DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and Ir75b

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001137966.2	Gene:	Ir75b / 8673994	FlyBaseID:	FBgn0261402	Length:	605	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	79/421 - (18%)
Similarity:	142/421 - (33%)	Gaps:	117/421 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 DGKWGTLENGKWN------GLIADLVNRKTDMVLTSLMINTER----EAVVDFSEPFMETGIAIV 643
            |.|:..:...:|:      |:|.||:..|.|:.:...:.:.:|    :.:..|| .|.|..:...
  Fly   240 DCKFKYIFRDRWSDGNATGGMIGDLILDKADLAIAPFIYSFDRALFLQPITKFS-VFREICMFRN 303

  Fly   644 VAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIFLF------EWLSPSGYDMKLYLQNTNV 702
            ....:..:|.|.||:||....|:...::.:.|...:...|      :| .||       |..:.:
  Fly   304 PRSVSAGLSATEFLQPFSGGVWLTFALLLLLAGCLLWVTFILERRKQW-KPS-------LLTSCL 360

  Fly   703 TPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLA-----IYTANLAAFMI 762
            ..:.....:..||             :||....|.     |.||::..:     .||:.:.:.::
  Fly   361 LSFGAGCIQGAWL-------------TPRSMGGRM-----AFFALMVTSYLMYNYYTSIVVSKLL 407

  Fly   763 ---TREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTS---- 820
               .:........|.||.|          ..|..|      |:         |.|.|.:||
  Fly   408 GQPIKSNIRTLQQLADSNL----------DVGIEP------TV---------YTRIYVETSEEPD 447

  Fly   821 VADGVAAVLNGNLDS--FIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGL-------------- 869
            |.|.....:.|:..|  .|:..|....|..:|::..:...|   ..|||..
  Fly   448 VRDLYRKKVLGSKRSPDKIWIPTEAGVLSVRDQEGFVYITG---VATGYEFVRKHFLAHQICELN 509

  Fly   870 ------------AFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGT--CRPGKQEHKSSDPLA 920
                        ..::.|.|.::.....|.....|...:..|.||...  |    .:|..:..:.
  Fly   510 EIPLRDASHTHTVLAKRSPYAELIKLSELRMLETGVHFKHERSWMETKLHC----YQHNHTVAVG 570

  Fly   921 LEQFLSAFLLLMAGILLAALLLLLEHVYFKY 951
            ||.....|::|:..|:|...:|.||.::.::
  Fly   571 LEYAAPLFIILLGAIILCMGILGLEVIWHRH 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	69/376 (18%)
		Lig_chan	665..928	CDD:278489	52/310 (17%)
Ir75b	NP_001137966.2	Periplasmic_Binding_Protein_Type_2	253..553	CDD:304360	63/354 (18%)
Ir75b	NP_001137966.2	Lig_chan	343..585	CDD:278489	52/299 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462785
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740