DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfw and Lrt

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	651	Identity:	140/651 - (21%)
Similarity:	224/651 - (34%)	Gaps:	227/651 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SLAETQSMSDPGSVTDTTSTSTSHSTSTTSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDG 154
            :||....:.|  .:.|:|   ||.||||||:|.|:.:  .:|..|.    .:............|
  Fly    38 TLAAANDLKD--LLEDST---TSSSTSTTSSTIPSSV--TSPTTPT----AYVVSAAAVPALVAG 91

  Fly   155 RAETSEGQGSTVAQSEAQNR------------------------GGQGNSQCQC---REHPTRPN 192
            |.::....|..|.:|..:.|                        .|..|::.:|   ..|..|
  Fly    92 RGKSKSTSGKYVNKSSPRKRKAEQVSSLPLPVDDALMEWKCPNITGTRNAELECGCDLPHTLR-- 154

  Fly   193 SWYCCNISQLTMI-------SSCSNISKWTNLHVRNMT-VEDMDLSNPIFRSLQSLAVTDGNITR 249
                |||....|:       :|..:|| ..:..:||:| :.|..:.:.:  ||..|.::.|.|.|
  Fly   155 ----CNIDLHGMMLLADRLRTSPYSIS-LLDCSLRNVTFLSDAKIFDNV--SLHGLVISSGEIKR 212

  Fly   250 L--------------------------VNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFG 288
            :                          .||...||||:.|:::||.|..:.:.....:..|.:..
  Fly   213 VHKSAFLGIRGPLQALGLPGNALMSVPWNALSTLSALERLDLANNKIKALGTADFVGLTSLVYLE 277

  Fly   289 MSNNNLSLVPHR---NQNKNITLDISGNMRMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQ 350
            :|||.:|.:..|   |..|...|.:.||.      |.:  |.:|:..|    |.|
  Fly   278 LSNNQISSISQRTFVNLRKLEVLKLGGNR------LGD--YAQSLRSL----SQC---------- 320

  Fly   351 STDKVSVEQLE------NRKRCVTNCPVIPNYGSCNCTLENIMIIQD----------------NQ 393
                :|:.||:      |........|.:.|..|.|.....|..||:                ||
  Fly   321 ----LSLRQLDLQANNLNGPLSEQTLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRHNQ 381

  Fly   394 -SKPQCH----------VDCSNLGLVELP----QRLPDNTFMLNITNNKITSL-GDYFHTNPTYH 442
             ...|.|          :|.|..|:|.:.    |.|...| :|::|:|.:.:| .|.....|:..
  Fly   382 IDVLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLT-VLDLTHNFLRALTSDLIAPLPSLR 445

  Fly   443 NINRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNKL 507
            .: ||..::..|.:....:|.:.:|:.|   |:.|.||
  Fly   446 EL-RLAGNDISIVARNAMDGARELESLQ---MQENPLS--------------------------- 479

  Fly   508 QCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAKLCQSP----------------- 555
             ||| |.:....||:|  |.:...:...|...|:    |:.|.|.|.|
  Fly   480 -CDC-SIRPFAEWLQE--SQLHSSLSASCVTPPR----LEGAPLLQVPVETLSCDMDNVEKDNAN 536

  Fly   556 ----------PDWTDYIYYLIAAEVLLLLALITKVSYDYWVFKTAGYLPWPASKMPKLPCDWLCE 610
                      |:.|..|..|  :|.::|..|  ..|.||.:.     |.|..:...|   |::|:
  Fly   537 IMQHLETLAKPNQTSPIKDL--SEEIILHEL--HFSTDYGLI-----LTWLLNLSKK---DYMCD 589

  Fly   611 S 611
            :
  Fly   590 A 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566	20/84 (24%)
		leucine-rich repeat	237..259	CDD:275378	8/47 (17%)
		leucine-rich repeat	260..283	CDD:275378	5/22 (23%)
		leucine-rich repeat	284..304	CDD:275378	7/22 (32%)
		leucine-rich repeat	420..443	CDD:275378	6/23 (26%)
		leucine-rich repeat	444..465	CDD:275378	4/20 (20%)
		leucine-rich repeat	466..497	CDD:275378	6/30 (20%)
		leucine-rich repeat	498..509	CDD:275378	0/10 (0%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	49/217 (23%)
		leucine-rich repeat	179..199	CDD:275378	4/21 (19%)
		leucine-rich repeat	200..223	CDD:275380	5/22 (23%)
		leucine-rich repeat	225..248	CDD:275380	3/22 (14%)
		LRR_8	249..307	CDD:290566	16/63 (25%)
		leucine-rich repeat	249..272	CDD:275380	5/22 (23%)
		LRR_RI	<270..479	CDD:238064	53/239 (22%)
		leucine-rich repeat	273..296	CDD:275380	7/22 (32%)
		leucine-rich repeat	297..322	CDD:275380	9/50 (18%)
		LRR_8	322..382	CDD:290566	12/59 (20%)
		leucine-rich repeat	323..347	CDD:275380	4/23 (17%)
		leucine-rich repeat	348..371	CDD:275380	5/22 (23%)
		LRR_8	370..428	CDD:290566	13/58 (22%)
		leucine-rich repeat	372..395	CDD:275380	4/22 (18%)
		leucine-rich repeat	396..419	CDD:275380	6/22 (27%)
		LRR_8	418..478	CDD:290566	15/64 (23%)
		leucine-rich repeat	420..443	CDD:275380	6/23 (26%)
		leucine-rich repeat	444..467	CDD:275380	4/23 (17%)
		LRRCT	476..526	CDD:214507	18/84 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100