DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dor and AT1G12470

DIOPT Version :9

Sequence 1:	NP_477286.2	Gene:	dor / 31118	FlyBaseID:	FBgn0000482	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_172709.2	Gene:	AT1G12470 / 837804	AraportID:	AT1G12470	Length:	988	Species:	Arabidopsis thaliana

Alignment Length:	1040	Identity:	283/1040 - (27%)
Similarity:	475/1040 - (45%)	Gaps:	198/1040 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DLMHLAVSRNWLVCLLGTPERTTLLRFFLPRAIPPGEAVLEKYLSGSG--------------YKI 111
            |::.|..|:.|::                            :|..|.|              ..|
plant    32 DVIVLGTSKGWII----------------------------RYDFGVGSSNDIDLAVGRTGEQSI 68

  Fly   112 TRMFLDPTGHHIIIALVPKSATAGV-SPDFLYIHCLESPQAQQLKVRRIEKFKDHEITAVAFNPY 175
            .::|:||.|.|.|      :...|| ..:..|.|      |:.||.|.:.:.|...:.|||:|..
plant    69 HKVFVDPGGSHCI------ATVTGVGGAETFYTH------AKWLKPRVLSRLKGLLVNAVAWNRQ 121

  Fly   176 HGNESSTGPILLGTSRGLIFETELNPAADGHVQRKQLYDLGLGRPKYPITGLKLLRVPNSSRYII 240
            ...|.||..|:|||..|.:||..::.........|.|::|......:....::...:.:..||.:
plant   122 QITEVSTKEIILGTQDGQLFEMAVDEKDKREKYIKFLFELEELPEAFKALQMETANISSGMRYYV 186

  Fly   241 VVTSPECIYTFQETLKAEERSLQAIFAGYVSGVQEPHCEERKTDLTFSQLRFFAPPNSKYPKQWA 305
            :..:|..:|:|...     .:|:::||.|..  :..|..|...::..|:|.||.  ..:....:|
plant   187 MAVTPTRLYSFTGI-----GTLESVFASYKE--RAVHFMELPGEIPNSELHFFI--KQRRAVHFA 242

  Fly   306 WLCGEGIRVGELSIEA-----NSAATLIGNTLINLDFEKTMHLSYGERRLNTPKAFVLTEYHAVL 365
            ||.|.||..|.|:..|     |.....:.|..: ||:.|   ||.|...:. |.:..|:|||.:|
plant   243 WLSGTGIYHGGLNFGAQHSYPNGDENFVENKAL-LDYSK---LSDGTEAVK-PGSMALSEYHFLL 302

  Fly   366 LYADHVRAICLLNQEQVYQEAFDEARVGKPLSIERDELTGSI------------YVYTVKTVFNL 418
            |..:.|:.:..::::.:.:..||         |..|.::..|            |.|...::|.:
plant   303 LIGNKVKVVNRISEQIIEELQFD---------ITSDSVSRGIIGLCSDASANVFYAYDQNSIFQV 358

  Fly   419 RVTREERNVWRIYLDKGQYELATAHAAEDPEHLQLVLCQRADAAFADGSYQVAADYYAETDK--S 481
            .|..|.|::|::|||...|..|.|:..:..:..|:.|.| |::||.|..|..||.:||:.:.  |
plant   359 SVIDEGRDMWKVYLDLKVYAAALANCRDPLQRDQVYLVQ-AESAFTDKEYLRAASFYAKINYVIS 422

  Fly   482 FEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMNIIKALVIWLIDLYLIQIN--- 543
            ||||.|||:.:.:...:..::..:|          |.|.:|....|..:..|..:|||.:||
plant   423 FEEVTLKFISINEPEALRTFLLHKL----------DNLSKDDKCQITMISTWATELYLDKINRLL 477

  Fly   544 ------MPDKDEEWRSSWQTEYDEFMMEAHVLSCTRQ-NRETVRQLIAEHADPRNMAQFAIAIGD 601
                  :.::|.|:.|..| |:..||.:     |..: :..|..:::..:.....:..||.....
plant   478 LEDDTAIENRDSEYHSVIQ-EFRAFMSD-----CKDELDEATTVKILESYGRVEELVYFANLKEQ 536

