Protein Alignment hfw and LRRC17

DIOPT Version :10

• Sequence 1: NP_569933.2
• Gene: hfw / 31120
• FlyBaseID: FBgn0001189
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001026862.1
• Gene: LRRC17 / 10234
• HGNCID: 16895
• Length: 441
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 97/434 - (22%)
• Similarity: 152/434 - (35%)
• Gaps: 135/434 - (31%)

  Fly   147 LCGHTFDGRAETSEGQGSTVAQSEAQNR--GGQGNSQCQCREHPTRPNSWYCCNISQLTMISSCS 209
            ||   |...||..:....:|.......|  ||:..|....|..|..|     |::
Human    10 LC---FCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLP-----CDV---------- 56

  Fly   210 NISKWTNLHVRNMTVEDMDLSNPIF------RSLQSLAVTDGNITRLV-NAFPRLSALKCLNISN 267
                :|.||.:.:..::..|   ::      :.|..:.:....|..|. |.|.:...||.|::..
Human    57 ----YTYLHEKYLDCQERKL---VYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQ 114

  Fly   268 NNISEIHSRAVKDVPHLEFFGMSNNNLSLVPHRNQNKNITLDISGNMRMLCTPLNEIIYTESINF 332
            |.||:|.|.|        |||::.....|:.| ||.|.:|.::             .|||..:::
Human   115 NEISKIESEA--------FFGLNKLTTLLLQH-NQIKVLTEEV-------------FIYTPLLSY 157

  Fly   333 L----NPKHSYCQYNATHTWFQSTDKVSVEQLENRKRCVTNCPVIPNYGSCNCTLE----NIMII 389
            |    ||.|..|:....         :|:.|:...:.       :.||..|....|    .:..|
Human   158 LRLYDNPWHCTCEIETL---------ISMLQIPRNRN-------LGNYAKCESPQEQKNKKLRQI 206

  Fly   390 QDNQ-----------SKPQ----------------CH--------VDCSNLGLVELPQRLPDNTF 419
            :..|           .|||                ||        :||....|.::|..:|.:..
Human   207 KSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIV 271

  Fly   420 MLNITNNKITSLGDYFHTNP----TYHNINRLLADNNQISSI--YEFEGTKFIETFQRIYMRNNS 478
            .|:::.|||..|      .|    ..|.:.:|...:|.|..|  ..|.|...:|   .:.:.|||
Human   272 KLDLSYNKINQL------RPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLE---ELDLSNNS 327

  Fly   479 LSKIPEYFLNNALMDSGLGRRIYLAGNKLQCDCNSAKTLQNWLK 522
            |    :.|....|.|....:.::|..|..:||.| ...|..|||
Human   328 L----QNFDYGVLEDLYFLKLLWLRDNPWRCDYN-IHYLYYWLK 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hfw	NP_569933.2	LRR	<198..>313	CDD:443914	27/121 (22%)
		leucine-rich repeat	237..259	CDD:275378	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275378	9/22 (41%)
		leucine-rich repeat	284..304	CDD:275378	7/19 (37%)
		leucine-rich repeat	420..443	CDD:275378	6/26 (23%)
		leucine-rich repeat	444..465	CDD:275378	6/22 (27%)
		leucine-rich repeat	466..497	CDD:275378	8/30 (27%)
		leucine-rich repeat	498..509	CDD:275378	2/10 (20%)
LRRC17	NP_001026862.1	leucine-rich repeat	63..81	CDD:275380	1/20 (5%)
		LRR 1	82..103		5/20 (25%)
		leucine-rich repeat	84..106	CDD:275380	4/21 (19%)
		LRR	<98..>351	CDD:443914	68/303 (22%)
		LRR 2	106..127		10/28 (36%)
		leucine-rich repeat	107..130	CDD:275380	12/30 (40%)
		LRR 3	130..151		6/34 (18%)
		leucine-rich repeat	131..154	CDD:275380	9/36 (25%)
		leucine-rich repeat	155..244	CDD:275380	17/104 (16%)
		leucine-rich repeat	249..269	CDD:275380	5/19 (26%)
		LRR 4	269..290		6/26 (23%)
		leucine-rich repeat	270..293	CDD:275380	6/28 (21%)
		LRR_8	272..328	CDD:404697	16/64 (25%)
		LRR 5	293..314		5/20 (25%)
		leucine-rich repeat	294..317	CDD:275380	6/22 (27%)
		LRR 6	317..340		8/29 (28%)
		leucine-rich repeat	318..341	CDD:275380	8/29 (28%)