DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32809 and si:ch211-285f17.1

DIOPT Version :9

Sequence 1:	NP_001245466.1	Gene:	CG32809 / 31121	FlyBaseID:	FBgn0023531	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	XP_021325949.1	Gene:	si:ch211-285f17.1 / 562465	ZFINID:	ZDB-GENE-000607-77	Length:	2066	Species:	Danio rerio

Alignment Length:	1501	Identity:	349/1501 - (23%)
Similarity:	544/1501 - (36%)	Gaps:	511/1501 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KSKDKSASSNQSVG---GSSSSSSK------KKRKGR----EGEDWQNEAKSGRLPS-NEQGGDE 56
            |.:|:::.|...:.   ||:::.|:      |..||.    ..||.::..:..::.| |..|...
Zfish    69 KEEDEASQSKSRISPPKGSTTNVSQQQVTQPKPLKGNLKVTSSEDSEHLTRKQQVVSANSSGNRC 133

  Fly    57 RRRAMRRDDPRRHTLGG-------------DM-------LVYGSQ-HPH------AHQMAPQQQ- 93
            ..::.|...|||||:||             ||       |.:..| :||      .||...::|
Zfish   134 EAKSSRAGVPRRHTVGGARSSREILAMQPSDMDKKREAFLEHLKQKYPHHASAIMGHQERLREQS 198

  Fly    94 -----RAMDLEMS---------------TRAQKNKKNQPMRGYAPVNQGPLFDD--DPG------ 130
                 .|:..|:.               ||..|.....|    :||   |:|.|  :.|
Zfish   199 FQRMLSALHSEIDIQRYLLKIQAAGSRRTRGSKQSVGCP----SPV---PVFVDQVEHGSLVSLD 256

  Fly   131 ---IMSEVETASTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRSETKRALLPNEITSIDTV 192
               :|||.: ....|.||.:.|:||||||:.::|.:|.||:::|||..:||:..:||||||:||:
Zfish   257 ALEVMSECD-MPLAFTRGSRSRASLPVVRSTNQTKDRSLGVLYLQYGDDTKQIRMPNEITSVDTI 320

  Fly   193 RALFVRSFPRQLTMSYLEGPNVKIYIHDASKDMFYELEDVRSHLREIRDRSVLRLFESTEVAAPP 257
            |||||.:||.||.|..||.|:..||:.|.:::::|||.||||    |.|.|.|:::...    |.
Zfish   321 RALFVSAFPHQLNMKMLESPSTAIYVKDETRNVYYELTDVRS----ITDHSCLKVYHKD----PA 377

  Fly   258 QILPGGPGIPQPLPQAQANWDQDQSYFSEPEFDSDYKHQHIHKSKI--GKQ-----------PAP 309
            .....|   |:|     :|.|                 ..:|:..|  |:.           |.|
Zfish   378 HAFSHG---PRP-----SNGD-----------------TRVHREMIFAGRDGHPLRNPPMGPPPP 417

  Fly   310 YYVGS-SQTLPRGMYSS--------------------ERNKVSMGAP----------------VK 337
            :..|| |.|.|.||..|                    ||...::.||                ||
Zfish   418 HMQGSMSPTTPHGMPPSPSRIPFGPRNPGGGVATMPRERAGHTLPAPARASSPCPSAILERRDVK 482

  Fly   338 P-------LRSLNPRGSMEPLFPY-------TPDQL-----------YSIPDGYTSSPERSSRGN 377
            |       ..|||.|.......||       .||.:           ||.|......|:...|..
Zfish   483 PDEDVAAKTMSLNTRAESHYADPYMLLHHAPPPDTVDHAYHRATMRSYSNPSVPLEPPDHLFRQK 547

  Fly   378 YEEPYYSQYGTRGAVVAP-------IID--EEQSDGTMTEDQY---------------ALYGIKV 418
            .........|::....:|       ::|  ..|...:||.::.               |:...:.
Zfish   548 SRNSQLPMLGSKTPPPSPHRMGEMRMVDIHTVQPQSSMTLERASPVRQSFRKEAPPMDAMVKARG 612

  Fly   419 GPG----PNRLTHRGNQIYDPTRPEDLHRIRVEHMERQLANLTGLVQKALVNQNPQIAPLAVPTL 479
            |.|    |:...|  |.:..||.|:.  |.|::.||.|:|:||||||.||:..|
Zfish   613 GMGSPATPDLQVH--NPLAPPTDPQT--RERMKAMEEQIASLTGLVQHALLKSN----------- 662

  Fly   480 DPNYLVVPSQMQANGSGDELYIREKAPKLGKNSCQKSVSFEKSVSFSDDIQGIPKSHNPLHAAET 544
                                          ..:..|..|.|:.|          ||.:|.|:..:
Zfish   663 ------------------------------STNSNKEHSSERPV----------KSGSPAHSTSS 687

  Fly   545 KPTKPAIKSSTLPRTSSQERDRLKPPPPPKPIVLAQTAHPNYRADIALAPEVYNHLRGLQKKAKD 609
            ....|.:    .|:..:...:|...|.||                :..|| ::.:|...:|...:
Zfish   688 TGGSPVL----APKVVAAPPERSPAPTPP----------------LGPAP-LHVNLHLFRKNVSE 731

