DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ccdc141 and zormin

DIOPT Version :9

Sequence 1:	XP_003749542.2	Gene:	Ccdc141 / 311134	RGDID:	1593250	Length:	1530	Species:	Rattus norvegicus
Sequence 2:	NP_001261317.1	Gene:	zormin / 2769001	FlyBaseID:	FBgn0052311	Length:	3664	Species:	Drosophila melanogaster

Alignment Length:	1866	Identity:	342/1866 - (18%)
Similarity:	664/1866 - (35%)	Gaps:	534/1866 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 TTVSSVAVQAGDSKIVIAVVKCGKWVRLQLAEAQPNLLEIGSSQDETRKLLHDHELLLAKLKALE 78
            ||:.:|.|:.|..::|||:::..:.:.:::.|.:|.:..:|.:.||:.::..:|:..|..|::|.
  Fly    95 TTIGTVVVRCGPIQLVIALLQSPEKIYIKVVELEPKITALGENLDESLRMQREHDETLRNLQSLP 159

  Rat    79 DRVWGLLQEADRTAEANKEQSEVYDAMAQTLGEAWATLVSMLERRRELLGLTSEFFQSALEFAIK 143
            ..:...:|:||:...:.:..||:.:|||.||...|..::::|:.|:.||.|.::|.....:...|
  Fly   160 GPMDEFVQKADKLLASKRISSELVNAMADTLNIIWQDILNLLQDRQHLLILCTQFHDKMTQCFRK 224

  Rat   144 IDQ----AEDFLQNPHEFESAEALQSLLLLHDRHAKELLERSLVLLNKSQQLTDFIEKFK----C 200
            :||    .|:.|..|    ....:|..|....:...::|...:..|....:|...:|:.:    .
  Fly   225 MDQLELACEETLHPP----DVPRVQEFLNRFKQLRIDMLTGVMAALKDGNELLAQLEELEKLETL 285

  Rat   201 DGSPVNSELIQGAQSSCLKIDSLLELLQDRRRQLDKHLQQQRQELSQVLQLCLWDQQESQVSCWF 265
            |..|  ..:.:.|..:..::...||.|.|||..|:...|.::.::.|.|.|.|..::...:....
  Fly   286 DTRP--EHIKRDATRAVHQVQQWLEALHDRRNSLELAWQTRKIQMEQCLALALLGRELVDLEAAL 348

  Rat   266 QKTIRDLQEQ-SLGSSLSDNKELIRKHEDLTIKAKEWDLAMEKLKSQALGILLSKD-------LT 322
            |:...:|... |||.......|::.|:       :||......|:.:||.|..:|:       .|
  Fly   349 QQARMELNTMYSLGECEHTANEMLTKY-------REWKQQALLLRDRALKITRAKEKVQSAGHFT 406

  Rat   323 EK--------------EHLQLSNQKLNRLQEEFGRLMVDRKAWLTMAHDFFTSANEAFDVLGKVE 373
            |:              |||.|.:|               |:.||..:.:||..|.....||.|:|
  Fly   407 EEDACARAYAVLSGCTEHLDLVDQ---------------REHWLHQSREFFAKAEHTVSVLEKLE 456

  Rat   374 DYLKLLKSEGLSLPALAAKHEELHREIKDSTAAALQKGRTLISQVDSCRAQVTGIHETMGRIQKR 438
            ..|..:|....| |...|...::.|::::.|...|:.|..::.:|...:.:..|:...:..::.|
  Fly   457 LELTSVKLPPHS-PESYAMFSKVDRDVRNFTEEPLRLGYGILDEVGRTQPETQGVKRVLDELENR 520

  Rat   439 VDRLSQQCTAHQEFALKKQQLATSVDDYLRKVEMSVQEMRL----VLATTLDVGSSPSESEKILN 499
            ...:...|....|   .:|::..::.::|......:..:|.    .|..::|:|.:..::::.|.
  Fly   521 KVYIQGICANSSE---DQQKVQRALSEFLNHHNELLAWLRASGQHQLQQSVDMGGNLQQAKQFLL 582

  Rat   500 KYLEL--DIQAK-ETAHALEAAAKITTEKNELELNEVALLPFKVKRLEEELSTLSRSVSYRSQVL 561
            ::.||  |::.| |..:.|..:.|:..|  .|...|...:..|.:.|.:....|...|..|...:
  Fly   583 QHHELMQDLEIKGELINLLLESIKVHLE--SLSPQERYDVDSKAESLHKHWIELKDLVLKRVDYV 645

  Rat   562 QTYIAFRKSSEEVEEQLQSLKEFYLTESPWEDEDDAVVTCQSNSAERKWQLFLKKSFL------- 619
            ...|.|.:.:.|:..||.:|:. .|.::|               .|.|.| ||:.::.
  Fly   646 SLLIDFFELANELSSQLDNLQR-QLQQTP---------------DEHKLQ-FLQATWTGIASTFG 693

