Protein Alignment CG32809 and SRCIN1

DIOPT Version :9

• Sequence 1: NP_001245466.1
• Gene: CG32809 / 31121
• FlyBaseID: FBgn0023531
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: XP_016880658.1
• Gene: SRCIN1 / 80725
• HGNCID: 29506
• Length: 1479
• Species: Homo sapiens
• Alignment Length: 1598
• Identity: 360/1598 - (22%)
• Similarity: 563/1598 - (35%)
• Gaps: 550/1598 - (34%)

  Fly    11 SASSNQSVGGSSSSSSKKKRKGREGEDWQNEAKSGRLPSNEQGGDERRRAMR-RDDPRRHTLGG- 73
            :|.|.:::.|...:.:.:||     :.:.:..|| :.|       :...|:| :.|..|..:||
Human    46 AAQSLEALSGLQKADADRKR-----DAFMDHLKS-KYP-------QHALALRGQQDRMREQVGGW 97

  Fly    74 ---DMLVYGSQHPHAH-QMAPQ-----QQRAMDLEMSTRAQKNKKNQPMRGYAPVNQGPLFDDDP 129
               .:.:..|...|.| ..||.     .|:.......||:.::            .||.    .|
Human    98 TVDPVCLLSSLCSHLHGDSAPSGAGQPAQQPNYWSFKTRSSRH------------TQGA----QP 146

  Fly   130 GI-----------------MSEVETASTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRSET 177
            |:                 |||.| ...||.|..:.|.|||:.|:.|:|..|..|::|||:..||
Human   147 GLADQAAKLSYASAESLETMSEAE-LPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEET 210

  Fly   178 KRALLPNEITSIDTVRALFVRSFPRQLTMSYLEGPNVKIYIHDASKDMFYELEDVRSHLREIRDR 242
            :|..:.:|::|:||:.||....||::|||..|:.||..|.|.|.::::|||||||    |:|:||
Human   211 RRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDV----RDIQDR 271

  Fly   243 SVLRLF--ESTEVAAPPQILPGG----------------------------------PGIPQPLP 271
            |:::::  |....|.|...|..|                                  ||:|..||
Human   272 SIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLP 336

  Fly   272 QAQANWDQDQSYFS----EPEFDSDYKHQHIHKS--KIGKQPAPYYVGSSQT--LPR-------- 320
            ....:....:|..|    .|   ..|....:|.:  ::|..||...|..|.:  |.|
Human   337 SGLQSGSPSRSRLSYAGGRP---PSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDED 398

  Fly   321 --------------GMYSS-----ERNKVSMGAPV-KPLR-----SLNPRGSMEPLFPYT----- 355
                          |:|:.     ...::|:.|.. .|..     .|..|||:..|..|:
Human   399 LASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQ 463

  Fly   356 ---PDQLYSIP--------DGY-----TSSPER-----SSRGNYEEPY--YSQYGTRGAVV---- 393
               .|.||...        |||     .|||::     :..|....|:  ||...:||:.|
Human   464 SDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSF 528

  Fly   394 ------APIIDEEQSDGTMTEDQYALYG-----IKVGPGPNRLTHRGNQI--------YDP---- 435
                  :.:..|.....|.:....:..|     :..|||...|...|..:        .||
Human   529 RKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRRDPMLRG 593

  Fly   436 --TRPEDLHRIRVEHMERQLANLTGLVQKALVNQNPQIAPLAVPTLDPNYLVVPSQMQANGSGDE 498
              .:...|.|.|:|.||:|:|:||||||.||:..:....|
Human   594 EVAQTPFLPRERMEAMEKQIASLTGLVQSALLRGSEPETP------------------------- 633

  Fly   499 LYIREKAPKLGKNSCQKSVSFEKSVSFSDDIQGIPKSHNPLHAAETKPTKPAIKSSTLPRTSSQE 563
                                       |:.|:|...:..|     :.|.....:||.....|.
Human   634 ---------------------------SEKIEGSNGAATP-----SAPCGSGGRSSGATPVSG-- 664

  Fly   564 RDRLKPPPPPKPIVLAQTAHPNYRADIALAPEVYNHLRGLQKKAKDLRMEVRTLRRLSQAQAVAV 628
                  ||||     :.::.|..:.......::..||||||..|.|||.:::.||:| |.|.
Human   665 ------PPPP-----SASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKL-QLQN--- 714

  Fly   629 REDIKGTFMRIRATLLASSGSFWDHQGDQDATRISREEELYKQEVIR-------LEKDLSDLEGS 686
            :|.::....|..|.|..........|.|.    :.|:..|.::|.:|       :.:.|:|||.|
Human   715 QESVRALLKRTEAELSMRVSEAARRQEDP----LQRQRTLVEEERLRYLNDEELITQQLNDLEKS 775

