DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dor and vps18

DIOPT Version :9

Sequence 1:	NP_477286.2	Gene:	dor / 31118	FlyBaseID:	FBgn0000482	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_775352.2	Gene:	vps18 / 100005887	ZFINID:	ZDB-GENE-020419-33	Length:	974	Species:	Danio rerio

Alignment Length:	1027	Identity:	342/1027 - (33%)
Similarity:	568/1027 - (55%)	Gaps:	107/1027 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IEHNSSGATANSYVATASGNPFETDDEDEIFSRHKMVLRVPSNCTGDLMHLAVSRNWLVCLLGTP 79
            |..:|..:|||..:..:.......::|..||::.::....|..    :...:|..|.|...||
Zfish    14 IRQHSRMSTANIGITHSGFVNVRLEEEKPIFTKQRIDFSPPEK----INQFSVCNNQLCMSLG-- 72

  Fly    80 ERTTLLRFFLPRAIPPGEAVLEKYLSGSGYKITRMFLDPTGHHIIIALVPKSATAGVSPDFLYIH 144
             :.||||..|.:...|.:..|.:   ....|:.|:||||||.|::|.|        .:.:.:|::
Zfish    73 -KDTLLRIDLGKPDQPNQIELGR---KDDSKVHRLFLDPTGSHLVICL--------TTNECVYLN 125

  Fly   145 CLESPQAQQLKVRRIEKFKDHEITAVAFNPYHGNESSTGPILLGTSRGLIFETELNPAADGHVQR 209
                  ....|||.:.:::.|.|.::.:|...|:|::|||||:|||:|:|||.|:: |::|.:..
Zfish   126 ------RNTQKVRGLSRWRGHLIESIGWNKLIGSETNTGPILVGTSQGIIFEAEIS-ASEGSLFN 183

  Fly   210 -------KQLYDLGL-GRPKYPITGLKLLRVPNSSRYIIVVTSPECIYTFQETLK--AEERSLQA 264
                   :|::.|.. |:|. |:..|::.| ...::|.|:.|:.:.::.|...|.  :|::...:
Zfish   184 TNPDQYFRQVHYLEEDGKPA-PVCCLEVER-GLETKYFIIATTRKRLFQFVGKLAEGSEQQGFSS 246

  Fly   265 IFAGYVSGVQE--PHCEERKTDLTFSQLRFFAPPNSKYPKQWAWLCGEGIRVGELS-IEANSAAT 326
            |||..    |:  |..:|...::.:|::.|:.......||.:||:.|.|:..|:|. :..:|
Zfish   247 IFAQN----QDLLPSFQEFPVNMGYSEITFYTSKLRSRPKTFAWMMGNGVLYGQLDYVRPDS--- 304

  Fly   327 LIGNTL-------INLDFEKTMHLSYGERRLNTPKAFVLTEYHAVLLYADHVRAICLLNQEQVYQ 384
            |:.:..       |:|:|.|             |.:.|||::|.:||..|.||.||.||.:.|::
Zfish   305 LLSDVQVWEYTQDIDLNFVK-------------PISIVLTQFHFLLLLPDRVRGICTLNGQVVHE 356

  Fly   385 EAFDEARVGKPLSIERDELTGSIYVYTVKTVFNLRVTREERNVWRIYLDKGQYELATAHAAEDPE 449
            :.|.| :.|....:.:|.:||.:::||.|.||...:.:|.|:||::|::..:::||..:..:.||
Zfish   357 DVFPE-KFGTLQKMIKDPITGLVWIYTEKAVFRYHIQKEARDVWQMYMNMNKFDLAKEYCKDRPE 420

  Fly   450 HLQLVLCQRADAAFADGSYQVAADYYAETDKSFEEVCLKFMVLPDKRPIINYVKKRLSRVTTKPM 514
            .|.:||.:.|:..|.:..|..:|..||.|...|||:.|||:....:..:..::.|:|  |..||.
Zfish   421 CLDMVLAKEAEHCFQNKRYLESAKCYALTQNYFEEIALKFIEAKQEEALKEFLIKKL--VNLKPS 483

  Fly   515 ETDELDEDKMNIIKALVIWLIDLYLIQINMPDKDE-------EWRSSWQTEYDEFMMEAHVLSCT 572
            |..:        |..||.||.:|||.::...:.||       |.|..::|    |:.......|.
Zfish   484 EKTQ--------ITLLVTWLTELYLNRLGQLEADEGKQHLFLETREEFRT----FLKSPKHKDCF 536

