DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and Hcfc1

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_006229655.1	Gene:	Hcfc1 / 363519	RGDID:	1563804	Length:	2091	Species:	Rattus norvegicus

Alignment Length:	1704	Identity:	374/1704 - (21%)
Similarity:	572/1704 - (33%)	Gaps:	462/1704 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 LELEKEGVPRKLKL-----------------SENIVIQ---PETPATAATTREPLNDINKYQYKR 424
            ||.||...|.:::|                 :::.::|   .:.||||||...|
  Rat   359 LETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSP----------- 412

  Fly   425 YTYGTDKNDV---------TEAPEIKSPLKGLHLSENIVILPETTTTTTTTTKPVVLTCPTISPP 480
                 ..|.|         :.||...:|.........|.::|:......:||...||  ||: |.
  Rat   413 -----TPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVL--PTV-PG 469

  Fly   481 DTTPKPSTTTAVTKSTPKISSTEQHSTTTAKTTTTKRPTTVTEKTS-SATEKPRTTVVTTTTQKR 544
            .:...|  |.|.|:..|.:........||.....|.||.:...|.. :.|..|.:..:...||..
  Rat   470 SSISVP--TAARTQGVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSA 532

  Fly   545 STTTHNTSPDTKTTIRSTTLSPKTTTTPSTTTPST-TTPSTTTPSTT---TPSTTTPSTTTPSTT 605
            ..|...::|...........:..|...|.::.|:. :.|:.||...|   ||.|||...|....:
  Rat   533 QGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVAS 597

  Fly   606 TTVKVSTHRPRTTSQKTTTASTTTKKTTTSPKTTKTTDIPTSTTSKLSTTT-----QKTTTTTHK 665
            :.|.||  .|.|...||..|...|..::.:..:|:    |..|..|..|.|     |..||....
  Rat   598 SPVMVS--NPATRMLKTAAAQVGTSVSSAANTSTR----PIITVHKSGTVTVAQQAQVVTTVVGG 656

  Fly   666 FTAATTSTEKPKTT------------------TEKTSTVSTTTKKST--------ESSPKP---- 700
            .|...|..:.|.:.                  |:...|.:.|.:.||        ...|.|
  Rat   657 VTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTI 721

  Fly   701 ----TSSTGKPTTT----------PKPS----TRTTPTTTKVTTTTQITTTTPLRS------STE 741
                ||:.|||||.          .||:    :..:|:|||..||| |..|.|:.:      :|.
  Rat   722 LKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSPSTTKPGTTT-IIKTIPMSAIITQAGATG 785

  Fly   742 TTST----QPPTTTTPQPTTTTT------LTVTPKTST------TTTTTEK-------------- 776
            .||:    .|.|..|.:..|:.|      :|..||.:|      .|....|
  Rat   786 VTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVP 850

  Fly   777 --------PIT-SSPKPTTTTQKTTSTAPNTTKVAITTQKETT----PTQSTSTTIFTRKTTTN- 827
                    |:| |:.||..||.....|...||...:|....|:    ...|||.::.|..||..
  Rat   851 MGGVRLVTPVTVSAVKPAVTTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGT 915

  Fly   828 ---------NPEPTSTEKPITSTTPKPSTTTPKTS--TVASSTEKTTISSP-------------- 867
                     ||...:.....|:.|.....|||..:  .|:..|:.|.|::|
  Rat   916 IATLSSQVINPTAITVSAAQTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVS 980

  Fly   868 ---KPTTEKSTENPT-----TNSVKTSALTSSTQRATSTTSEPTKTTQNITTTT-------PKPT 917
               .||||:.|...|     ...|:...:|.........|.| |.||...|||.       |:||
  Rat   981 ILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHE-TGTTNTATTTVVANLGGHPQPT 1044

  Fly   918 TLK--TSTQEATTS--TQKVSTVTITTKKATESSPLTTLSTEEPNTTPKPLRTTT---------- 968
            .::  ...|||..|  |..|........:...:.|..|..|...||.    .|.|
  Rat  1045 QVQFVCDRQEAAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTA----TTATSNMAGQHGCS 1105

  Fly   969 --PTTTSVTATTRITTTTISESSTETTSTQKPKSTTPTSTTRT-TPKVTTVIVSTQNP------T 1024
              |..|..|.||...||.:|...|......:..:.|||....| .|........|..|      |
  Rat  1106 NPPCETHETGTTSTATTAMSSMGTGQQRDARRATNTPTVVRITVAPGALERAQGTVKPPCQTQQT 1170

  Fly  1025 TTTSKTSTVTIT-----------------TPNPSPS----------------TQRPTTTTRQPTS 1056
            ..||.|.||..|                 |.:.||:                :.:...|.|||.:
  Rat  1171 NMTSTTMTVQATGAPCSAGPLLRPSVALETGSHSPAFVQLALPSVRVGLSGPSSKDVPTGRQPET 1235

  Fly  1057 ITASTTS-------------IGTTR-IPTT-------TNPQNSTSSTDL-------TTVTR---- 1089
            ....||:             :||.| :||:       ::|.::.:.|.|       .|||:
  Rat  1236 YHTYTTNTPTTARSIMVAGELGTARVVPTSQYDCLQASSPSSTMTMTALEALLCPSATVTQVCSN 1300