  Fly   610 LRMEVRTLRRLSQAQAVAVREDIKGTFMRIRATLLASSGSFWDHQGDQDATRISR---EEELYK- 670
            ||::::.:|:|.......||..||.....|...|....      :...|.|:..|   |||.::
Zfish   732 LRLQLQHMRQLQLQNQECVRAQIKRAEQEIGVKLAEML------RRQDDPTQKQRMLVEEERHRY 790

  Fly   671 ---QEVIRLEKDLSDLEGSVENLR---GEVINRRTRVNMTAVEDMALVLSRASKTVAELKLKFPS 729
               ||  |:...|.|||..||.||   |...::|. |.:..|||.|:.|.:..:.:|.||.:||:
Zfish   791 LSMQE--RVLTQLGDLEQFVETLRTDSGPAASQRA-VTLKEVEDGAVSLRKVGENLAGLKGEFPA 852

  Fly   730 LSNGLRCILSNEMEKVVREEKFLKEEPDRLESALRRCKKLTGTLVTLKRLASVQEQRLPPNEPTI 794
            |.:.:|.:|..|:|.|    |||||||.:|:|.|:|.:.||.||..|:|.|:  :..|.|.:...
Zfish   853 LQSRMRSVLRVEVEAV----KFLKEEPHKLDSMLKRVRTLTDTLSNLRRCAT--DNLLKPTDQVC 911

  Fly   795 SEETPRSADISAPDKPIPTPRMGSFALSGGLAPENALDALLDELKTFSKPIAQQQQQQQQQQQQQ 859
            | ..|.|......:.|.|.|          :.|::::  :..|:.| |.|:.....|......||
Zfish   912 S-TPPASEKPELIESPEPAP----------VTPQSSI--VRSEVMT-SNPVVIHHAQASPVASQQ 962

  Fly   860 QQQHQHQQLYEIRPEDSASDESAQAAVQSTVTTQISQARLYTEASVNVQQATTGSMVI------- 917
            .||.........:..:|....:.|....|...||.:.:...:...|: .:..:.:::|
Zfish   963 SQQSTAPSPIPTQRRESTPSPTKQLRKPSLEQTQNNTSNGVSANGVH-GKGPSPNLIIEEIHASH 1026

  Fly   918 ------AVASGTVSAQAQAQRGVLTHQQSQSQAQLMVHTNMGSLRRLHS--YPSESDGELPGPPP 974
                  ||:......:.:.:|..|.|...|...:::.......||.:.:  .||:.:|. |.||.
Zfish  1027 SKNKNRAVSIEAAEKEWEEKRQNLGHYDGQEFERILQEAEANMLRGIPNLEVPSQLEGS-PAPPA 1090

  Fly   975 TGPRA-----------------------SETSSSTSLANGGSSSKPPVP---------------- 1000
            ..|.:                       ||..:.|      :|.|||.|
Zfish  1091 MLPASLEEVVEINEPVAAPREHDDNQPNSEKPAKT------ASEKPPKPLEKPVKPALEKPLKPS 1149

  Fly  1001 ---ERNAELITKVGHK----------RIPPPPPPR---------TSSR----------------- 1026
               :.|.|..:|...|          :.|||||||         |::|
Zfish  1150 LSIKSNLERQSKTQEKVKLQSTEKTNKSPPPPPPRRNYTTNTGMTTTRSGEVIYTSRKESVTEGE 1214

  Fly  1027 -----SPLASP---TSPNV-------PPNQAAAATVN---------------------------- 1048
                 |.::.|   |.|.|       ||..|:|.|..
Zfish  1215 EESNISTMSQPEPKTPPEVKPKPITPPPISASAITEEEDEGDKIMAELQVFQKCSVKEVGLKGLV 1279

  Fly  1049 -----------LIP-----NSNSNASANANANANSNAT--GNKGIVGETTSVVS-GDTSSGDNSS 1094
                       |:|     |:.:....|.:.:.|.|.|  .:.|::...|:.:| |.....:.|:
Zfish  1280 EPQIRELRPGVLLPLKDKKNTENQDDKNTDTDENGNNTIRQSPGVIYYVTAQISKGTPPPSEEST 1344

  Fly  1095 GNESGNDHVQRQVALEMRHQELLKKQKMLQEQYQRLQQMSK-----LPSVDVASSSSSSAQDIAS 1154
            .....:.....||:           |....:|.|..||:|.     |.::.:|:.|.:..|:..|
Zfish  1345 ERRDASQSFPSQVS-----------QINASDQSQSQQQVSNNKSDALKNIGLANFSGTQQQNQLS 1398

  Fly  1155 GSNTLR 1160
            .|.:|:
Zfish  1399 RSASLK 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32809	NP_001245466.1	AIP3	170..>247	CDD:281852	40/76 (53%)
si:ch211-285f17.1	XP_021325949.1	AIP3	298..>371	CDD:332043	40/76 (53%)
		Atrophin-1	<430..718	CDD:331285	69/363 (19%)
		AIP3	641..947	CDD:332043	107/406 (26%)
		MotB_plug	<1764..1932	CDD:330912
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590884
Domainoid	1	1.000	84	1.000	Domainoid score	I8194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3477
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002249
OrthoInspector	1	1.000	-	-		otm25602
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4503
SonicParanoid	1	1.000	-	-		X2349
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	11.070