DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hfw and haf

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	116/497 - (23%)
Similarity:	186/497 - (37%)	Gaps:	134/497 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 TSTTSPAPLPPAAPEQPEYLKHCFYAEEQLCGHTFDGRAETSEGQGSTVAQSEAQNRGGQGNSQC 182
            |:|..||...|.....|..|.....|..| |    ..:.:..:.|.|.:.   |.|.|.:.:.||
  Fly     6 TTTALPAATTPLLLLLPLILGRLHVAHAQ-C----PWQRDVPDLQTSCIC---AYNLGRELSVQC 62

  Fly   183 QCREHPTRPNSWYCCNISQ-LTMISSCSNISKWTNLHVRNMTVEDMDLSNPIFR--SLQSLAVTD 244
            .            ..:.|| |..:::.:.:.....|:|.|.|:.  :|.:.:|.  ||.:|.::.
  Fly    63 D------------QVDFSQLLAAMNTHARLKPVDLLYVNNSTIS--ELPDAVFSNLSLHNLQLSS 113

  Fly   245 GNITRL-VNAFP-RLSALKCLNISNNNISEIHSRAVKDVPHLEFFGMSNNNLSLVPHR---NQNK 304
            ..|.|: ..||. :.|.|:.||:.:|.::::...|:|.:..|....:|.|.||.:|..   ...|
  Fly   114 CGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSHIPDDAFVGLTK 178

  Fly   305 NITLDISGNMRMLCTPLNEIIYTESINFLNPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTN 369
            ..||.::.|...|.:                       ||.....||...::::..:.||
  Fly   179 LSTLKLNDNNVTLAS-----------------------NAFRGLEQSLKNLNLKGTKQRK----- 215

  Fly   370 CPVIPNYGSCNCTLENIMIIQDNQSKPQCHVDCSNLGLVELPQRLPDNTF-------MLNITNNK 427
               :|         |:|..:     |....:|.|..|:.|||.......|       .||:..|.
  Fly   216 ---VP---------ESIRGL-----KSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNL 263

  Fly   428 ITSLGD--YFHTNPTYHN---INRLLAD------------------NNQISSIYE--FEGTKFIE 467
            |.|:|:  :.....|..:   :|.|||:                  .|.::|:.|  |.|...|.
  Fly   264 IQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAVHSLKELRVLDIGFNLLTSLPEAAFRGNPGIT 328

  Fly   468 TFQRIYMRNNSLSKIPE---YFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNWLKERSSDIP 529
            .   :.:..|.||.:||   ..||..|      |.:.|.|..|.||| ..:.:..|:  |:.|:
  Fly   329 L---LALDGNPLSSVPEGAFAHLNATL------RGLSLGGRFLHCDC-KLRWVAEWI--RNGDL- 380

  Fly   530 DYMEIRCRNMPQRVIELQEAKLCQSPPDWTDYIYYLIAAEVL 571
             .:..|.|| ||         .|.:||.:.|..:|.|..|.|
  Fly   381 -QVTSRERN-PQ---------FCGTPPRFRDRGFYSIQPEEL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566	17/62 (27%)
		leucine-rich repeat	237..259	CDD:275378	6/23 (26%)
		leucine-rich repeat	260..283	CDD:275378	6/22 (27%)
		leucine-rich repeat	284..304	CDD:275378	6/22 (27%)
		leucine-rich repeat	420..443	CDD:275378	7/24 (29%)
		leucine-rich repeat	444..465	CDD:275378	9/40 (23%)
		leucine-rich repeat	466..497	CDD:275378	9/33 (27%)
		leucine-rich repeat	498..509	CDD:275378	4/10 (40%)
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	55/258 (21%)
		leucine-rich repeat	86..105	CDD:275380	6/20 (30%)
		leucine-rich repeat	106..129	CDD:275380	6/22 (27%)
		LRR_8	131..189	CDD:338972	16/57 (28%)
		leucine-rich repeat	131..154	CDD:275380	6/22 (27%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..202	CDD:275380	6/45 (13%)
		leucine-rich repeat	203..225	CDD:275380	5/43 (12%)
		leucine-rich repeat	226..253	CDD:275380	7/26 (27%)
		LRR_8	254..337	CDD:338972	18/85 (21%)
		leucine-rich repeat	254..302	CDD:275380	11/47 (23%)
		leucine-rich repeat	303..326	CDD:275380	5/22 (23%)
		leucine-rich repeat	327..350	CDD:275380	7/25 (28%)
		PCC	332..>413	CDD:188093	31/101 (31%)
		PRK10927	<1061..>1097	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100