DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfw and ISLR

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_005536.1	Gene:	ISLR / 3671	HGNCID:	6133	Length:	428	Species:	Homo sapiens

Alignment Length:	338	Identity:	75/338 - (22%)
Similarity:	118/338 - (34%)	Gaps:	102/338 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 LQSLAVTDGNI-TRLVNAFPRLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLVP-- 298
            ||||.:....| |....|...||.||.|::|:|.||:.....:.::..|:...|.:|.|:.:|
Human    76 LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELTFIPRD 140

  Fly   299 -----------HRNQNKNITLDISGNMRMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQST 352
                       ..|.|:..|| ..|..    |||..:.:.: || .||....|......||..:|
Human   141 AFRSLRALRSLQLNHNRLHTL-AEGTF----TPLTALSHLQ-IN-ENPFDCTCGIVWLKTWALTT 198

  Fly   353 DKVSVEQLEN---------RKRCVTNCPVIPNYGSCNCTLENIMIIQ------------------ 390
             .||:.:.:|         :...::..|.:|      |:..::.:..
Human   199 -AVSIPEQDNIACTSPHVLKGTPLSRLPPLP------CSAPSVQLSYQPSQDGAELRPGFVLALH 256

  Fly   391 ---DNQSKPQCHVDCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTYHNINRLLADNN 452
               |.|..||.|..      :::|..:      :.||:..:.:.|......|...:..|..|..|
Human   257 CDVDGQPAPQLHWH------IQIPSGI------VEITSPNVGTDGRALPGTPVASSQPRFQAFAN 309

  Fly   453 QISSIYEF----EGTKFIETFQRIY--MRNNSLSKIPEYFLNNALMDSG------LGRRI----- 500
            ....|.:|    |||         |  :..|.|.. .|..::.||...|      ||||.
Human   310 GSLLIPDFGKLEEGT---------YSCLATNELGS-AESSVDVALATPGEGGEDTLGRRFHGKAV 364

  Fly   501 -----YLAGNKLQ 508
                 |...|::|
Human   365 EGKGCYTVDNEVQ 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566	19/57 (33%)
		leucine-rich repeat	237..259	CDD:275378	8/22 (36%)
		leucine-rich repeat	260..283	CDD:275378	7/22 (32%)
		leucine-rich repeat	284..304	CDD:275378	6/32 (19%)
		leucine-rich repeat	420..443	CDD:275378	4/22 (18%)
		leucine-rich repeat	444..465	CDD:275378	8/24 (33%)
		leucine-rich repeat	466..497	CDD:275378	7/38 (18%)
		leucine-rich repeat	498..509	CDD:275378	5/21 (24%)
ISLR	NP_005536.1	leucine-rich repeat	32..51	CDD:275380
		LRR_8	51..110	CDD:316378	14/33 (42%)
		LRR 1	51..72
		leucine-rich repeat	52..75	CDD:275380
		LRR 2	75..96		7/19 (37%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		LRR_8	98..158	CDD:316378	15/59 (25%)
		LRR 3	99..122		7/22 (32%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR 4	123..144		5/20 (25%)
		leucine-rich repeat	124..147	CDD:275380	5/22 (23%)
		LRR 5	147..168		5/25 (20%)
		leucine-rich repeat	148..171	CDD:275380	8/27 (30%)
		PCC	153..>227	CDD:188093	20/81 (25%)
		I-set	239..340	CDD:333254	22/122 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100