DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR1.3

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_199652.1	Gene:	GLR1.3 / 834896	AraportID:	AT5G48410	Length:	860	Species:	Arabidopsis thaliana

Alignment Length:	971	Identity:	196/971 - (20%)
Similarity:	342/971 - (35%)	Gaps:	263/971 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNF-GK---------REY 117
            ||..:|.||:..:||....:..:..|       ..:.|:.:||:....:. ||         ..|
plant    11 LLSFLLVLLLFISRSFASTKNDDVDG-------GKRVQIRVGLVLDLGSLKGKIVKNSVSMALSY 68

  Fly   118 LRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYM 182
            ..:|:|..    |||         .|...:|.|.:.:....|...:|.|       ..|.||:
plant    69 FYAIHNDY----KTR---------VSVSLRNSHGEPLLALASAVDLLKT-------EGVEAII-- 111

  Fly   183 MNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSIL 247
                 .|:|...|:...:|.....:|:||.   :|......|:.|..:|.......::..:.|.:
plant   112 -----GGNSLLEAKLLGELGEKARVPMISL---DSPFSLSLSKYTHLIQATHDSTSEAKGITSFI 168

  Fly   248 ERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFK-----------FTILNS--IVVTRTSDL 299
            ..:.|:..::|...   |||:    ||.:..:.|||.           ||:.:|  .|:.|...|
plant   169 NVFDWNSVALVYED---HDDW----RESMQLLVEHFHENGVRVQSKVGFTVSSSEDFVMGRLQQL 226

  Fly   300 MELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEK-----KDAHSQFPVGML 359
            .:|..:   |.:::.::..|..:...|..:.|.|:.:||:::...:..     .|...|...|::
plant   227 KDLGTT---VFVVHLSEVIATHLFPCARRLGLMGDGFVWILTAKTMNSFHENIDDFTKQAMEGVV 288

  Fly   360 GVHFDTSSAALMNEISNAIKIYSYGVEAYLTDPANRDRRLTTQSLSCEDEGRGRWDNGEIFFKYL 424
            |         ..:.|..:|::.::.:....:.|. .:..||..|:|      |.|.: :|.|...
plant   289 G---------FKSYIPMSIELQNFTLRWRKSLPV-EEAELTRLSIS------GIWAH-DIAFALA 336

  Fly   425 RNVSIEGDLNKPNIEFTA-------------------DGDLRSAELKIMNLRPS----------- 459
            |...:   :..||:..|.                   |..|.|.:.:|:|:..|
plant   337 RAAEV---IRMPNVTSTLLEEITKTRFNGLSGDFQLNDKKLLSNKFEIINMIGSSERRVGFLNSN 398

  Fly   460 ---ANNKNLVWEEIGVWKSWETQKLDIRDIAWPGNSHAPPQGVP------EKFHLKITFLEEAPY 515
               :|.::|         |....||:  .|.|||.|...|:|..      :|..:.:|.....|.
plant   399 GSFSNRRHL---------SSTHNKLE--TIIWPGGSAQSPKGTSLIDSDRKKLRVLVTSSNRFPR 452

  Fly   516 INLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGF 580
            :.....|||:.:.:::                                 ||||::..  |....|
plant   453 LMKVETDPVTNELIVE---------------------------------GFCIEVFR--ASISPF 482

  Fly   581 TYELVRVEDGKWGTLENGKWNGLIADLVNRKT--DMVLTSLMINTEREAVVDFSEPFMETGIAIV 643
            .||   ||...|  |....::.|...|.::|.  |..:..:.|.:.|...|||:.||.|.|:.||
plant   483 NYE---VEYIPW--LNGSNYDNLAYALHSQKDKYDAAVGDITITSNRSTYVDFTLPFTEMGLGIV 542

  Fly   644 VAKRTGIISPTAFLEPFDTASW-------MLVGIVA--IQAATFMIFLFEWLSPSGYDMKLYLQN 699
            ..|..   |...|.:|.....|       :|.|::.  |:.|....|...|....|.
plant   543 AVKER---SMWVFFQPLTPDLWITSAFFFVLTGVIVWLIERAENKEFQGSWPQQIGV-------- 596

  Fly   700 TNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITR 764
                        ..|..::.|..|  |.:..:...|||:..||....::..|.|||.|.:.|..:
plant   597 ------------VLWFGFSTLVYA--HREKLKHNLSRFVVTVWVFAVLILTASYTATLTSMMTVQ 647

  Fly   765 EEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNY---------MRQYNKTS 820
            :                      .:|.    |:.|...|...:::.|.         ||.....|
plant   648 Q----------------------IRFN----SNEDYVGHLSGSLIANVALTSSSLRAMRSLGLNS 686

  Fly   821 VADGVAAVLNGNLDSFIYDGTVLDYL--VAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNK 883
            .||...|:||..: ||:.|  .|.||  |..:.......|.:.....|:|..|.:..:.|...::
plant   687 AADYAQALLNKTV-SFVVD--ELPYLKVVLGENPTHFFMVKTQSTTNGFGFMFQKGFELVPNVSR 748

  Fly   884 RLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLL 944
            .:.:.|.:..|..:.:.|..........:  :|:|:.|.:|...|:::......|..:|::
plant   749 EISKLRTSEKLNEMEKRWFDNQLPYTTDD--TSNPITLYRFRGLFIIIGVSFAFALAVLVI 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	88/451 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	88/427 (21%)
		Lig_chan	665..928	CDD:278489	55/282 (20%)
GLR1.3	NP_199652.1	PBP1_GABAb_receptor	43..405	CDD:107361	81/421 (19%)
		ANF_receptor	57..385	CDD:279440	75/387 (19%)
		GluR_Plant	438..767	CDD:270404	87/422 (21%)
		Lig_chan	559..798	CDD:278489	56/291 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910