  Fly  1090 PPCPDPDSTSDKNTNTACTQ---ELQQVNLLELQSPQKQEQFTHTRTHTALTGSRNTLGGQEVPD 1151
            |||   ::.....||||.|.   ..|:|    ..:|..:...|.| ||||.|.:.|  ||...|:
  Rat  1301 PPC---ETHETGTTNTATTSNAGSAQRV----CSNPPCETHETGT-THTATTATSN--GGAGQPE 1355

  Fly  1152 YMDDAPSSAEAESGQATTAKAPTMSTLAAAHLLQKLFHIISTTPPSREHAPTQRPSSQPSSSQRS 1216
            ......|....|:.| ||:...|||....|.:                      |.:.||.....
  Rat  1356 GGQQPASGHPCETHQ-TTSTGTTMSVSVGALI----------------------PDATPSHGTLE 1397

  Fly  1217 RGVTIAQMARHNLATSKPFIAHSLRLSIQQLASTQK-RSIPP----KTLVTHNTT---------K 1267
            .|:.:..:         |.:......::....|||: .|.||    :|..||..|         :
  Rat  1398 SGLEVVAV---------PTVTSQAGATLLASFSTQRVCSNPPCETHETGTTHTATTVTSNMSSNQ 1453

  Fly  1268 EPEDSEYYDSETSEQYTDEDN--------EVLDKTQPRAMSSTTVAAVL--PAVP--STTTEREP 1320
            :|..:.....|.:....|..|        ..:..|.|||:::.|.:..:  |:||  |:.||..|
  Rat  1454 DPPPAASDQGEVASTQGDSTNITSASAITTTVSSTLPRAVTTVTQSTPVPGPSVPNISSLTETTP 1518

  Fly  1321 -QKTSSSPSPTKATSSTTTQPIETTTGDLEYDSSGSSDYVNDAND--ISSGVVNSLEARKNFLLS 1382
             ..||..|.|  ||.:.|.  ..|.|.|:.:   .:.|.:....:  :|.|....|..|:
  Rat  1519 GALTSEVPIP--ATITVTI--ANTETSDMPF---SAVDILQPPEELQVSPGPRQQLPPRQ----- 1571

  Fly  1383 LLKQRLTQIERTEAKKPATSTSTTTDAPKTSSSSTSPASTTSESTSPVTSSTARSSLTASKHLGP 1447
            ||:...|.:....|:..:.|.:....|....||:..|:|....:||.|.::..
  Rat  1572 LLQSASTPLMGESAEVLSASQTPELQAAVDLSSTGDPSSVQEPTTSAVVATVV------------ 1624

  Fly  1448 EALSRQKSLTPQSAEYYDEDDDYMEDEPVGSSDAEKKEHGTVL-----ISEKQAAATAKRHIAPP 1507
                    :.|......:.|...:..|.:..:.|     ||..     ::.::.|.||....|..
  Rat  1625 --------VQPPQPTQSEVDQLSLPQELMAEAQA-----GTTTLMVTGLTPEELAVTAAAEAAAQ 1676

  Fly  1508 SAQPLRQAMLNILATRSEENKVDLKTTSDGLQFRRFESSQIPTEGPPNRASIVVAEALSRRLADN 1572
            :|.......|.|.|......:..:..|.:            |.:.....|::..|| |....|:
  Rat  1677 AAATEEAQALAIQAVLQAAQQAVMAGTGE------------PMDTSEAAAAVTQAE-LGHLSAE- 1727

  Fly  1573 VGEHLPGPTVPHTSDAKAISSVSQTTIRSRESQTKSSSQ-------TPPSISTETPATQAIQNHR 1630
             |:.....|:|.....:.::::.|...:.:|:|.::..|       ..|:.|...|:.::...:.
  Rat  1728 -GQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPADSLNDPSIESNCLNE 1791

  Fly  1631 TDEATQSTLEIVTQTTPKSAPPATAVPVAVRQEVLSVNSRPWLLAARNQTVHLTPISSIAARAPS 1695
            ...|..||:.::..|..:|..|:...   |..:.:.|.|...:.||...|.....|.|:
  Rat  1792 LASAVPSTVALLPSTATESLAPSNTF---VAPQPVVVASPAKMQAAATLTEVANGIESL------ 1847

  Fly  1696 NPVSHANRSINPLVSSPEDHSTEKVPQLIVKVYEPIDLKIVFCPKSCDQDHDHKFDPADNIKTSN 1760
                    .:.|.:..|    ..|.|  |.|..:..|:.::   |.......|.|.|.|:...|:
  Rat  1848 --------GVKPDLPPP----PSKAP--IKKENQWFDVGVI---KGTSVMVTHYFLPPDDAVQSD 1895

  Fly  1761 CTGGCDEEEERIHK 1774
            ...|...:..::.|
  Rat  1896 DDSGTVPDYNQLKK 1909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696
		CBM_14	150..197	CDD:279884
		CBM_14	221..275	CDD:279884
Hcfc1	XP_006229655.1	PLN02153	12..330	CDD:177814
		Kelch_1	32..69	CDD:279660
		KELCH repeat	33..80	CDD:276965
		KELCH repeat	84..134	CDD:276965
		Kelch_3	91..145	CDD:290151
		Kelch_5	134..179	CDD:290565
		KELCH repeat	137..196	CDD:276965
		KELCH repeat	200..253	CDD:276965
		Kelch_3	215..263	CDD:290151
		KELCH repeat	255..319	CDD:276965
		Kelch_3	264..330	CDD:290151
		Kelch_5	319..>351	CDD:290565
		KELCH repeat	322..367	CDD:276965	4/7 (57%)
		FN3	<1912..1941	CDD:238020
		FN3	1947..2052	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000