DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hfw and Lrrc52

DIOPT Version :9

Sequence 1:	NP_001259135.1	Gene:	hfw / 31120	FlyBaseID:	FBgn0001189	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001070902.1	Gene:	Lrrc52 / 289199	RGDID:	1312014	Length:	314	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	67/302 - (22%)
Similarity:	106/302 - (35%)	Gaps:	109/302 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 LENRKRCVTNCPVIPNYGSCNCTLENIMIIQDNQSKPQCHVDCSNLGLVELPQRLPDNTFMLNIT 424
            |.:..:|..||                 :.||.:      |.|::|.|.|.|..:|.||..|.:.
  Rat    20 LVSGSKCPNNC-----------------LCQDQE------VACTDLQLTEYPTDIPLNTRRLYLN 61

  Fly   425 NNKITSLGDY---FHTNPTYHNINRLLADNNQISSIYEFEGTKFIETFQRIY--MRNNSLSKIPE 484
            |||||||...   |.::..|     |...||:|..:.::   .||..|:.:|  :.:|:|:.|..
  Rat    62 NNKITSLPALQLGFLSDLVY-----LDCQNNRIREVMDY---TFIGIFKLLYLDLSSNNLTSISP 118

  Fly   485 Y--------------------------FLNNA------LMDSGLG-------------RRIYLAG 504
            :                          |.|..      |.::|:.             :.:||:|
  Rat   119 FSFSILTNLVRLNISNNPHLLYLDKYIFANTTSLRYLDLRNTGMQIIDHTGFHHLVVLQTLYLSG 183

  Fly   505 NKLQCDCNSAKTLQNWLKERSSDIPDYMEIRCRNMPQRVIELQEAK-------------LCQSPP 556
            |..:|:|:......:.|... .|.||.....|...|       |.|             :|.:..
  Rat   184 NPWKCNCSFLDFTIHLLVSH-MDHPDAQNATCTEPP-------ELKGWPITKVGNPLQYMCITHL 240

  Fly   557 DWTDYIYYLI-------AAEVLLLLALITKVSYDYWVFKTAG 591
            |..|||:.|:       |..|...|..:..|.|...:.|::|
  Rat   241 DHQDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNALRKSSG 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_001259135.1	LRR_8	235..294	CDD:290566
		leucine-rich repeat	237..259	CDD:275378
		leucine-rich repeat	260..283	CDD:275378
		leucine-rich repeat	284..304	CDD:275378
		leucine-rich repeat	420..443	CDD:275378	10/25 (40%)
		leucine-rich repeat	444..465	CDD:275378	4/20 (20%)
		leucine-rich repeat	466..497	CDD:275378	10/64 (16%)
		leucine-rich repeat	498..509	CDD:275378	4/10 (40%)
Lrrc52	NP_001070902.1	LRRNT	26..55	CDD:214470	12/51 (24%)
		leucine-rich repeat	35..54	CDD:275380	7/24 (29%)
		LRR_4	56..92	CDD:289563	14/40 (35%)
		leucine-rich repeat	56..78	CDD:275380	9/21 (43%)
		LRR_8	79..136	CDD:290566	12/64 (19%)
		leucine-rich repeat	79..102	CDD:275380	7/30 (23%)
		LRR_4	102..>136	CDD:289563	4/33 (12%)
		leucine-rich repeat	103..126	CDD:275380	4/22 (18%)
		LRR_8	125..185	CDD:290566	7/59 (12%)
		leucine-rich repeat	127..151	CDD:275380	2/23 (9%)
		leucine-rich repeat	152..175	CDD:275380	2/22 (9%)
		TPKR_C2	184..>222	CDD:301599	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1526
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910