  Fly   573 RQNRETVRQLIAEHADPRNMAQFAIAIGDYDEVVAQQLKAECYAEALQTLINQRNPELFYKYAPE 637
            ..||.|:..|:|.|.|..||..|::.:.||:.|::...:.:.|:.||..|....:.:||||::|.
Zfish   537 YNNRSTIYDLLASHGDVDNMVYFSVIMQDYERVISHYCQHDDYSAALDVLSKHCDDKLFYKFSPV 601

  Fly   638 LITRLPKPTVDALMAQGSRLEVEKLVPTLI---IMENREQREQTQRYLEFAIYKLNTTNDAIHNF 699
            |:..:||..|||.:..|:||:.:.|:|.|:   .|.:.:|..:|.||:||.:|:|:...:||||:
Zfish   602 LMQHIPKKVVDAWIQMGNRLDPKNLIPALVNYSQMGSMQQINETIRYMEFCVYELDVKEEAIHNY 666

  Fly   700 LLHLYAEHEPKLLMKYLEIQGRDESLVHYDIYYAHKVCTDLDVKEARVFLECMLRKWISAVDLAL 764
            ||.|||:|:|..|:.|||..|...|.:|||:.||.::|::....:|.|.:..::..:..||||||
Zfish   667 LLSLYAKHKPDALLWYLEQAGTHVSDIHYDLKYALRLCSEHGYLQACVLVYKIMELYEEAVDLAL 731

  Fly   765 TFDMKLAKETASRP-SDSKIRRKLWLRIAYHDIKGTNDVKKALNLLKECDLLRIEDLLPFFADFE 828
            ..|:.|||..|..| .|.::|:||||:||.|.::...|||||:|.|..|:||:|||:||||.||.
Zfish   732 KVDVDLAKSCADLPEDDEELRKKLWLKIARHVVQEEKDVKKAMNCLSSCNLLKIEDILPFFPDFV 796

  Fly   829 KIDNFKEAICDALRDYNQRIQELQREMAETTEQTDRVTAELQQLRQHSLTVESQDTCEICEMMLL 893
            .||:||||||.:|.:||:.|:||::||.|.||...|:..::|::|.....||||:.|..|:..||
Zfish   797 TIDHFKEAICSSLEEYNKHIEELKQEMEEATESAKRIREDIQEMRNKYGVVESQEKCATCDFPLL 861

  Fly   894 VKPFFIFICGHKFHSDCLEKHVVPLLTKEQCRRLGTLKQQLEAEVQT------QAQPQSGALSKQ 952
            .:||::|:|||.||.|||.:.|:|.|:..:..:|..|:::|.|..||      ..:..:.:|.|.
Zfish   862 NRPFYLFLCGHMFHYDCLLQEVIPHLSVYKQNKLDELQKKLAATTQTTKARHKPREEDTVSLGKG 926

  Fly   953 QAMELQRKRAALKTEIEDILAADCLFCG-LLISTIDQPFVD--DWEQVNVEW 1001
            |.     .|..:|::|:||:|.:|::|| |:|.:||:||:|  .::|....|
Zfish   927 QG-----SREQIKSDIDDIIACECVYCGELMIKSIDKPFIDPQKFDQEMSSW 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dor	NP_477286.2	Pep3_Vps18	311..464	CDD:282925	48/160 (30%)
		CLH	650..797	CDD:128594	61/150 (41%)
		Clathrin	654..783	CDD:279031	53/132 (40%)
		Helo_like_N	<828..889	CDD:305236	27/60 (45%)
		RING	884..>914	CDD:238093	15/29 (52%)
vps18	NP_775352.2	Pep3_Vps18	291..435	CDD:282925	48/160 (30%)
		CHCR	618..772		63/153 (41%)
		Clathrin	618..743	CDD:279031	50/124 (40%)
		CLH	641..768	CDD:128594	54/126 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..930		5/29 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577907
Domainoid	1	1.000	94	1.000	Domainoid score	I7479
eggNOG	1	0.900	-	-		E1_KOG2034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13302
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1120
OMA	1	1.010	-	-		QHG53523
OrthoDB	1	1.010	-	-		D356334at33208
OrthoFinder	1	1.000	-	-		FOG0005153
OrthoInspector	1	1.000	-	-		oto40240
orthoMCL	1	0.900	-	-		OOG6_102656
Panther	1	1.100	-	-	LDO	PTHR23323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R896
SonicParanoid	1	1.000	-	-		X3676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800