DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfw and swi2

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_611247.3	Gene:	swi2 / 37010	FlyBaseID:	FBgn0034262	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	134/551 - (24%)
Similarity:	217/551 - (39%)	Gaps:	137/551 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 DTTSTSTSHSTSTTSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDGRAETSEGQGSTVAQS 169
            |:..|||..:|.||.||...|:|.:.       :.||            |.:...|..|...::|
  Fly    32 DSHETSTLLATITTITTEIIPMPDSG-------RSCF------------GWSSAPEAAGGNCSRS 77

  Fly   170 EAQNRGGQGNSQCQCREHPTRPNSWYCCNISQLTMISSCSNISKWTNLHVRNMTVEDMDLSNPIF 234
               ||  .|..:|....:          |::.|......|.:.....:.:.....:.::    .|
  Fly    78 ---NR--NGTLKCYGGMN----------NLAALNQSGKLSRVQPALEMLLCGWPKDGLN----HF 123

  Fly   235 RSLQ------SLAVTDGNITRLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNN 293
            |.||      ||.:.....|.....||.:..|..:|||..|:|.|.||..|.|..|:...:..|.
  Fly   124 RDLQKLPRLRSLTIEYSGFTEFKFDFPEMLELHTINISWTNLSYISSRTFKRVHPLKVLDLRWNQ 188

  Fly   294 LSLVPHRNQNKNITLDISGNMRMLCTPLN-EIIYTESINFLNPKHSYCQYNATHT--WFQ----- 350
            |           |.||     ..|..|.| |.:|...    ||      :|.|..  |..
  Fly   189 L-----------IQLD-----GPLLLPRNFEQLYLAG----NP------WNCTRNFKWLLLQPEK 227

  Fly   351 -----------STDKVSVE---------QLENRKRCVTNCPVIPNYGSCNCTLENIMIIQDNQSK 395
                       .||:...|         :||.:::|.::    .:..:|.|.:.:|:
  Fly   228 GRLVVDRDELICTDRKYKERQMLMVMHYKLELKRQCQSH----EDLRNCTCLMHHIL-------- 280

  Fly   396 PQCH-----VDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTYHNINRLLADNNQIS 455
            |:.|     |:||:|....||..|||||..|.|.:|.|:.:.. ...||.|.::..:..:|||||
  Fly   281 PKTHIPLYTVNCSHLQFHRLPDFLPDNTTTLVINDNMISDINP-LRDNPHYRHVVDMQLENNQIS 344

  Fly   456 SIYEFEGTKFIETFQRIYMRNNSLSKIPEYFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNW 520
            ::...|.|.:::.|:.:.:|.|:|.|:..|.|:|||.|:.....:.|:.|...|.|.....::..
  Fly   345 NVDNLEDTYWLQNFRLLNLRGNNLRKLHVYALDNALDDNENANLLLLSRNPWHCTCKFGSRMREL 409

  Fly   521 LKERSSDIPDYMEIRCR------NMPQRVIELQEAKLCQ---------SPPDWTDYIYYLIAAEV 570
            |.:....:.|...:.|.      .:..:|:.|...::|.         .|.||.:.:   :|:.:
  Fly   410 LTKYKDIVRDAWNVSCTYRLDDDQLLAKVLTLSRQEMCNLSVEGGTQIHPIDWLNGV---LASLI 471

  Fly   571 LLLLALITKVSYDYWVFKTAGYLPWPASKMP 601
            .|:|.   |::|||:.:|..|.:||...|||
  Fly   472 FLILG---KLAYDYYYYKYYGRVPWIVMKMP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566	21/64 (33%)
		leucine-rich repeat	237..259	CDD:275378	7/27 (26%)
		leucine-rich repeat	260..283	CDD:275378	11/22 (50%)
		leucine-rich repeat	284..304	CDD:275378	3/19 (16%)
		leucine-rich repeat	420..443	CDD:275378	7/22 (32%)
		leucine-rich repeat	444..465	CDD:275378	7/20 (35%)
		leucine-rich repeat	466..497	CDD:275378	11/30 (37%)
		leucine-rich repeat	498..509	CDD:275378	2/10 (20%)
swi2	NP_611247.3	LRR	<117..384	CDD:227223	83/309 (27%)
		leucine-rich repeat	132..154	CDD:275378	5/21 (24%)
		leucine-rich repeat	155..178	CDD:275378	11/22 (50%)
		leucine-rich repeat	179..201	CDD:275378	8/37 (22%)
		leucine-rich repeat	202..214	CDD:275378	4/21 (19%)
		leucine-rich repeat	287..307	CDD:275378	8/19 (42%)
		leucine-rich repeat	308..332	CDD:275378	8/24 (33%)
		leucine-rich repeat	333..357	CDD:275378	7/23 (30%)
		leucine-rich repeat	358..385	CDD:275378	11/26 (42%)
		leucine-rich repeat	386..398	CDD:275378	2/11 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012692
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010