DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and MUC6

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens

Alignment Length:	1633	Identity:	422/1633 - (25%)
Similarity:	576/1633 - (35%)	Gaps:	482/1633 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 RCDKNRTQPWLFACPAGTIFSPVERKCLPGDQCPSTEISDSGSYIPQNCE-------LKFPECAE 223
            :|....:|.:. .|.:.....|....|: .|.|.    .|||.    :||       .....|.:
Human  1060 KCSVINSQTFA-TCHSKVYHLPYYEACV-RDACG----CDSGG----DCECLCDAVAAYAQACLD 1114

  Fly   224 EGT---FRSPTDCALY---YTCRLQES-GTYLQTR-FKC----------------PGSNSFDLER 264
            :|.   :|:|..|.:|   |....|:. |.|..|: ..|                ||||   :|.
Human  1115 KGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWHYQPCLCPSQPQSVPGSN---IEG 1176

  Fly   265 KLCRPRSEVDCFDFVPG---PVQVPYAPQPYYPPYPAAPPLYEEDDYDTGAREQQ--PALKSEKL 324
              |...|:.:.||...|   |...|..|||  |..|..|        .||:|..|  |...:
Human  1177 --CYNCSQDEYFDHEEGVCVPCMPPTTPQP--PTTPQLP--------TTGSRPTQVWPMTGT--- 1226

  Fly   325 QVAAEGFEKPSLNVVVLQTTTLEPSTAYHKYPAYPSYPSYEYSSHHRGKERAAENLELEKEGVPR 389
                      |..:.:|.:|  .||.:.:..||.|:......::....|..|:..
Human  1227 ----------STTIGLLSST--GPSPSSNHTPASPTQTPLLPATLTSSKPTASSG---------- 1269

  Fly   390 KLKLSENIVIQPETPATAATTREPLNDINKYQYKRYTYGTDKNDVTEAPEIKSPLKGLHLSENIV 454
                      :|..|.||.|                            |:..|.
Human  1270 ----------EPPRPTTAVT----------------------------PQATSG----------- 1285

  Fly   455 ILPETTTTTTTTTKPVV------LTCPTISPPDTTPKPSTT-TAVTKSTPKISST---------E 503
             ||.|.|..:|.|||.|      .|..|.||..|:...||| |.:|..||..|.|         :
Human  1286 -LPPTATLRSTATKPTVTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSGTSPTLPKSTNQ 1349

  Fly   504 QHSTTTAKTTTTKRPT--TVTEKTSSATEKPRTTVVTTTTQKRSTTTHNTSPDTKTTIRS--TTL 564
            :...|||..||..|||  :.|..|:....:|.....|.|||.| |||..|:|.|..|..|  |..
Human  1350 ELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTR-TTTEYTTPQTPHTTHSPPTAG 1413

  Fly   565 SPKTTTTPSTTT---PSTTTPSTTTPSTTTPSTTTPSTT---TPSTTTTVKVSTHRPRTTSQKTT 623
            ||..:|.|.|.|   .:||.|:.:.|.||.|:...|.:|   ||||.|.: ..||....||....
Human  1414 SPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVI-TPTHAQMATSASNH 1477

  Fly   624 TAST------TTKKTTTSPKTTKTTDIPTSTTSKL--STTTQKTTTTTHKFTAAT---------T 671
            :|.|      ||.|.|.|..|.......||.||:.  |.:|.||.|:.|..|::|         |
Human  1478 SAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTST 1542

  Fly   672 STEKPKTTTEKTSTVSTTTKKSTESSP-------------KPTSSTG-------KPTTT-PKPS- 714
            :|..|..|:.:|.|....|..:|.|.|             .|.||||       |.||| |.||
Human  1543 TTITPNPTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSH 1607

  Fly   715 ------TRTTPTTTKVTTTTQITTTTPLRSSTETTST--QPPTTTTPQPTT-----------TTT 760
                  |...|.:|.:.|.:..|..||..:...|:::  ..||.|.|.|||           |.|
Human  1608 PQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTAPTMT 1672

  Fly   761 LTV-----------TPKTSTT----TTTTEKPITSSPKPTTTTQKTTSTA--PNTTKVAITTQKE 808
            ||.           |.||||:    |::|.....:|...|..|...|||.  |.|...:.|:|..
Human  1673 LTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVTTSGTSQSR 1737

  Fly   809 TT-PTQSTSTTIFTRKTTTNNPEPTS--------------TEKPITSTT-------PKPST---- 847
            :: .|..|||::.:..::|::||.||              |..|:..||       |.|.|
Human  1738 SSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAHTTSATSSRLPTPFTTHSP 1802

  Fly   848 ---TTPKTST--VASSTEKTTISSPKPTTEKSTENPTTNSVKTSALTSSTQRATSTTSEPTKTTQ 907
               |||.:||  |.:::.:||.:.|.|:...:|......|..||.:|.||......|.....|:.
Human  1803 PTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVTPSTHTVIIPTHTQMATSA 1867

