DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and HKR1

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_010708.1	Gene:	HKR1 / 852030	SGDID:	S000002828	Length:	1802	Species:	Saccharomyces cerevisiae

Alignment Length:	1512	Identity:	319/1512 - (21%)
Similarity:	567/1512 - (37%)	Gaps:	382/1512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 LNVVVLQTTTLEPSTAYHKYPAYPSYPSYEYSSHHRGKERAAENLELEKEGVPRKLKLSENIVIQ 400
            ||.:...:.....||:|:.  ...|.|||..|:             :...|...|    ||.:..
Yeast    16 LNAIEAYSNDTIYSTSYNN--GIESTPSYSTSA-------------ISSTGSSNK----ENAITS 61

  Fly   401 PETPATAATTREPLNDINKYQYKRYTYGTDKNDVTEAPEIKSPLKGLHLSENIVILPETTTTTTT 465
            .....|.|.                .|| :....|...|.::.....::|       .||||.|:
Yeast    62 SSETTTMAG----------------QYG-ESGSTTIMDEQETGTSSQYIS-------VTTTTQTS 102

  Fly   466 TTKPVVLTCPTISPPDTTPKPSTTTAVTKSTPKISSTEQH-----STTTAKTTTTKRPTTVTEKT 525
            .|...|.....|:.|.::..|:...:.:..: :||.|..|     :.:.:.||:::..::|...|
Yeast   103 DTMSSVKKSTEIATPSSSIVPTPLQSYSDES-QISQTLSHNPKSVAESDSDTTSSESSSSVIIST 166

  Fly   526 SSATEKPR--TTVVTTTTQ--KRSTTTHNTSPDTKTTIRSTTLSPKTTTTPSTTTPSTTTPSTTT 586
            |.::..||  :.::||.:|  |...|...||     :|..||...:..|..|..  |:.|.::|.
Yeast   167 SDSSAVPREISPIITTDSQISKEEGTLAQTS-----SISETTRIAQMVTRVSQI--SSITAASTI 224

  Fly   587 PSTTTPSTTTPSTTTPSTTTTVKVSTHRPRT-TSQKTTTAST-------TTKKTTTSPKTTKTTD 643
            ...::.||.|..:.|.|...:|:......:: .|:..:::||       |..||::||
Yeast   225 DGFSSESTQTDFSNTVSFENSVEEEYAMSKSQLSESYSSSSTVYSGGESTADKTSSSP------- 282

  Fly   644 IPTSTTSKLSTTTQKTTTTTHKFTAATTSTEKPKTTTEKTS---------TVSTTTKKSTESSPK 699
                .||..|:.:|.|:|.|.:.:.......:|.:.|:.||         .:||....|..:.|.
Yeast   283 ----ITSFSSSYSQTTSTETSESSRVAVGVSRPSSITQTTSIDSFSMSEVELSTYYDLSAGNYPD 343

  Fly   700 PTSSTGKPTT--TPKPSTRTTPTTTKVTTTTQI----TTTTPLRSSTETTSTQPPTTTTPQPTTT 758
            ......:|.|  |.:.|:..:...::.:.|..:    ||...:.|:::|..:...|.|.|..:..
Yeast   344 QELIVDRPATSSTAETSSEASQGVSRESNTFAVSSISTTNFIVSSASDTVVSTSSTNTVPYSSVH 408

  Fly   759 TTLTVTPKTSTTTTTTEKPITSSPKPTTTTQKTTSTAP--------NTTKVAITTQKETTPTQST 815
            :|......:||..:::   :.|||..:.:.......||        ::..||::    :|.|.|.
Yeast   409 STFVHATSSSTYISSS---LYSSPSLSASVSSHFGVAPFPSAYISFSSVPVAVS----STYTSSP 466

  Fly   816 STTIFTRKTTTNNPE-PTSTEKPITSTTPKPS------TTTPKTSTVASSTEKTTISSPKPTTEK 873
            |.::.......::|. |.:.....||:...|:      |::|......|||..::.|:|...:..
Yeast   467 SASVVVPSAYASSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISST 531

  Fly   874 STENPT---------TNSVKTSALTSSTQRATSTTSEPTKTTQNITTTTPKPTTLKTSTQEATTS 929
            .|.:|:         |:|....|..|||.  ||:.|.|...:...|::...|..:.::    .||
Yeast   532 YTSSPSAPVAVSSTYTSSPSAPAAISSTY--TSSPSAPVAVSSTYTSSPSAPVAISST----YTS 590

  Fly   930 TQKVSTVTITTKKATESSP--LTTLSTEEPNTTPKPLRTTTPTTTSVTATTRITTT-------TI 985
            :..|.....:|..::.|:|  :::..|..|:.   |:..::..|:|.:|...|::|       .:
Yeast   591 SPSVPVAVSSTYTSSPSAPAAISSTYTSSPSA---PVAVSSTYTSSPSAPAAISSTYTSSPSVPV 652

  Fly   986 SESSTETTSTQKPKSTTPTSTTRTTPKVTTVIVS--TQNPTTTTSKTSTVTITTPNPSPSTQRPT 1048
            :.|||.|:|...|.:.:.|.|  ::|.|...:.|  |.:|:...:.:||.|.:...|...:...|
Yeast   653 AVSSTYTSSPSAPAAISSTYT--SSPSVPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYT 715

