DRSC/TRiP Functional Genomics Resources

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Protein Alignment hfw and ISLR2

DIOPT Version :9

Sequence 1:NP_001259135.1 Gene:hfw / 31120 FlyBaseID:FBgn0001189 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_001123608.1 Gene:ISLR2 / 57611 HGNCID:29286 Length:745 Species:Homo sapiens


Alignment Length:182 Identity:43/182 - (23%)
Similarity:63/182 - (34%) Gaps:44/182 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 DCSNLGLVELPQRLPDNTFMLNITNNKITSL-----GDYFHTNPTY--HN--------------- 443
            ||:...|.|:|:.||.|...|:::.||||.|     .|.......:  ||               
Human    36 DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQ 100

  Fly   444 INRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFL------------NNALMDSGL 496
            :..|...:|.||| :.:...:.:...|.:.|.:|.|..:|...|            ||.|.....
Human   101 LKNLDLSHNFISS-FPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAP 164

  Fly   497 G--------RRIYLAGNKLQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMP 540
            |        ..:.|..|...|.|... .||.|.......:|:...|.|.:.|
Human   165 GTFDALSALSHLQLYHNPFHCGCGLV-WLQAWAASTRVSLPEPDSIACASPP 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hfwNP_001259135.1 LRR_8 235..294 CDD:290566
leucine-rich repeat 237..259 CDD:275378
leucine-rich repeat 260..283 CDD:275378
leucine-rich repeat 284..304 CDD:275378
leucine-rich repeat 420..443 CDD:275378 7/29 (24%)
leucine-rich repeat 444..465 CDD:275378 5/20 (25%)
leucine-rich repeat 466..497 CDD:275378 9/42 (21%)
leucine-rich repeat 498..509 CDD:275378 2/10 (20%)
ISLR2NP_001123608.1 leucine-rich repeat 36..52 CDD:275380 7/15 (47%)
LRR_8 52..109 CDD:404697 11/56 (20%)
LRR 1 52..73 7/20 (35%)
leucine-rich repeat 53..76 CDD:275380 7/22 (32%)
LRR 2 76..97 2/20 (10%)
leucine-rich repeat 77..100 CDD:275380 2/22 (9%)
LRR_8 99..159 CDD:404697 13/60 (22%)
LRR 3 100..123 5/23 (22%)
leucine-rich repeat 101..124 CDD:275380 5/23 (22%)
LRR 4 124..145 6/20 (30%)
leucine-rich repeat 125..148 CDD:275380 6/22 (27%)
LRR 5 148..169 4/20 (20%)
leucine-rich repeat 149..172 CDD:275380 4/22 (18%)
PCC 154..>228 CDD:188093 15/63 (24%)
Ig_3 232..359 CDD:404760
Ig strand B 256..263 CDD:409353
Ig strand C 269..274 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..326
Ig strand C' 305..307 CDD:409353
Ig strand D 331..335 CDD:409353
Ig strand E 338..343 CDD:409353
Ig strand F 351..359 CDD:409353
Ig strand G 362..372 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..466
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 656..722
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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