  Rat   620 -TQDLSLEFLNLISMAKENEILNVKKEMHIVENVMEKQTNGREELSRLRMAWHLKAMEGKPVKER 683
             .:.....|:||..:   :..|..|.....|:..:...:..:.:::.....|.....|.:.|:..
  Fly   694 ELKSRGQRFINLKIV---DPYLETKSSAQAVQETLNDFSKRQVDVTSSLENWTTSIAEKREVEYL 755

  Rat   684 WETFKEKLKKTTHNVKLLHEVLMPVSALDLGGNLQSMSDLRRRWIAMQPQLQQLHEDVQQIMKEW 748
            .|......::|......:...|.||.......:.|.:...|.:...:...:::..:::||.::..
  Fly   756 LEKVMSDNEETVAKSTQVDTQLYPVFTSQSVDSKQLLISTREKLTNVIQDIERAQDEIQQRIQTT 820

  Rat   749 EVLSGQGVPLKEKAEQLKDLIHLHQRQRERIQ-EYEEILYKTVQF-------------------- 792
            ..:..:..|...|.||:.:.:.:.:.:.:.|: :|..::...:||
  Fly   821 LGIQTKDQPSLAKIEQVINNLRMLKAKLDGIKYDYRTLVESVIQFLENIVQLRREIDDYFARQQK 885

  Rat   793 -----------------HQVKEELTHLIKPRELEL-LAQPMELEGSKEV----LMQL-------- 827
                             .|..::...||...||.: ..:.:|..|::|:    :::|
  Fly   886 EPASGADRSIAEHEKFRDQCMDKFRSLITQSELLIDRVRVLEPPGAREIDTDRILKLLENLRLHF 950

  Rat   828 -GRSQGRRAHVDHLHRLALSLGVDIISSVQRPNCSNI--SAKSLQQQLEALELDSRDWSAKAK-- 887
             ..|..|.:.::.|.::          ...|.:..:|  |..|:.|||..:...|.|..|.||
  Fly   951 ESNSSARMSTLERLEKI----------EQFRSDLEDIDRSLDSVSQQLHEINNQSVDSLAAAKTT 1005

  Rat   888 ----EY-EQVLACSLE-------------------------------------YCTTREEINELK 910
                || |:.:.||:.                                     :.|..|....:|
  Fly  1006 SLAFEYFERTIECSMPRQLKSTRHQRRWGQTAHTIELLEKRIEKFTESTSQQLFITNPESERYVK 1070

  Rat   911 ESFKDIKKKFNNLKFNYSKKNEKSRNLKTLQYQ-IQQVE-----------TYADKIQALRKKMEK 963
            :..:.:.:|:.:.| :..|:..||.|..|..:: :::::           :.::|:..||..:|.
  Fly  1071 DELRKLNEKWQSFK-DQVKQKRKSLNQATDFFEVVEKIDAEYREISYFYTSVSNKVPYLRDSVEA 1134

  Rat   964 VNKKISDSVLSYPSNKANTLVEAMEDLKKHVDDFDKVVTDY-----------KMNLDLT---EHL 1014
            .|  :.:.:.:|.:::...|...::...:...|.:||.:.|           |:.:|:.   |.|
  Fly  1135 GN--LVNDIENYVTSREAALRSKLDSASQCAHDMNKVSSLYNDVMNIFQSFIKLKMDINVVQERL 1197

  Rat  1015 QEVIEECNFWYEDASATVVRVGKYSMECQTREAVDILHRQFQKFVTPSVPQQEERIQEVVSLAQR 1079
            ::...:......||.....|    ....:..||.:.|||:.|..:      :.:|.|..:..|||
  Fly  1198 KQEQRQKEQRERDARDQAER----EKAIKEAEAKERLHREEQSRL------ENQRQQAAIEQAQR 1252

  Rat  1080 LYGLEEGQKYAEKIVTRHKEILESITELCGSLVELKEKLMQGDVPKVNSNLEDFHGNSIDLLKEP 1144
            .....| ....|:.|...:..|::|.|........:|:..:.:..::.| |.|......::..:.
  Fly  1253 ELAARE-LALREQAVREEEARLQAIREQATREQLAREQAAREEELRIQS-LRDIARREEEVRLQN 1315

  Rat  1145 GRDEQTTF---SEER------------SEGQAQGADVS--------------------------- 1167
            .|||:|..   .|||            .|.:.|..:::
  Fly  1316 IRDEETRIRREEEERIRRENESRSKREEEARIQREEITRLQTLRDQVDQQRIVTENIRKDIQVNS 1380

