DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mur2B and Hcfc1

DIOPT Version :9

Sequence 1:	NP_001284789.1	Gene:	Mur2B / 31111	FlyBaseID:	FBgn0025390	Length:	1795	Species:	Drosophila melanogaster
Sequence 2:	XP_006527898.1	Gene:	Hcfc1 / 15161	MGIID:	105942	Length:	2090	Species:	Mus musculus

Alignment Length:	1578	Identity:	354/1578 - (22%)
Similarity:	535/1578 - (33%)	Gaps:	387/1578 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 LELEKEGVPRKLKL-----------------SENIVIQ---PETPATAATTREPLNDINKYQYKR 424
            ||.||...|.:::|                 :::.::|   .:.||||||...|
Mouse   359 LETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIPATAATATSP----------- 412

  Fly   425 YTYGTDKNDV---------TEAPEIKSPLKGLHLSENIVILPETTTTTTTTTKPVVLTCPTISPP 480
                 ..|.|         :.||...:|.........|.::|:..|...:||...||  ||: |.
Mouse   413 -----TPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAATAPPSTTTIQVL--PTV-PG 469

  Fly   481 DTTPKPSTTTAVTKSTPKISSTEQHSTTTAKTTTTKRPTTVTEKTS-SATEKPRTTVVTTTTQKR 544
            .:...|  |.|.|:..|.:........||.....|.||.:...|.. :.|..|.:..:...||..
Mouse   470 SSISVP--TAARTQGVPAVLKVTGPQATTGTPLVTMRPASQAGKAPVTVTSLPASVRMVVPTQSA 532

  Fly   545 STTTHNTSPDTKTTIRSTTLSPKTTTTPSTTTPST-TTPSTTTPSTT---TPSTTTPSTTTPSTT 605
            ..|...::|...........:..|...|.::.|:. :.|:.||...|   ||.|||...|....:
Mouse   533 QGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTIVKTVAVTPGTTTLPATVKVAS 597

  Fly   606 TTVKVSTHRPRTTSQKTTTASTTTKKTTTSPKTTKTTDIPTSTTSKLSTTT-----QKTTTTTHK 665
            :.|.||  .|.|...||..|...|..::.:..:|:    |..|..|..|.|     |..||....
Mouse   598 SPVMVS--NPATRMLKTAAAQVGTSVSSAANTSTR----PIITVHKSGTVTVAQQAQVVTTVVGG 656

  Fly   666 FTAATTSTEKPKTTTEKTSTVSTTTKKSTESSPKPTSS---TGKPTTTPKPSTRTTP------TT 721
            .|...|..:.|.:....::.:|...|..:....||..:   ||:.:|.|......|.      |.
Mouse   657 VTKTITLVKSPISVPGGSALISNLGKVMSVVQTKPVQTSAVTGQASTGPVTQIIQTKGPLPAGTI 721

  Fly   722 TKVTT------TTQITTTTPLRSSTETT----STQPPTTTTPQPTTTTTLTVTPKTSTTTTTTEK 776
            .|:.|      ||.||||....:.|:.|    |:..|:||  :|.|||.:...|.::..|.....
Mouse   722 LKLVTSADGKPTTIITTTQASGAGTKPTILGISSVSPSTT--KPGTTTIIKTIPMSAIITQAGAT 784

  Fly   777 PITSSP---KPTT--TTQKTTSTAPNTTKVAITTQKETTPTQSTSTTIFTRKTTTNNP------E 830
            .:||||   .|.|  ||:..||......|:.....|..|.......|....|.....|      .
Mouse   785 GVTSSPGIKSPITIITTKVMTSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTV 849

  Fly   831 PTSTEK---PITSTTPKPSTTTPKTSTVASSTEKTTISSPKPTTEKSTENPTTNSVKTSALTSST 892
            |....:   |:|.:..||:.|   |..|..:|..||:.:...|...|......:|...|..|..|
Mouse   850 PMGGVRLVTPVTVSAVKPAVT---TLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPIT 911

  Fly   893 QRATSTTSEPTKTTQNITTTTPKPTTLKTSTQEATTST---QKVSTVT----ITTKKATESSPLT 950
            ...|..|...........|.:...||| |:....||.|   |.||..|    ||.....|:.|:.
Mouse   912 TLGTIATLSSQVINPTAITVSAAQTTL-TAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVH 975

  Fly   951 TL--STEEPNTTPKPLRTTT---------------------PTTTSVTATTRITTTTI------- 985
            .|  |.....||.:|..|.|                     |..|..|.||...|||:
Mouse   976 DLPVSILASPTTEQPTATVTIADSGQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGH 1040

  Fly   986 --------------SESSTETTS------------TQKPKSTTPTSTTRTTPKVTTVIV---STQ 1021
                          :.:|..|::            :..|..|..|.||.|....|:.:.   ...
Mouse  1041 PQPTQVQFVCDRQETAASLVTSAVGQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCS 1105

  Fly  1022 NPTTTTSKTSTV-TITTPNPSPST--QRPT-TTTRQPTSITASTTSIGTTRIPTTTNPQNSTSST 1082
            ||...|.:|.|. |.||...|..|  ||.| .||..||.:..:.......|:..|..||..|..|
Mouse  1106 NPPCETHETGTTSTATTAMSSMGTGQQRDTRRTTNTPTVVRITVAPGALERVQGTVKPQCQTQQT 1170

