRACLFVPSIDVLNQNPLRIKETAQALAQLPRWDRGTNHLLFNMLPGGPPDYNTAL 276
            .|.|||.:.:.||||:||:|:||||.........|||.|..||||.||::|||||||.|.|||.|
  Fly   143 KSRYYTSNPNEACLFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPGGAPSYNTVL 207

  Rat   277 DVPRDRALLAGGGFSTWTYRQGYDVSIPVFSPLSAEVALPEKAPGSRRYFLLSSQMAIHPEYREE 341
            ||..|.|::.||||.:|:||.|:||:|||:||  ..|.....|...|::.|:.:|:.|.|.:...
  Fly   208 DVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSP--RLVRQHAHATAQRKFLLVVAQLNILPRFVRT 270

  Rat   342 LEALQAKHRESVLVLDKCTNLSEGVLSIRKRC---HQHQVFDYPQVLQEATFCTVLRGARLGQAV 403
            |..|...|.|.:|:|..|.|     |.:..||   ..|:..:||::|....||.:.|..|:||..
  Fly   271 LRELSLAHSEQLLLLGACEN-----LDLTMRCPLSQHHKSLEYPRLLSRGKFCLLGRSLRMGQPD 330

  Rat   404 LSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVIPEEKMSDVYSILQNIPQRQIEEMQRQARWF 468
            |.:::...|:||:..|:|:|||.:|:||..|||.|.|.::..|...|:.|...:|.|||:|.:|.
  Fly   331 LVEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWL 395

  Rat   469 WEAYFRSIKAIALATLQIINDRIYPYAAISYEEWN--DPPAVKWASVSNPLFLPLIPPQSQGFTA 531
            :..||:.:|.:.|..|:::..||:|..|.|..:||  |..|   .|..||||||.:.|:||||||
  Fly   396 FSKYFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNA---RSTFNPLFLPSLAPKSQGFTA 457

  Rat   532 IVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVVRTAENKLSNRF 596
            ::||||||||||.:|.:::.||||..:||:||||.|:||..|.:|.|..|||:.:|.||||||||
  Fly   458 VILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRF 522

  Rat   597 FPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTN 661
            :||.||||||:|.|||||||||:|||.|||||||||||.:||:|.|:|:|::...:|.|||||||
  Fly   523 YPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTN 587

  Rat   662 EVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFK 726
            ::|||||||||:|||::::||:.||||||:|||.|||||||||||||||:|....||||||||||
  Fly   588 QISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFK 652

  Rat   727 CPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL 791
            |||||..:.||.|..||.|||.||::|:.::|.|||:.||.||||||::|:||:|||.:.:||||
  Fly   653 CPECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKRYNDIGSL 717

Rat 792 791
Fly 718 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ext2	XP_006234638.2	Exostosin	173..453	CDD:281069	117/282 (41%)
Ext2	XP_006234638.2	Glyco_transf_64	529..763	CDD:286358	156/233 (67%)
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	117/281 (42%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	156/233 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350603
Domainoid	1	1.000	367	1.000	Domainoid score	I890
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H345
Inparanoid	1	1.050	687	1.000	Inparanoid score	I668
OMA	1	1.010	-	-		QHG48639
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	1	1.000	-	-		FOG0008338
OrthoInspector	1	1.000	-	-		oto96916
orthoMCL	1	0.900	-	-		OOG6_106435
Panther	1	1.100	-	-	LDO	PTHR11062
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910