  Rat  1168 -------------------------------AINGTRE-------DGLPV----GLRQSFDK--- 1187
                                           .:.||.|       ||:.:    ..:.:|||
  Fly  1381 IFTELRYASPLFTRPLKDAVSREGDRFVFECEVTGTPEPAVEWFKDGISIQTNSDYKTTFDKGIC 1445

  Rat  1188 -----------------------------------EDSAQGLTLPEDTL----SGEDSE------ 1207
                                               |::|:...:|...|    ||:.:|
  Fly  1446 RLVIEETFAADSARFSCRASNLVGTCDTNATLSVRENAAEVQLVPPRILRFLQSGKATEGSSFQF 1510

  Rat  1208 -CISSDDISLPPLPV------------TPE----------------------------------- 1224
             |:    ::..|||.            :|:
  Fly  1511 ACV----VAGVPLPTVQWFKNDKCIDDSPDYVISYNNGEATLKFEEVFLEDDAVYTCSASNPAGI 1571

  Rat  1225 ---------SPLAPSDMEVEEPASSSALALHISGYRMRTGTGGLGKAPESVLPPPTAFTDGYHNK 1280
                     .||.|:::...:...|:|:|......::....||        :|.|..:  ..||.
  Fly  1572 EHCSASLIVEPLEPTELPSFKVPLSNAMARVGQKIKLEAIVGG--------IPRPEVY--WLHNG 1626

  Rat  1281 K--DTFTSHFE---------RPYPQFKAEPLLTSRG-SGEMSTKLHVNVKCPARMPREVHDKALP 1333
            |  ....|.:|         :.||......:|:::. :||..|..:|.||  .|:|.|..|..:
  Fly  1627 KPFQPRDSKYEYGRVTLIIPQAYPNDAGSYVLSAKNLAGEAYTSCNVIVK--GRLPNETSDSEM- 1688

  Rat  1334 PSSQAQEISLGTQEKVHADSNVTKTQDRLHAALDVSPGLSSQSDTSRSHQRQVGPQGDRKNSSAE 1398
                                           |.|:.|               :.|
  Fly  1689 -------------------------------ASDIEP---------------IKP---------- 1697

  Rat  1399 KSVVSLAGQAPHFSRLLSNVTVTEGSPVTLEVEVTGFPEPTLTWFKKGQKLCADGHLQVLHKDTK 1463
                     |.|..  |.:|::.||.||.|:..:.|.|||.:.|:...:.:.....:|:|.:..:
  Fly  1698 ---------AVHLP--LKDVSIFEGKPVRLDCVIVGQPEPEVIWYHNERPVKESADVQLLFQGDR 1751

  Rat  1464 HSVFIPKVCEADAGLYVAQAQNSSGTLSSKAILHVTG-NHGPPITR 1508
            .|:.|.:|.:.|||.|...|.||:|..||...|.||. |...|.||
  Fly  1752 CSLIIQEVYQEDAGHYKVVAINSAGEASSSCELKVTPLNQAEPATR 1797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccdc141	XP_003749542.2	SPEC	132..356	CDD:238103	52/253 (21%)
		SbcC	<219..804	CDD:223496	120/659 (18%)
		SPEC	260..458	CDD:295325	45/219 (21%)
		I-set	1409..1498	CDD:254352	29/88 (33%)
		Ig	1425..1499	CDD:299845	24/73 (33%)
zormin	NP_001261317.1	SPEC	126..332	CDD:238103	50/211 (24%)
		SPEC	<504..641	CDD:295325	25/141 (18%)
		COG1340	960..1298	CDD:224259	64/361 (18%)
		RILP-like	<1190..1315	CDD:304877	26/136 (19%)
		MAP7	1233..1365	CDD:283355	25/139 (18%)
		I-set	1390..1479	CDD:254352	8/88 (9%)
		IGc2	1403..1469	CDD:197706	8/65 (12%)
		I-set	1491..1580	CDD:254352	9/92 (10%)
		IGc2	1504..1570	CDD:197706	6/69 (9%)
		I-set	1589..1675	CDD:254352	19/95 (20%)
		Ig	1605..1675	CDD:299845	16/79 (20%)
		I-set	1702..1786	CDD:254352	28/85 (33%)
		Ig	1713..1786	CDD:299845	24/72 (33%)
		I-set	1811..1902	CDD:254352
		Ig	1828..1892	CDD:143165
		I-set	1927..2015	CDD:254352
		IGc2	1940..2005	CDD:197706
		I-set	2142..2231	CDD:254352
		Ig	2158..2231	CDD:299845
		I-set	2238..2325	CDD:254352
		Ig	2254..2324	CDD:299845
		I-set	3566..3655	CDD:254352
		Ig	3583..3650	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7470
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5532
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.900