  Fly   908 NI----TTTTPKPTTLKT--STQEA-----TTSTQKVSTVTITTKKATESSPLTTLSTEEPNTTP 961
            :|    |.|.|.|||:|.  ||..|     |||....|..:.:|.|.:.|.|..|.||..|..||
Human  1868 SIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTSGTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTP 1932

  Fly   962 KPLRTTTPTTTSVTATTRITTTTISESS---TETTSTQKPKSTTPTST----TRTTPKVTTVIVS 1019
            ......||..||....|.:..||.:.||   |..|:...|..::|.|:    |.|:.:.||...:
Human  1933 TSTTNITPKHTSTGTRTPVAHTTSASSSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPT 1997

  Fly  1020 TQNPTTTTS------KTSTVTITTPNPSPSTQRPTTTTRQPTSITASTTSIGTTRIPTTTNPQNS 1078
            ..:|.||..      .||.||     ||..|...||.|:..||.:..:|..||...|||.....|
Human  1998 PSHPQTTLPTHVPPFSTSLVT-----PSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGS 2057

  Fly  1079 TSSTDLTTVTRPPCPDPDSTSDKNTNTACTQELQQVNLLELQSPQKQEQFTHTRTHTALTGSRNT 1143
            |.:....|||                |:.|.:                  ||:...||...|...
Human  2058 THTAPPMTVT----------------TSGTSQ------------------THSSFSTATASSSFI 2088

  Fly  1144 LGGQEVPDYMDDAPSSAEAESGQATTAKAPTMSTLAAAHLLQKLFHIISTTPPSREHAPTQRPSS 1208
            .....:|......|.|:      ..|.:.|.:|:              :|||.|   ...|..||
Human  2089 SSSSWLPQNSSSRPPSS------PITTQLPHLSS--------------ATTPVS---TTNQLSSS 2130

  Fly  1209 -QPSSSQRSRGVTIAQMARHNLATSKPFIAHSLRLSIQQLASTQKRSIPPKTLVTHNTTKEPEDS 1272
             .||.|..|...:....:..:..||.|.:..|.......:.||...|....:|.||.||.....|
Human  2131 FSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTASVSAS 2195

  Fly  1273 EYYDSETSEQYTDEDNEVLDKTQPRAMSST-TVAAVLP----AVPSTTTEREPQKTSSSPSPTKA 1332
            ..:.|..:...|      :..|.|..:||. |::|:||    .|..|.:......|.:.||..:.
Human  2196 PLFPSSPAASTT------IRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIAFPSTPRT 2254

  Fly  1333 TSSTTTQPI---ETTTGDLEYDSSGSSDYVNDANDISSGVVNSLEARKNFLLSLLKQRLTQIERT 1394
            |:||.|.|.   ::||
Human  2255 TASTHTAPAFSSQSTT------------------------------------------------- 2270

  Fly  1395 EAKKPATSTSTTTDAPKTSSSSTSPASTTSESTSPVTSSTARSSLTASKHLGPEALSRQKSL--- 1456
                 :.|||.||..| ||...:..:..|...|||||:.|.|       |.||......:.|
Human  2271 -----SRSTSLTTRVP-TSGFVSLTSGVTGIPTSPVTNLTTR-------HPGPTLSPTTRFLTSS 2322

  Fly  1457 ------TPQSAEYYDEDDDYMEDEPVGS-SDAEKKEHGTVLISEKQAAATAKRHIAPPSAQPLRQ 1514
                  ||.||             ||.| ........|...:.|:|...|.|            .
Human  2323 LTAHGSTPASA-------------PVSSLGTPTPTSPGVCSVREQQEEITFK------------G 2362

  Fly  1515 AMLNILATRSE------------ENKVDLKTTSDGLQFRRFESSQIPTEGP--PNRASIVVAEAL 1565
            .|.|:..||.|            ..:||.:.:.........:..::|...|  |.|..::..:..
Human  2363 CMANVTVTRCEGACISAASFNIITQQVDARCSCCRPLHSYEQQLELPCPDPSTPGRRLVLTLQVF 2427

  Fly  1566 SRRLADNV 1573
            |..:..:|
Human  2428 SHCVCSSV 2435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696
		CBM_14	150..197	CDD:279884	5/30 (17%)
		CBM_14	221..275	CDD:279884	19/77 (25%)
MUC6	NP_005952.2	VWD	40..192	CDD:214566
		C8	228..297	CDD:285899
		TIL	302..357	CDD:280072
		VWC_out	359..>403	CDD:214565
		VWD	386..549	CDD:214566
		C8	588..660	CDD:285899
		TIL	664..721	CDD:280072
		TIL	782..827	CDD:280072
		VWC	829..886	CDD:302663
		VWD	868..1017	CDD:278521
		C8	1057..1127	CDD:285899	16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455		91/338 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626		47/154 (31%)
		1, truncated	1561..1738		52/176 (30%)
		Approximate repeats	1607..1953		101/345 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834		54/191 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983		39/114 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077		17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196		29/128 (23%)
		PHA03255	2188..>2343	CDD:165513	52/235 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278		15/98 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348		7/37 (19%)
		CT	2351..2434	CDD:214482	16/94 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000