Protein Alignment dor and Vps18

DIOPT Version :10

• Sequence 1: NP_477286.2
• Gene: dor / 31118
• FlyBaseID: FBgn0000482
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_758473.3
• Gene: Vps18 / 228545
• MGIID: 2443626
• Length: 973
• Species: Mus musculus
• Alignment Length: 1013
• Identity: 350/1013 - (34%)
• Similarity: 536/1013 - (52%)
• Gaps: 94/1013 - (9%)

  Fly    19 SSGATANSYVATASGNPFETDDEDEIFSRHKMVLRVPSNCTGDLMHLAVSRNWLVCLLGTPERTT 83
            |.|...:.||:.      ..:.|..||::.    ||....:..:..|.||.|.|...||   :.|
Mouse    24 SVGIPHSGYVSA------HLEKEVPIFTKQ----RVDFTPSERITSLVVSCNQLCMSLG---KDT 75

  Fly    84 LLRFFLPRAIPPGEAVLEKYLSGSGYKITRMFLDPTGHHIIIALVPKSATAGVSPDFLYIHCLES 148
            |||..|.:|..|....|.:   ....|:.:||||.||.|:::||        .|.:.||::
Mouse    76 LLRIDLGKASEPNRVELGR---KDDAKVHKMFLDHTGSHLLVAL--------SSTEVLYMN---- 125

  Fly   149 PQAQQLKVRRIEKFKDHEITAVAFNPYHGNESSTGPILLGTSRGLIFETELN--------PAADG 205
              ....|.|.:.::|...:.:|.:|...||||||||||:||::|.|||.||:        ||.|
Mouse   126 --RNGQKARPLARWKGQLVESVGWNKAMGNESSTGPILVGTAQGQIFEAELSASEGGLFGPAPD- 187

  Fly   206 HVQRKQLYDLGLGRPKYPITGLKLLRVPNSSRYIIVVTSPECIYTF-----QETLKAEERSLQAI 265
             :..:.||.|.......|:..|:..|.|: .|..::.|:.:.::.|     ::|   |.:....:
Mouse   188 -LYFRPLYVLNEEGGPAPVCSLEAERGPD-GRGFVIATTRQRLFQFIGRAVEDT---EAQGFAGL 247

  Fly   266 FAGYVSGVQEPHCEERKTDLTFSQLRFFAPPNSKYPKQWAWLCGEGIRVGELSIEANSAATLIGN 330
            ||.|..  ..|...|..::|.:|:|.|:.|.....|:.:||:.|:|:..|  |::.....:|:..
Mouse   248 FAAYTD--HPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYG--SLDCGRPDSLLSE 308

  Fly   331 TLINLDFEKTMHLSYGERRLNTPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQEAFDEARVGKP 395
            ..:   :|....:..|   .|.|.|.|||::|.:||.||.|.|:|.|..:.|.::.|.| :.|..
Mouse   309 ERV---WEYPAGVGPG---ANPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFLE-KFGPL 366

  Fly   396 LSIERDELTGSIYVYTVKTVFNLRVTREERNVWRIYLDKGQYELATAHAAEDPEHLQLVLCQRAD 460
            ..:.:|..||.::.||.:.||...|.||.|:|||.|||..:::||..:..|.|:.|..||.:.||
Mouse   367 RHMVKDSSTGHLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPDCLDTVLAREAD 431

  Fly   461 AAFADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPMETDELDEDKMN 525
            ..|....|..:|..||.|...|||:.|||:....:..:..:::::|:.:  ||.|..:
Mouse   432 FCFRQHRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLAGL--KPTERTQ------- 487

  Fly   526 IIKALVIWLIDLYLIQINMPDKDEEWRSSWQTEYDEFMMEAHVLSCTRQ------NRETVRQLIA 584
             ...|..||.:|||.::.....|.:..:.::...:.|..   .||..|.      :|.::.:|:|
Mouse   488 -ATLLTTWLTELYLSRLGALQGDPDALTLYRDTRECFRT---FLSSPRHKEWLFASRASIHELLA 548

  Fly   585 EHADPRNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPELITRLPKPTVDA 649
            .|.|..:|..||:.:.||:.|||...:.|.|.|||..|...|:|:||||::|.||..:|:..|||
Mouse   549 SHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSPILIRHIPRQLVDA 613

  Fly   650 LMAQGSRLEVEKLVPTLIIME---NREQREQTQRYLEFAIYKLNTTNDAIHNFLLHLYAEHEPKL 711
            .:..||||:..:|:|.|:...   ..:|..|..||:||.:..|..|..||||:||.|||..:|..
Mouse   614 WIEMGSRLDARQLIPALVNYSQGGEAQQVSQAIRYMEFCVNVLGETEQAIHNYLLSLYARGQPAS 678

  Fly   712 LMKYLEIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLALTFDMKLAKETAS 776
            |:.|||..|.....||||:.||.::|.:.....|.|.:..:|..:..||||||..|:.|||:.|.
Mouse   679 LLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVLELYEEAVDLALQVDVDLAKQCAD 743

  Fly   777 RP-SDSKIRRKLWLRIAYHDIKGTNDVKKALNLLKECDLLRIEDLLPFFADFEKIDNFKEAICDA 840
            .| .|.::|:||||:||.|.::...||:.|:..|..|.||:|||:||||.||..||:||||||.:
Mouse   744 LPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASCPLLKIEDVLPFFPDFVTIDHFKEAICSS 808

  Fly   841 LRDYNQRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDTCEICEMMLLVKPFFIFICGHK 905
            |:.||..||||||||.|.|....|:..:||:||....|||.||.|..|:..||.:||::|:|||.
Mouse   809 LKAYNHHIQELQREMEEATASAQRIRRDLQELRGRYGTVEPQDKCSTCDFPLLNRPFYLFLCGHM 873

  Fly   906 FHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEVQTQAQPQSGALSKQQ----AMELQRKRAALKT 966
            ||:|||.:.|.|.|...:..||..|:::|.|    ...|..|::..::    |..:...|..||.
Mouse   874 FHADCLLQAVRPGLPAYKQARLEELQRKLGA----APPPTKGSVKAKEAEAGAAAVGPSREQLKA 934

  Fly   967 EIEDILAADCLFCG-LLISTIDQPFVDD--WEQVNVEW 1001
            ::::::||:|::|| |:|.:||:||:|.  :|:.::.|
Mouse   935 DLDELVAAECVYCGELMIRSIDRPFIDPQRYEEEHLSW 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:461557	51/152 (34%)
		Clathrin	650..783	CDD:459884	53/136 (39%)
		RING_Ubox	883..981	CDD:473075	35/102 (34%)
Vps18	NP_758473.3	Pep3_Vps18	291..434	CDD:461557	51/151 (34%)
		Clathrin	615..743	CDD:459884	50/127 (39%)
		CHCR	618..772		63/153 (41%)
		RING-H2_Vps18	851..949	CDD:438350	34/101 (34%)