DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hfw and kek6

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	69/379 - (18%)
Similarity:	118/379 - (31%)	Gaps:	156/379 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLS---NPIFRSLQSLAVTDGNITRLVNAF 254
            :|...:...|:..|:|:  .|||| ..::.....:.|:   |.:...||.|.:.|.:|..|..
  Fly    27 AWTVADDWSLSCASNCT--CKWTN-GKKSAICSSLQLTTIPNTLSTELQVLVLNDNHIPYLNR-- 86

  Fly   255 PRLSALKCLN-----ISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLVPHRNQNKNITLDISGNM 314
            ...|.|..||     :..:.:..||..:.:::..|....:|:|.|.::     :|:..:   ||.
  Fly    87 EEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEML-----DKDTFM---GND 143

  Fly   315 RMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTNCPVIPNYGSC 379
            |:      .|:|...    ||......|                          ..|::|:..:.
  Fly   144 RL------RILYLNG----NPLKRLAAY--------------------------QFPILPHLRTL 172

  Fly   380 ---NCTLENIMIIQDNQSKPQCHVDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTY 441
               :|.:..|    |..|       .:||.|:|          .||:.||.:.||.:|
  Fly   173 DMHDCLISYI----DPMS-------LANLNLLE----------FLNLKNNLLESLSEY------- 209

  Fly   442 HNINRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNK 506
                                      .||  :|.|.....:.|                    |.
  Fly   210 --------------------------VFQ--HMANLKTLSLEE--------------------NP 226

  Fly   507 LQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAKLCQSPPDWTD 560
            .||:|...| .:.|          |:..|..::         :.:|:.||...|
  Fly   227 WQCNCKLRK-FRGW----------YVNSRLSSV---------SLVCKGPPAQKD 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566	15/63 (24%)
		leucine-rich repeat	237..259	CDD:275378	6/21 (29%)
		leucine-rich repeat	260..283	CDD:275378	5/27 (19%)
		leucine-rich repeat	284..304	CDD:275378	4/19 (21%)
		leucine-rich repeat	420..443	CDD:275378	7/22 (32%)
		leucine-rich repeat	444..465	CDD:275378	0/20 (0%)
		leucine-rich repeat	466..497	CDD:275378	5/30 (17%)
		leucine-rich repeat	498..509	CDD:275378	1/10 (10%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	8/26 (31%)
		LRR_8	96..155	CDD:290566	14/76 (18%)
		leucine-rich repeat	97..120	CDD:275380	2/22 (9%)
		leucine-rich repeat	121..144	CDD:275380	7/30 (23%)
		LRR_4	144..186	CDD:289563	11/81 (14%)
		leucine-rich repeat	145..168	CDD:275380	6/58 (10%)
		leucine-rich repeat	169..216	CDD:275380	18/102 (18%)
		LRRCT	225..274	CDD:214507	12/56 (21%)
		Ig	295..367	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100