DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and Muc68E

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	NP_996064.1	Gene:	Muc68E / 2768990	FlyBaseID:	FBgn0053265	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	1713	Identity:	439/1713 - (25%)
Similarity:	661/1713 - (38%)	Gaps:	464/1713 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 KLSENIVIQP-ETPATAATTREPLNDIN-----------------KYQYKRYTYGTDKNDVTEAP 438
            |||...||:. :|....:.|.|.::.:|                 .||.|          :|...
  Fly    60 KLSNQYVIRDGDTQYIKSRTSEKVSQLNLNKNNDTASKLKIGAPYYYQIK----------ITSPT 114

  Fly   439 EIKS-PLK---------GLHLS-ENIVILPETTTTT-----------------------TTTTKP 469
            :||| |::         |:..: |::..:||.|||.                       |||.||
  Fly   115 KIKSLPVEVENDRKDSSGIDTTVEDLTPIPEETTTVAQETTYDPEGSTTREDDTTVAIETTTEKP 179

  Fly   470 VVLTCPTISPPDTTPKPSTTTAVTKST---PKISSTEQHSTTTAKTTTTKRP------------- 518
            ...|  |:.  |:||.|..:|.|.:.|   |:.|:|.:..||.|..|||::|
  Fly   180 EDDT--TVE--DSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIP 240

  Fly   519 ---TTVTEKTS-----SATEKPRTTV-VTTTTQK--RSTTTHNTSPDTKTTIRSTTLSPKTTTTP 572
               |||.::|:     |.|....||| :.|||:|  ..||..:::|..:   .|||::.:||..|
  Fly   241 EESTTVAQETTYDPEGSTTRDDETTVAIETTTEKPEDDTTVEDSTPIPE---ESTTVAQETTYDP 302

  Fly   573 --STTTPSTTTPS--TTTPSTTTPSTTTPSTTTPSTTTTV-KVSTHRPR--TTSQKTTTAS--TT 628
              |||....||.:  |||......:|...||..|..:||| :.:|:.|.  ||.:..||.:  ||
  Fly   303 EGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETT 367

  Fly   629 TKKTTTSPKTTKTTDIPTSTTSKLSTTTQ----KTTTTTHKFTAATTSTEKPK--TTTEKTSTV- 686
            |:|.........:|.||..:|:....||.    .||.......|..|:||||:  ||.|.::.:
  Fly   368 TEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIP 432

  Fly   687 --STTTKKSTESSPKPT------SSTGKPTTTPKPSTRT-----TPTTTKVTTTTQITTTTPLRS 738
              |||..:.|...|:.:      ::....|||.||...|     ||...:.||..|.||..|..|
  Fly   433 EESTTVAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQETTYDPEGS 497

  Fly   739 ST---------ETTSTQPPTTT-----TPQPTTTTTL----TVTPKTSTT---------TTTTEK 776
            :|         |||:.:|...|     ||.|..:||:    |..|:.|||         .|||||
  Fly   498 TTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIETTTEK 562

  Fly   777 P------ITSSPKP---TTTTQKTT------STAPNTTKVAI----------TTQKETTPTQSTS 816
            |      ..|:|.|   ||..|:||      :|..:.|.|||          ||.:::||....|
  Fly   563 PEDDTTAEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEKREDDTTVEDSTPIPEES 627

  Fly   817 TTIFTRKTTTNNPE-------------PTSTEKPITSTTPKPSTTTPKTS-TVASST-------- 859
            ||:  .:.|||:||             .|:||||...||.:.||..|:.| |||..|
  Fly   628 TTV--AQDTTNDPEGSTTREDDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQETTYDPEGST 690

  Fly   860 --EKTTISSPKPTTEKSTENPTTNSVKTSALTSSTQRATSTTSEP-------TKTTQNITTTTPK 915
              |..|..:.:.|||| .|:.||....|.....||..|..||.:|       ..||..|.|||.|
  Fly   691 TREDDTTVAIETTTEK-PEDDTTVEDSTPIPEESTTVAQETTYDPEGSTTREDDTTVAIETTTEK 754

  Fly   916 P---TTLKTST---QEATT-----------STQKVSTVTITTKKATE----------SSPL---- 949
            |   ||.:.||   :|:||           ||.:....|:..:..||          |:|:
  Fly   755 PEDDTTAEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIETTTEKREDDTTVEDSTPIPEET 819

  Fly   950 --------------------TTL----STEEP-------NTTPKPLRTTT----PTTTSVTATTR 979
                                ||:    :||:|       ::||.|..:||    .|.....:|||
  Fly   820 TTVGQETTYDPEGSTTREEDTTVAIETTTEKPEDDTTAEDSTPIPEESTTVAQETTYDPEGSTTR 884

  Fly   980 ITTTTISESSTETTSTQKPKSTTPTSTTRTTPKVTTVIVSTQNP---TTTTSKTSTVTITTPNPS 1041
            ...||:   :.|||:.::...||...:|....:.|||...|.|.   :||..:.:||.|.|
  Fly   885 EDDTTV---AMETTTEKREDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREEDTTVAIET---- 942

  Fly  1042 PSTQRP--TTTTRQPTSITASTTSIGTTRIPTTTNPQNSTSSTDLTTVT------RP-------- 1090
             :|::|  .||....|.|...||::|.   .||.:|:.||:..|.|||.      :|
  Fly   943 -TTEKPEDDTTVEDSTPIPEETTTVGQ---ETTYDPEGSTTREDDTTVAIDTTTEKPEDDTTVED 1003

