Protein Alignment CG32809 and KIAA1217

DIOPT Version :9

• Sequence 1: NP_001245466.1
• Gene: CG32809 / 31121
• FlyBaseID: FBgn0023531
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: XP_011517854.2
• Gene: KIAA1217 / 56243
• HGNCID: 25428
• Length: 2017
• Species: Homo sapiens
• Alignment Length: 1510
• Identity: 348/1510 - (23%)
• Similarity: 541/1510 - (35%)
• Gaps: 449/1510 - (29%)

  Fly    11 SASSNQSVGGSSSSSSKKK--------RKGREG--------EDWQNEAKSGRLPSNEQG------ 53
            :||...|......:|.:||        |.|.||        :.....|:....|..|||
Human    15 AASKLPSARRDDLNSKQKKNSLGEKILRTGSEGNLVKQQQVQTAATPAQRKATPHKEQGKGNLHV 79

  Fly    54 -----------------GDERRRAMR--RDDPRRHTLGG---DMLVYGSQ--------------- 81
                             |:.|....:  |:.||||||||   ...:.|.|
Human    80 TSPEDAECRRTKERLSNGNSRGSVSKSSRNIPRRHTLGGPRSSKEILGMQTSEMDRKREAFLEHL 144

  Fly    82 ---HPH------AHQMAPQQQRAMDLEMSTRAQ------------KNKKNQPMRGYAPVNQGPLF 125
               :||      .||...:.|....:.:|.:|:            ..:...|...::|  |.|..
Human   145 KQKYPHHASAIMGHQERLRDQALKGMLISLQAELDIQRYLMKIESSQRTRSPKLSHSP--QPPSL 207

  Fly   126 DDDPGIMSEVET----------ASTGFRRGGKQRSSLPVVRTPSKTLERPLGLVFLQYRSETKRA 180
            .|....:||...          |.|.|.||.:.|:||||||:.::|.||.||:::|||..|||:.
Human   208 GDPVEHLSETSADSLEAMSEGDAPTPFSRGSRTRASLPVVRSTNQTKERSLGVLYLQYGDETKQL 272

  Fly   181 LLPNEITSIDTVRALFVRSFPRQLTMSYLEGPNVKIYIHDASKDMFYELEDVRSHLREIRDRSVL 245
            .:||||||.||:|||||.:||:||||..||.|:|.|||.|.|::::|||.|||:    |:|||:|
Human   273 RMPNEITSADTIRALFVSAFPQQLTMKMLESPSVAIYIKDESRNVYYELNDVRN----IQDRSLL 333

  Fly   246 RLFESTEVAA---PPQILPG--------------GPGIPQP---------LPQAQANWDQDQSYF 284
            :::......|   .|:.:.|              |||.|:|         :|.:..:.....|..
Human   334 KVYNKDPAHAFNHTPKTMNGDMRMQRELVYARGDGPGAPRPGSTAHPPHAIPNSPPSTPVPHSMP 398

  Fly   285 SEPEFDSDYKHQHIHKSKIGKQPAPY------YVGSSQTLPRGMYSSERNKVSMGAPVKP----- 338
            ..|             |:|     ||      .|..:.|:||...||    :.:..|:.|
Human   399 PSP-------------SRI-----PYGGTRSMVVPGNATIPRDRISS----LPVSRPISPSPSAI 441

  Fly   339 --LRSLNPRGSM--EPLFPYTPDQLYS----------------------IPDGYTS--------- 368
              .|.:.|...|  :.:..|..:..|:                      :||...:
Human   442 LERRDVKPDEDMSGKNIAMYRNEGFYADPYLYHEGRMSIASSHGGHPLDVPDHIIAYHRTAIRSA 506

  Fly   369 ----SPERSSRGNYEEPYYSQYG---------TRGAVVAPIIDEEQSDGTMTEDQYALYGIKVGP 420
                :|...:..:.|:..|.|..         |.|:...|......||..|. |.:|.|... ||
Human   507 SAYCNPSMQAEMHMEQSLYRQKSRKYPDSHLPTLGSKTPPASPHRVSDLRMI-DMHAHYNAH-GP 569

  Fly   421 ---------GPNRLTHR---GNQIY-----------------------------DPTRPEDLH-R 443
                     .|:|...:   |..:|                             ..|.|:|.. |
Human   570 PHTMQPDRASPSRQAFKKEPGTLVYIEKPRSAAGLSSLVDLGPPLMEKQVFAYSTATIPKDRETR 634

  Fly   444 IRVEHMERQLANLTGLVQKALVNQNPQIAPLAVPTLDPNYLVVPSQMQANGSGDELYIREKAPKL 508
            .|::.||:|:|:||||||.||.                                      |.|
Human   635 ERMQAMEKQIASLTGLVQSALF--------------------------------------KGP-- 659

  Fly   509 GKNSCQKSVSFEKSVSFSDDIQGIPKSHNPLHAAETKPTKPAIKSSTLPRTSSQERDRLKPPPPP 573
                   ..|:.|..| |:.:.....:.|...:|.|.........|.|..|        .||..|
Human   660 -------ITSYSKDAS-SEKMMKTTANRNHTDSAGTPHVSGGKMLSALEST--------VPPSQP 708

