Protein Alignment hfw and swi2

DIOPT Version :10

• Sequence 1: NP_569933.2
• Gene: hfw / 31120
• FlyBaseID: FBgn0001189
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: XP_061506634.1
• Gene: swi2 / 4576500
• VectorBaseID: AGAMI1_007695
• Length: 544
• Species: Anopheles gambiae
• Alignment Length: 566
• Identity: 134/566 - (23%)
• Similarity: 245/566 - (43%)
• Gaps: 117/566 - (20%)

  Fly    67 GTAIPAPI----LTTDNVGIGETTTASSLAETQSMSDPGSVTDTTSTSTSHSTSTTSTTSPAPLP 127
            ||....|:    |..:||.|.|..           |...|.|.::.....||:|::|:::.|.|.
Mosquito    65 GTNSQLPLSLQNLVVENVAIEECA-----------SPARSATHSSQPHAPHSSSSSSSSNTANLH 118

  Fly   128 PAAPEQPEYLKHCFYA--EEQLCGHTFDGRAETSEGQGSTVAQSEAQNRGGQGNSQCQCREHPTR 190
            ...|.       |.:.  ...:|...|    ||...|.           ||:.|
Mosquito   119 SNRPA-------CVFTPPNRTVCYRGF----ETKRFQA-----------GGRFN----------- 150

  Fly   191 PNSWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLS--NPIFRS-----LQSLAVTDGNIT 248
                       ||                |.:.:.|..|.  :|:..:     ::.||:|...:.
Mosquito   151 -----------LT----------------RRLVLCDWPLKSFDPLVLARLVPRIERLAITGRMLQ 188

  Fly   249 RLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLV-PHRNQNKNITLDISG 312
            ||.:.||.|..|:.:||:...::.....|..::..|:...:..|.|..: |:|.::.::.:.:.|
Mosquito   189 RLAHDFPPLPYLRMVNITGTRLNHTGVNAFYELERLQVLNLRGNELEQIQPYRFRSGHVEVYLQG 253

  Fly   313 NMRMLCTPLNEIIY---TESINFLNPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTNCPVIP 374
            |: ..||  |::|:   .:|..:::.....|:     .| :.|.:..:..:| .||.|....:..
Mosquito   254 NL-WNCT--NDMIWLLKEQSRQYVDKPTLVCK-----DW-KYTGRPVLTAME-YKRVVRESCLHE 308

  Fly   375 NYGSCNCTLENIMIIQDNQS-KPQCHVDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTN 438
            ...:|:|.:..:.:..:..| .|...|:||:.|..:|||.||.||.:|::..||:.|: |...||
Mosquito   309 EIWNCSCHVSYLRLSDNGLSFHPMIMVNCSDRGFYQLPQYLPGNTTVLHMARNKLQSV-DSLTTN 372

  Fly   439 PTYHNINRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNAL-MDSGLGRRIYL 502
            ..|.::..:..|.|:|:||...|.|.:::.|:.:.:|.|.:::|..|.:.:|: .:.|:| ::||
Mosquito   373 EHYQSVQDIYLDENRITSIDILEDTIWLDNFRILSLRGNRMNRIRVYSVEHAIERNPGVG-KVYL 436

  Fly   503 AGNKLQCDCNSAKTLQNWLKERSSDIPDYMEIRC--------RNMPQRVIELQEAKLCQSPPDWT 559
            :.|..:|.|..|...|.:|::..|.:.|...|.|        |.....|:.:....:|: |.:..
Mosquito   437 SNNPWRCGCRFAIRFQRFLRKHESLVADSRNITCYFINDDDGRKQYLPVLTVTPNDICR-PSEHN 500

  Fly   560 DYIYY----LIAAEVLLLLALITKVSYDYWVFKTAGYLPWPASKMP 601
            ...:|    :|.|.:::|  :.||::|||:.::..|.|||...|||
Mosquito   501 TAAFYNTLSIIFATLIIL--IFTKLAYDYYHYRKYGKLPWLIMKMP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_569933.2	LRR	<198..>313	CDD:443914	23/122 (19%)
		leucine-rich repeat	237..259	CDD:275378	8/21 (38%)
		leucine-rich repeat	260..283	CDD:275378	4/22 (18%)
		leucine-rich repeat	284..304	CDD:275378	5/20 (25%)
		leucine-rich repeat	420..443	CDD:275378	8/22 (36%)
		leucine-rich repeat	444..465	CDD:275378	7/20 (35%)
		leucine-rich repeat	466..497	CDD:275378	7/31 (23%)
		leucine-rich repeat	498..509	CDD:275378	3/10 (30%)
swi2	XP_061506634.1	None