  Fly  1091 --PCPD------PDSTSDKNTNTACTQELQQVNLLELQSPQKQEQFTHTRTHTALTGSRNTLGGQ 1147
              |.|:      .|:|:|...:|  |:|......:: .:.:|.|..|.....|.:.....|: .|
  Fly  1004 STPIPEESTTVAQDTTNDPEGST--TREDDTTVAID-TTTEKPEDDTTVEDSTPIPEESTTI-AQ 1064

  Fly  1148 EVPDYMDDAPSSAEAESGQA--TTAKAPTMSTLAAAHLLQKLFHIISTTP-PSREHAPTQRPSSQ 1209
            |. .|..:..::.|.::..|  ||.:.|...|.           :..:|| |.......|..::.
  Fly  1065 ET-TYDPEGSTTREDDTTVAIETTTEKPEDDTT-----------VEDSTPIPEESTTVAQDTTND 1117

  Fly  1210 P-SSSQRSRGVTIAQMARHNLATSKPFIAHSLRLSIQQLASTQKRSIP---PKTLVTHNTTKEPE 1270
            | .|:.|....|:|    .:..|.||           :..:|.:.|.|   ..|.|..:||.:||
  Fly  1118 PEGSTTREDDTTVA----IDTTTEKP-----------EDDTTVEDSTPIPEESTTVAQDTTNDPE 1167

  Fly  1271 DSEYYDSETSEQYTDEDNEVLDKTQPRAMSSTTVAAVLPAVPSTTTEREPQKTSSSPSPTKATSS 1335
            .|...:.:|:        ..::.|..:....|||....|....|||  ..|:|:..|..:.....
  Fly  1168 GSTTREEDTT--------VAIETTTEKPEDDTTVEDSTPIPEETTT--VGQETTYDPEGSTTRED 1222

  Fly  1336 TTTQPIETTTGDLEYDSS--GSSDYVNDANDISSGVVNSLEARKNFLLSLLKQRLTQIE-RTEAK 1397
            .||..|:|||...|.|::  .|:....::..::....|..|.      |..::..|.:. .|..:
  Fly  1223 DTTVAIDTTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEG------STTREDDTTVAIDTTTE 1281

  Fly  1398 KPATSTSTTTDAPKTSSSSTSPASTTSE---STSPVTSSTARSSLTASKHLGPEALSRQKSLTP- 1458
            ||...|:.....|....|:|....||::   ||:....:|.....|..|   ||..:..:..||
  Fly  1282 KPEDDTTVEDSTPIPEESTTVAQDTTNDPEGSTTREDDTTVAIDTTTEK---PEDDTTVEDSTPI 1343

  Fly  1459 --------QSAEYYDEDDDYMEDEPVGS--SDAEKKEHGTVLISE----KQAAATAKRHIAPPSA 1509
                    |...|..|.....||:...:  :..||.|..|.:...    :::...|:.....|..
  Fly  1344 PEESTTIAQETTYDPEGSTTREDDTTVAIETTTEKPEDDTTVEDSTPIPEESTTVAQDTTNDPEG 1408

  Fly  1510 QPLRQAMLNILATRSEENKVDLKTTSDGLQFRRF--ESSQIP-------------TEGPPNRA-- 1557
            .          .||.|:..|.::||::..:....  :|:.||             .||...|.
  Fly  1409 S----------TTREEDTTVAIETTTEKPEDDTTVEDSTPIPEETTTVGQETTYDPEGSTTREDD 1463

  Fly  1558 SIVVAEALSRRLADN--VGEHLPGP----TVPH--TSDAKAISSVSQTTIRSRESQTKSSSQTPP 1614
            :.|..|..:.:..|:  |.:..|.|    ||..  |.|.:..::...||:....:..|....|..
  Fly  1464 TTVAIETTTEKPEDDTTVEDSTPIPEETTTVAQETTYDPEGSTTRDDTTVAIETTTEKPEDDTTA 1528

  Fly  1615 SISTETPATQAIQNHRTDEATQSTLEIVTQTTPKSAPPATAVPVAVRQEVLSVNSRPWLLAARNQ 1679
            ..||..|.|....|..|.....||: :.|...||.:       ..:....||        ...|.
  Fly  1529 EGSTPIPDTSTTVNQDTTTDESSTV-VTTTNIPKES-------TTLGDSTLS--------PGENS 1577

  Fly  1680 TV-HLTPISSIAARAPSNPVSHANRS--INPLVSSPEDHSTEKVPQLIVKVYEPIDLKIVFCPKS 1741
            |. .::..:::.....|:|:..::||  :.|..||..:.:|..:|                 |.|
  Fly  1578 TAGQVSTSTTLVYDTTSSPIPSSSRSTTLEPSSSSSPETTTSSLP-----------------PLS 1625

  Fly  1742 CDQDHDHKFDPADNIKTSNCTGG 1764
            |...:.:...|.:..|..:|:.|
  Fly  1626 CSTGYQYLPHPTNCHKYIHCSNG 1648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696
		CBM_14	150..197	CDD:279884
		CBM_14	221..275	CDD:279884
Muc68E	NP_996064.1	ChtBD2	<1761..1791	CDD:214696
		ChtBD2	1626..1668	CDD:214696	5/23 (22%)
		ChtBD2	1688..1734	CDD:214696
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23301
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100