DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and CG7248

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_648530.1	Gene:	CG7248 / 39356	FlyBaseID:	FBgn0036229	Length:	796	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	182/949 - (19%)
Similarity:	259/949 - (27%)	Gaps:	387/949 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YYDNVFGVFKSYPGGGFPVRFDYNNRCSRNYIGIKPHPDQQQYYYVCKPDCVIFSKCRGLESFNA 128
            |.:::...|..||         ||  ||.              |..|...|.....|...:.||:
  Fly    61 YCESLSNGFYEYP---------YN--CSA--------------YITCYDSCADLEYCPDGKLFNS 100

  Fly   129 SSGRC---------VQHVPQHRPDHRPPQ--C---QKEGRFPHPHDCKVYYRCDKNRTQPWLFAC 179
            ....|         ....|...|...||:  |   :.....|...:|..:|.|..::::  ::.|
  Fly   101 PLQICDTPGAVDCEPLPYPTPSPTESPPENPCLGTRNNTLLPSAENCNEFYLCVNDQSK--VYRC 163

  Fly   180 PAGTIFSPVERKCLPGDQ--CPSTEISDSGSYIPQNCELKFPEC--AEEGT-FRSPTDCALYYTC 239
            |...:|:|....|...|.  |.....:..........|..|.:|  .|:|| |..|.:|..||.|
  Fly   164 PGEMLFNPDLNICDDKDNVWCYGDRTTPDPLDTTTPAEESFTKCEDQEKGTFFPDPENCQQYYYC 228

  Fly   240 RLQESGTYLQTRFKCPGSNSFDLERKLCRPRSEVDCFDFVPGPVQVPYAPQPYYPPYPAAPPLYE 304
            ...:|.|.|    .||..|.|:.....|.|       |..|
  Fly   229 WGNKSYTIL----PCPVDNWFNPISGNCGP-------DIAP------------------------ 258

  Fly   305 EDDYDTGAREQQPALKSEKLQVAAEGFEKPSLNVVVLQTTTLEPSTAYHKYPAYPSYPSYEYSSH 369
                 ...||..|.             ..|:::  ...:||:.|:
  Fly   259 -----DACRETTPT-------------STPTID--TSSSTTVAPT-------------------- 283

  Fly   370 HRGKERAAENLELEKEGVPRKLKLSENIVIQPETPATAATTREPLNDINKYQYKRYTYGTDKNDV 434
                                               :|..:...|..|               .::
  Fly   284 -----------------------------------STEDSVGNPCAD---------------QEL 298

  Fly   435 TEAPEIKSPLKGLHLSENIVILPETTTTTTTTTKPVVLTCPT---ISP------PDTTPK----- 485
            ..:..|||..:...|..|        ...:||.|     ||:   ..|      |:.:|.
  Fly   299 GASFPIKSDCQSYLLCLN--------NGESTTAK-----CPSNAWFDPKTGDCGPNVSPTACLES 350

  Fly   486 -PSTTTAVTKSTPKISSTEQHSTTTAKTTTT---------KRPTTVTEKTSSATEKPRTTVVTTT 540
             .:||||||...||....:|...|:....|.         ...:||.....::...|:
  Fly   351 FETTTTAVTTQAPKDPCADQELGTSYPLVTNCQQYILCMGNGESTVANCIYNSWFDPQ------- 408

  Fly   541 TQKRSTTTHNTSPDTKTTIRSTTLSPKTTTTPSTTTPSTTTPSTTTPSTTTPS---TTTPSTTTP 602
                   |.|..||         :||........||.|.||.|..|...||||   :|.|:..|.
  Fly   409 -------TGNCGPD---------VSPTACKESGVTTASPTTTSQATSPLTTPSPTWSTLPTANTE 457

  Fly   603 STTTT--------------------------------VKVSTHRPRT-------------TSQKT 622
            .|||.                                |.::.:.|.:             .|...
  Fly   458 ETTTNPPDIVGICSGESDGYYATYPEVCNKYILCASPVPIAFYCPESLFFNEALQRCVEWESSDC 522

  Fly   623 TTASTTTKK---TTTSPKTTKTTDIPTSTTSKLSTTTQKT------TTTTHKFTAATTSTEK--- 675
            :...|||..   ||.||    .|.|.:::|. |:...|:.      .|..:.:......:|:
  Fly   523 SNGETTTSSPGFTTPSP----DTQICSNSTG-LNLPYQENCQWYIYCTDENSYMMGICGSEEYFD 582

  Fly   676 PKT-------TTEKTSTVSTTTKKSTESSPKPTSSTGKPTTTPKPST--------------RTTP 719
            |.|       :.|....:.||       ||..|.||..|||...|||              :..|
  Fly   583 PWTGKCGFGVSPEACREIQTT-------SPTVTDSTEGPTTVITPSTPGSEPDPCDGAPEGKLVP 640

  Fly   720 TTTKVTTTTQITTTTPL----RSSTETTST------------QPPTTTTPQPTTTTTLTVTPKTS 768
            .....:...|.....|:    |...|.::.            ..|.||.| |.|         ..
  Fly   641 YPDDCSKFIQCIQPDPIVYDCREGQEFSAALERCMAPWFANCSIPATTIP-PVT---------IP 695

  Fly   769 TTTTTTEKPITSSPKPTTTTQKTTSTAP---NTTKVAITTQKETTPTQSTSTTIFTRKTTTNNPE 830
            |||||||||   ||......:...|..|   |.:|.                      ....:|.
  Fly   696 TTTTTTEKP---SPNGICADKAEGSLVPYPGNCSKY----------------------IACEDPI 735

  Fly   831 PTSTEKP---------ITSTTPKPSTTTPKTSTVASSTE 860
            |.....|         :|.|.|..:...|....::..||
  Fly   736 PVGYACPEGEEFNPIILTCTDPHLAGCNPSALHISPKTE 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696	9/56 (16%)
		CBM_14	150..197	CDD:279884	9/46 (20%)
		CBM_14	221..275	CDD:279884	19/56 (34%)
CG7248	NP_648530.1	CBM_14	62..113	CDD:279884	14/75 (19%)
		CBM_14	136..182	CDD:279884	10/47 (21%)
		CBM_14	207..261	CDD:279884	21/93 (23%)
		CBM_14	293..347	CDD:279884	14/81 (17%)
		CBM_14	367..421	CDD:279884	12/76 (16%)
		CBM_14	470..522	CDD:279884	3/51 (6%)
		CBM_14	544..597	CDD:279884	8/53 (15%)
		CBM_14	630..678	CDD:279884	5/47 (11%)
		CBM_14	710..758	CDD:279884	9/69 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100