  Fly   574 KPIVLAQTAHPNYRADIALAPEVYNHLRGLQKKAKDLRMEVRTLRRLSQAQAVAVREDIKGTFMR 638
            .|:..:               .::..|..:::...:||::::.:|:|.......:|..:|...:.
Human   709 PPVGTS---------------AIHMSLLEMRRSVAELRLQLQQMRQLQLQNQELLRAMMKKAELE 758

  Fly   639 IRATLLASSGSFWDHQGDQDATRISREEELYKQEVIRLEKDLSDLEGSVENLRGEVINRRTRVNM 703
            |...::.:.....| ...:....:.:|.:.|..|..::.|.|.:||..||:|:.:.......|.:
Human   759 ISGKVMETMKRLED-PVQRQRVLVEQERQKYLHEEEKIVKKLCELEDFVEDLKKDSTAASRLVTL 822

  Fly   704 TAVEDMALVLSRASKTVAELKLKFPSLSNGLRCILSNEMEKVVREEKFLKEEPDRLESALRRCKK 768
            ..|||.|.:|.:..:.||.||.:||:|.|.:|.||..|:|.|    :||||||.:|:|.|:|.:.
Human   823 KDVEDGAFLLRQVGEAVATLKGEFPTLQNKMRAILRIEVEAV----RFLKEEPHKLDSLLKRVRS 883

  Fly   769 LTGTLVTLKR---------LASVQEQRLPPNEPTISEETPRSADISAPDKPIPTPRMGSFALSGG 824
            :|..|..|:|         ..:.|..:....|...:.|..:|.:.:|.....|....|
Human   884 MTDVLTMLRRHVTDGLLKGTDAAQAAQYMAMEKATAAEVLKSQEEAAHTSGQPFHSTG------- 941

  Fly   825 LAPENALDALLDELKTFSKPIAQQQQQQQQQQQQQQQQHQHQQLYEIRPEDSASDESAQAAV--Q 887
             ||.:|        |:...|::....:..|......|..|| .:..:.|..:....::..||  :
Human   942 -APGDA--------KSEVVPLSGMMVRHAQSSPVVIQPSQH-SVALLNPAQNLPHVASSPAVPQE 996

  Fly   888 STVTTQISQARLYTEASVNVQQATTGSMVIAV---ASGTVSAQAQAQRGVLTHQQSQSQAQLMVH 949
            :|.|.|:|||....:..:|      ||.:.::   ...:|||:.:|.......::.:.:.|.:.|
Human   997 ATSTLQMSQAPQSPQIPMN------GSAMQSLFIEEIHSVSAKNRAVSIEKAEKKWEEKRQNLDH 1055

  Fly   950 TNMGSLRRL---------HSYPSESDGELPGPPPTG--PRASETSSSTSLANGGSSSKPPVPERN 1003
            .|.....:|         .|.|:     |..||.||  ||.........|     |...|..|::
Human  1056 YNGKEFEKLLEEAQANIMKSIPN-----LEMPPATGPLPRGDAPVDKVEL-----SEDSPNSEQD 1110

  Fly  1004 AELITKVGHKRIPPPPPPRTSSRSPLASPTS------------PNVPPNQAAAATVNLIPNSNSN 1056
            .|   |:|.|..||||||...|..|.:..|:            .|:   .|.|::.:..|:..:.
Human  1111 LE---KLGGKSPPPPPPPPRRSYLPGSGLTTTRSGDVVYTGRKENI---TAKASSEDAGPSPQTR 1169

  Fly  1057 ASANANANANSNATGNKGIVGETTSVVSGDTSSGDNSSGNESGNDHVQRQVALEMRHQELLKKQK 1121
            |:........|..|.:...|  |||      ||.|.....|.|:                    |
Human  1170 ATKYPAEEPASAWTPSPPPV--TTS------SSKDEEEEEEEGD--------------------K 1206

  Fly  1122 MLQEQYQRLQQMSKLPSVDVASSS-------SSSAQDIASGSNTLRKLGSETNIQ---QKIAALS 1176
            ::.|    ||...|...:||.|:|       .|..:|..||:....|  .:.|::   :.:....
Human  1207 IMAE----LQAFQKCSFMDVNSNSHAEPSRADSHVKDTRSGATVPPK--EKKNLEFFHEDVRKSD 1265

  Fly  1177 LACETSGAAAAAAAAAAAAATNGGVVASDATSGAIGGGGGAGAAGAAGASAAAAHSNSNSNSNLN 1241
            :..|.      .........|.|.|..||......|.......|..............||.||::
Human  1266 VEYEN------GPQMEFQKVTTGAVRPSDPPKWERGMENSISDASRTSEYKTEIIMKENSISNMS 1324

  Fly  1242 LNLNSQHQTATTTTK 1256
            |..:|::.:..|..|
Human  1325 LLRDSRNYSQETVPK 1339

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32809	NP_001245466.1	AIP3	170..>247	CDD:281852	45/76 (59%)
KIAA1217	XP_011517854.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155713
Domainoid	1	1.000	93	1.000	Domainoid score	I7554
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2988
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002249
OrthoInspector	1	1.000	-	-		otm41335
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22741
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4503
SonicParanoid	1	1.000	-	-		X2349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	10.070