  Fly   687 VENLRGEVINRRTRVNMTAVEDMALVLSRASKTVAELKLKFPSLSNGLRCILSNEMEKVVREEKF 751
            ||.::.:|.:....|....:|:.||||.:..:|:.|||..||.|.:.:|.:|..|:|.|    ||
Human   776 VEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAV----KF 836

  Fly   752 LKEEPDRLESALRRCKKLTGTLVTLKRLASVQEQRLPPNEPTISE-------ETP--RSADISAP 807
            |||||.||:..|:||:.:|.||..::|  .|.|...||....:|:       ||.  :|.|.
Human   837 LKEEPQRLDGLLKRCRGVTDTLAQIRR--QVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDF--- 896

  Fly   808 DKPIPTPRMGSFALSG----------GLAPENALDA----LLDELKTFSKPIAQQQQQQQQQQQQ 858
            :.|.|:|.:....|||          |..|...||.    .:|  |..|...|::..::::....
Human   897 EMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVD--KAVSVEAAERDWEEKRAALT 959

  Fly   859 QQ---------QQHQHQQLYEIRPEDSASD----------------ESAQAAVQSTV------TT 892
            |.         ::.|.:.|..|...|.||.                ...|.|...|.      :.
Human   960 QYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSD 1024

  Fly   893 QISQARLYTE----------------ASVNVQQATTGSMVIAVASGTVSAQAQAQRGVLTHQQSQ 941
            :::..|..||                :|..:....||.:|:.           :::.....::::
Human  1025 ELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVT-----------SKKDSAFIKKAE 1078

  Fly   942 SQAQLMVHTNMGSLRRLHSYPSESDGELPGPPPTGP-------------------RASETSSSTS 987
            |: :|.|......|||..|       |:..|..|.|                   ...|.||.:|
Human  1079 SE-ELEVQKPQVKLRRAVS-------EVARPASTPPIMASAIKDEDDEDRIIAELEVFERSSVSS 1135

  Fly   988 LANGGSSSKPPVPERNAELI-TKVGHKRIPPP----PPPRTSSRS-------------PLASP-- 1032
            |        ||.|.|  :|| |.:..:.:.||    |.|....|:             |:::|
Human  1136 L--------PPTPRR--QLIPTLLSPQDLGPPGGSAPGPTRKHRATEPGEREVALSAFPVSTPHF 1190

  Fly  1033 ------------------TSPNVPPNQAAAATVNLIPNSNSNASANANANANSNATGNK---GIV 1076
                              .:|| ||:...|....|.|.:.........|::.....|.:   |:|
Human  1191 QAAPGPRAFCVPRIILTECAPN-PPSPPEARLEELGPRTAPTPRPQTLADSTRGWDGPQSPPGVV 1254

  Fly  1077 GETTSVVSGDTSS-------------GDNSSGNESGNDHVQ-----------RQVALEMRHQELL 1117
            |||    ||..||             |...|..|.|...||           .....:...:|:|
Human  1255 GET----SGPRSSFMPRKEGAALKRLGGGGSSLEDGGARVQCPQGPAQDGTPETSTADTYPEEIL 1315

  Fly  1118 KKQKMLQEQYQRLQQMSKLPSVDVASSS-----SSSAQDIASGSNTLRKLGSETNIQQKIAALSL 1177
            |      :.....|..|:......|::|     .::||.:.|...|||:|
Human  1316 K------DSGHDAQTCSREHQGQAAANSGRTTWGATAQQMDSLEETLREL--------------- 1359

  Fly  1178 ACETSGAAAAAAAAAAAAATNGGVVASDATSGA---------IGGGG---------GA----GAA 1220
                           .|..:|.|...:..:.|:         .|||.         ||    .|.
Human  1360 ---------------EATLSNMGTGPAMGSPGSPPPLPLRPQSGGGSVPPMKVVTPGASRLKAAQ 1409

  Fly  1221 GAAGASAAAAHSNSNSNSNLNLNLNSQHQTATTTTKQL 1258
            |.||:...:.|....:.   .:.:.:|.| ||..:|::
Human  1410 GQAGSPDKSKHGKQRAE---YMRIQAQQQ-ATKPSKEM 1443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32809	NP_001245466.1	AIP3	170..>247	CDD:281852	35/76 (46%)
SRCIN1	XP_016880658.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155714
Domainoid	1	1.000	93	1.000	Domainoid score	I7554
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2988
Isobase	1	0.950	-	0	Normalized mean entropy	S8094
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002249
OrthoInspector	1	1.000	-	-		otm41335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22741
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.030