  Fly  1049 TTTRQPTSITASTTSIGTTRI---PTTTNPQNSTSSTDLTTVTRPPCPDPDSTSDKNTNTACTQE 1110
            ::...|.:|:::.||..:..:   .|.|:..::.::...|..:.|..|...|::..::.:|
Yeast   716 SSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSAPAAISSTYTSSPSAPVAVSSTYTSSPSA---- 776

  Fly  1111 LQQVNLLELQSPQKQEQFTHTRTHTALTGSRNTLGGQEVPDYMDDAPSSAEAESGQATTAKAPTM 1175
                 |:.|.|       |.|.:...:..|.:|..          |.||....|..|:.|    |
Yeast   777 -----LVVLSS-------TSTSSPYDIVYSPSTFA----------AISSGYTPSPSASVA----M 815

  Fly  1176 STLAAAHLLQKLFHIISTTPPSREHAPTQRPSSQPSSSQRSRGVTIAQMARHNLATSKPFI---- 1236
            |:.:::.....::.:.|:.  ||....|...|..||:|               |.||..:.
Yeast   816 SSTSSSSPYDIVYSLSSSA--SRSSIATYEFSPSPSTS---------------LPTSSTYTYFSS 863

  Fly  1237 AHSLRLSIQQLASTQKRSIPPKTLVTHNTTKEPEDSEYYDS-----------ETSEQYTDE-DNE 1289
            |::...|.::.::|.  :|.|..:  |:|.....|.....|           .||....|| .:.
Yeast   864 AYAFEFSSERYSTTS--TIAPTQI--HSTLSRITDFLLQTSMAIQSIVSQQISTSSTLNDEIHSS 924

  Fly  1290 VLDKTQPRAMSSTTVAAVLPAVPSTTTEREPQKTSSSPSPTKATSSTTTQPIETTTGDLEYDSSG 1354
            .|....|.|.:....:.::.:..::.|  .|:.::...|.....||:|..|.:|...:.|  :||
Yeast   925 ALSVFNPSASNLVETSLIISSTQASIT--SPKNSAKISSLQSQLSSSTKNPYDTANKNTE--TSG 985

  Fly  1355 SSDYVNDANDISSGVVNSLEARKNFLLSLLKQRLTQIERTEAKKP------ATSTSTTTDAPKTS 1413
            .|..|:                 |||.:           :.|.||      ||.|..||.:..:.
Yeast   986 RSTVVS-----------------NFLYT-----------SSAAKPDNEKFSATPTEITTISSSSH 1022

  Fly  1414 SSSTS-PASTTS---------ESTSPVTSSTARSSLTASKHLGPEALSRQKSLTPQSAEYYDEDD 1468
            :.|.| |:|..|         :|:...||....||..:|..|..|.:...||
Yeast  1023 AYSLSIPSSHNSVTGLSHNFVDSSKSATSFGYSSSSISSIKLSKETIPASKS------------- 1074

  Fly  1469 DYMEDEPVGSSDAEKKEHGTVLISEKQAAATAKRHIAPPSAQPLRQAMLNILATRSEENKVDLKT 1533
                                  :|..|...|               :..:.|...|:..|.:.:.
Yeast  1075 ----------------------VSNTQERIT---------------SFTSTLRANSQSEKSEGRN 1102

  Fly  1534 TSDGLQFRRFESSQIPTEGPPNRASIVVAEALSRRLADNVGEHLPGPTVPHTSDAKAISSVSQTT 1598
            :...||     ||.|.:....:..:.|.:::|||:::..:||                 :..:|.
Yeast  1103 SVGSLQ-----SSHISSNPSLSTNTKVDSKSLSRKVSKTMGE-----------------NGEETG 1145

  Fly  1599 IRSRESQTKSSSQTPPSISTE------TPATQAIQNHRTDEATQSTLEIVTQTTPKSAPPATAVP 1657
            :.:.::|.||||:|..|.|..      .|||.|:|       ||::...|......|..|.|..|
Yeast  1146 LTTTKTQYKSSSETSGSYSRSFTKISIGPATTAVQ-------TQASTNSVFTAPALSTYPTTPYP 1203

  Fly  1658 VAVRQEVLSVNSRPWLLAARNQTVHLTPISSIAARAPSNPVSHANRSINPLVSSPEDHSTEKVPQ 1722
                    |.||..||           |.:.|...:.:.|.:   .|.||.:       |..:|.
Yeast  1204 --------SPNSYAWL-----------PTAIIVESSETGPTT---ASFNPSI-------TGSLPN 1239

  Fly  1723 LI---VKVYEPIDLKIV 1736
            .|   |.|.|||:..::
Yeast  1240 AIEPAVAVSEPINHTLI 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696
		CBM_14	150..197	CDD:279884
		CBM_14	221..275	CDD:279884
HKR1	NP_010708.1	PLN02217	<397..506	CDD:215130	22/115 (19%)
HKR1	NP_010708.1	PHA03307	452..>776	CDD:223039	74/338 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000