DRSC/TRiP Functional Genomics Resources

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Protein Alignment hfw and Islr2

DIOPT Version :9

Sequence 1:NP_001259135.1 Gene:hfw / 31120 FlyBaseID:FBgn0001189 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_001155007.1 Gene:Islr2 / 320563 MGIID:2444277 Length:789 Species:Mus musculus


Alignment Length:247 Identity:50/247 - (20%)
Similarity:73/247 - (29%) Gaps:94/247 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   401 DCSNLGLVELPQRLPDNTFMLNITNNKITSLGDYFHTNPTY-------HN--------------- 443
            ||:...|.|:|:.||.|...|:::.||||.|......|.|.       |:               
Mouse    80 DCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQ 144

  Fly   444 INRLLADNNQISSIYEFEGTKFIETFQRIYMRNNSLSKIPEYFL------------NNALMDSGL 496
            :..|...:|.||: :.:...:.:...|.:.|.:|.|..:|...|            ||.|.....
Mouse   145 LKNLDLSHNLISN-FPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLEP 208

  Fly   497 G--------RRIYLAGNKLQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAKLCQ 553
            |        ..:.|..|...|.|... .||.|.......:|:...|.|.:.|    |||..    
Mouse   209 GTFDALSALSHLQLYHNPFHCSCGLV-WLQAWAASTRVSLPEPDSIACASPP----ELQGV---- 264

  Fly   554 SPPDWTDYIYYLIAAEVLLLLALITKVSYDYWVFKTAGYLPWPASKMPKLPC 605
                                                      |..::|.|||
Mouse   265 ------------------------------------------PVHRLPALPC 274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hfwNP_001259135.1 LRR_8 235..294 CDD:290566
leucine-rich repeat 237..259 CDD:275378
leucine-rich repeat 260..283 CDD:275378
leucine-rich repeat 284..304 CDD:275378
leucine-rich repeat 420..443 CDD:275378 8/29 (28%)
leucine-rich repeat 444..465 CDD:275378 4/20 (20%)
leucine-rich repeat 466..497 CDD:275378 9/42 (21%)
leucine-rich repeat 498..509 CDD:275378 2/10 (20%)
Islr2NP_001155007.1 leucine-rich repeat 80..96 CDD:275380 7/15 (47%)
LRR_8 96..155 CDD:290566 12/58 (21%)
leucine-rich repeat 97..120 CDD:275380 7/22 (32%)
leucine-rich repeat 121..144 CDD:275380 1/22 (5%)
LRR_4 144..183 CDD:289563 8/39 (21%)
leucine-rich repeat 145..168 CDD:275380 4/23 (17%)
LRR_8 164..227 CDD:290566 12/62 (19%)
LRR_4 169..208 CDD:289563 9/38 (24%)
leucine-rich repeat 169..192 CDD:275380 6/22 (27%)
leucine-rich repeat 193..216 CDD:275380 4/22 (18%)
LRRCT 225..273 CDD:214507 15/98 (15%)
Ig_2 288..417 CDD:290606
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24366
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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