  Fly  1083 DLTTVTR------PPCP-----DPDSTSDKNTNTACTQELQQVNL-LELQSPQ-------KQEQF 1128
            ::||.|.      .||.     .|....:..:::....:|...:: :.|..|.       :|.:.
Mouse  1171 NMTTTTMTVQATGAPCSAGPLLRPSVALESGSHSPAFVQLALPSVRVGLSGPSSKDMPTGRQPET 1235

  Fly  1129 THTRTHTALTGSRN-----TLGGQEVPDYMDDAPSSAEAESGQATTAKAPTMSTLAAAHLLQKLF 1188
            .||.|....|.:|:     .||...|      .|:|. .||.||::..: ||:..|...||
Mouse  1236 YHTYTTNTPTTTRSIMVAGELGAARV------VPTST-YESLQASSPSS-TMTMTALEALL---- 1288

  Fly  1189 HIISTTPPSREHAPTQRPSSQPSSSQRSRGVTIAQMARHNLATSKPFIAHSLRLSIQQLASTQKR 1253
                  .||   |...:..|.|.......|.|       |.||:      |...|.|::.|.
Mouse  1289 ------CPS---ATVTQVCSNPPCETHETGTT-------NTATT------SNAGSAQRVCSN--- 1328

  Fly  1254 SIPP----KTLVTHNTTKEPEDSEYYDSETSEQYTDEDNEVLDKTQPRAMSSTTVAAVLPAVPST 1314
              ||    :|..||..|....:......|..:|                          ||
Mouse  1329 --PPCETHETGTTHTATTATSNGGAGQPEGGQQ--------------------------PA---- 1361

  Fly  1315 TTEREPQKTSSSPSPTKATSSTTTQPIETTTGDLEYDSSGSSDYVNDANDISSGVVNSLEARKNF 1379
                     |..|..|..|:||.| .:..:.|.|..|::.|...:....::.:....:.:|....
Mouse  1362 ---------SGHPCETHQTTSTGT-TMSVSVGTLIPDATSSHGTLESGLEVVAVPTVTSQAGSTL 1416

  Fly  1380 LLSLLKQRLTQIERTEAKKPATSTSTTT---------DAPKTSSSSTSPASTTSESTSPVTSSTA 1435
            |.|...||:......|..:..|:.:.||         |.|..:|.....|||..:||:..::|..
Mouse  1417 LASFPTQRVCSNPPCETHETGTTHTATTVTSNMSSNQDPPPAASDQGEVASTQGDSTNITSASAI 1481

  Fly  1436 RSSLTASKHLGPEALSRQKSLTPQSAEYYDEDDDYMEDEPVGSSDAEKKEHGTVLIS-------- 1492
            .:|::::.   |.|::.....||.............|..| |:.::|.....|:.::
Mouse  1482 TTSVSSTL---PRAVTTVTQSTPVPGPSVPNISSLTETTP-GALNSEVPIPATITVTIANTETSD 1542

  Fly  1493 ------------EKQAAATAKRHIAPP------SAQPLRQAMLNILA---TRSEENKVDLKTTSD 1536
                        |:...:...|...||      ::.||......:|:   |...:..|||.:|.|
Mouse  1543 MPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMGESTEVLSASQTPELQAAVDLSSTGD 1607

  Fly  1537 GLQFRRFESSQIPTEGPPNRASIVVAEALSRRLADNVGEHLPGPTVPHTSDAKAISSVSQTTIRS 1601
                        |:.|.....|.|||..:.:            |..|..|:...: |:.|..:..
Mouse  1608 ------------PSSGQEPTTSAVVATVVVQ------------PPPPTQSEVDQL-SLPQELMAE 1647

  Fly  1602 RESQTKS---SSQTPPSISTETPATQAIQNHRTDEATQSTLEIVTQT--------------TPKS 1649
            .::.|.:   :..||..::....|..|.|...|:||....::.|.|.              |.::
Mouse  1648 AQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEA 1712

  Fly  1650 AP-----------------PATAVPVAVRQEVLS--VNSRPWL--LAARNQTVHLTPISSIAARA 1693
            |.                 .||.:|:.:.|:.|:  |..:..|  ..|:.|..|..|..::|...
Mouse  1713 AAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPAD 1777

  Fly  1694 PSNPVSHANRSINPLVSS 1711
            ..|..|..:..:|.|.|:
Mouse  1778 SLNDPSIESNCLNELASA 1795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mur2B	NP_001284789.1	ChtBD2	88..136	CDD:214696
		CBM_14	150..197	CDD:279884
		CBM_14	221..275	CDD:279884
Hcfc1	XP_006527898.1	PLN02193	<27..322	CDD:177844
		KELCH repeat	33..80	CDD:276965
		KELCH repeat	84..134	CDD:276965
		KELCH repeat	137..196	CDD:276965
		KELCH repeat	200..253	CDD:276965
		KELCH repeat	255..319	CDD:276965
		Kelch_5	319..>351	CDD:372758
		KELCH repeat	322..367	CDD:276965	4/7 (57%)
		Herpes_BLLF1	<441..771	CDD:282904	89/342 (26%)
		FN3	<1911..1940	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000