  Fly   602 YDEVV---AQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDALMAQGSRLEVEKLV 663
            |:.||   .||.:|:...|.||.  :..:.||.|::|||||......||::.|| ...|...:|:
plant   537 YEIVVLHYIQQGEAKKALEVLQK--SSVSVELQYQFAPELIMLDAYETVESWMA-NKNLNPRRLI 598

  Fly   664 PTLIIMEN----REQREQTQRYLEFAIYKLNTTNDAIHNFLLHLYAEHEPK-LLMKYLEI---QG 720
            ..::...:    :.:..:..:||||.:::|:..:..||:.||.|||:.|.. .|:::|:.   :|
plant   599 TAMMRYSSGPHAKNETHEVIKYLEFCVHRLHNEDPGIHSLLLSLYAKQEDDGALLRFLQCKFGKG 663

  Fly   721 RDES-LVHYDIYYAHKVCTDLDVKEAR----VFLECMLRKWISAVDLALTFDMKLAKETASRPSD 780
            |:.. ...||..||.::|    :||.|    |.:..|:.....||.|||..|.:||...|.:..|
plant   664 RENGPEFFYDPKYALRLC----LKERRTRACVHIYSMMSMHEEAVALALQIDPELAMAEADKVED 724

  Fly   781 SK-IRRKLWLRIAYHDIK-----GTNDVKKALNLLKECD-LLRIEDLLPFFADFEKIDNFKEAIC 838
            .: :|:||||.:|.|.:|     ...:::||:..|||.| ||:|||:||||.||..||:||||||
plant   725 DEDLRKKLWLMVAKHVVKQEKGAKRENIRKAIAFLKETDGLLKIEDILPFFPDFALIDDFKEAIC 789

  Fly   839 DALRDYNQRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDTCEICEMMLL---------- 893
            .:|.|||::|::|:.||.:.|...|.:..::..|.|....::..:.|.:|:..:|
plant   790 SSLEDYNKQIEQLKEEMNDATRGADNIRNDISALTQRYAVIDRDEECGVCKRKILMMSGDFRMAQ 854

  Fly   894 -------VKPFFIFICGHKFHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEVQTQAQPQSGALSK 951
                   :.||::|.|||.||:.||..||.....:||...:..|::||.            .|..
plant   855 GYSSAGPLAPFYVFPCGHSFHAQCLITHVTSCAHEEQAEHILDLQKQLT------------LLGS 907

  Fly   952 QQAMELQRKRA-----------ALKTEIEDILAADCLFCG-LLISTIDQPFV--DDWEQVNVEWE 1002
            :...::...|:           .|::|::|.:|::|.||| |:|:.|..||:  :| .|.:..|:
plant   908 ETRRDINGNRSDEPITSTTTADKLRSELDDAIASECPFCGELMINEITLPFIKPED-SQYSTSWD 971

Fly 1003 1002
plant 972 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:282925	44/169 (26%)
		CLH	650..797	CDD:128594	48/160 (30%)
		Clathrin	654..783	CDD:279031	39/142 (27%)
		Helo_like_N	<828..889	CDD:305236	21/60 (35%)
		RING	884..>914	CDD:238093	13/46 (28%)
AT1G12470	NP_172709.2	Pep3_Vps18	248..402	CDD:310017	43/168 (26%)
		Clathrin	592..739	CDD:330899	45/150 (30%)
		RING-H2_Pep3p_like	834..951	CDD:319376	31/128 (24%)
		RING-H2 finger (C3H2C3-type)	836..946	CDD:319376	27/121 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3918
eggNOG	1	0.900	-	-		E1_KOG2034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13302
Inparanoid	1	1.050	328	1.000	Inparanoid score	I685
OMA	1	1.010	-	-		QHG53523
OrthoDB	1	1.010	-	-		D87842at2759
OrthoFinder	1	1.000	-	-		FOG0005153
OrthoInspector	1	1.000	-	-		oto2863
orthoMCL	1	0.900	-	-		OOG6_102656
Panther	1	1.100	-	-	LDO	PTHR23323
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3676
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840