DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and ATGLR1.2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_199651.1	Gene:	ATGLR1.2 / 834895	AraportID:	AT5G48400	Length:	867	Species:	Arabidopsis thaliana

Alignment Length:	986	Identity:	198/986 - (20%)
Similarity:	358/986 - (36%)	Gaps:	257/986 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ILTPPSGPISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKRE 116
            |.||       :||:.|.:|:....:|......|...        .:.::.:||:..
plant     6 IQTP-------ILLSFLLVLLFFISNCFASSQNNDDD--------KRIRVRVGLVLD-------- 47

  Fly   117 YLRSINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLT-----PSPTAILSTLCKEFLRVNV 176
             |.|:...:     .|.:....|.|: ::..|.:...:||.     ..|...|.::........|
plant    48 -LGSVEGKI-----VRSSVSMALSDF-YDNHNDYKTRLSLLVRDSHGEPLLALDSVVDLLQTEGV 105

  Fly   177 SAILYMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSA 241
            .||:       .|:|...|:...:|.....:||||.   ||.:....|:.|..:|...:...:..
plant   106 QAII-------GGNSLLEAKLLAELGEKARVPVISL---NSPMSLSLSKYTHLIQATHNSASEVK 160

  Fly   242 AMLSILERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTILN-----SIVVTRTSD--- 298
            .:.:.|..:.|:..::|   :..|||:    ||.:..|.:||....::     :..||.:.|
plant   161 GITAFLHGFDWNSVALV---LEDHDDW----RESMHFMVDHFHENNVHVQSKVAFSVTSSEDSLM 218

  Fly   299 --LMELVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVV-SQSVIEKKDAHSQF-----P 355
              |.||.:....|.:::.::..|..:...||::.:.||.:.|:: |:|:   ...|.||     .
plant   219 DRLRELKDLGTTVFVVHLSEVIATRLFPCAEKLGMMGEGFAWILTSRSM---SSFHDQFIDDLTK 280

  Fly   356 VGMLGVHFDTSSAALMNEISN----------------------AIK-IYSYGVEAYLTDPANRDR 397
            ..|.||....|...:..|:.|                      :|. ::::.|...|...|...|
plant   281 EAMEGVVGFKSYIPMSKELHNFTLRWRKTLPVEEVTGSEITRLSISGVWAHDVAWSLASAAEVTR 345

  Fly   398 RLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANN 462
            ..|..|...|.....|       ||     .:.|:....:::..:|      :.:|:|:..|...
plant   346 MPTVTSTLLEAIKESR-------FK-----GLSGNFQLDDMKLLSD------KFEIVNMIGSGER 392

  Fly   463 KNLVWEEIGVWKS---------WETQKLDIRDIAWPGNSHAPPQGVP------EKFHLKITFLEE 512
            :      :|.|.|         ..:...::..|.|||.|...|:|..      :|..:.:|....
plant   393 R------VGFWNSNGSFSNRRQLSSTHDNLETIIWPGGSAQSPKGRSLRESGRKKLRVLVTSSNR 451

  Fly   513 APYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEE 577
            .|.:.....||::                ||:.                ...||||::.:  |..
plant   452 FPRLMKVETDPIT----------------HEIT----------------IVEGFCIEVFQ--ASI 482

  Fly   578 LGFTYELVRVEDGKWGTLENGKWNGLIADLVNRKT--DMVLTSLMINTEREAVVDFSEPFMETGI 640
            ..|.||   ||..:|  |....:..|...|.::|.  |..:..:.|.::|...|||:.|:.|.|:
plant   483 APFNYE---VEYIRW--LNGTNYTKLAYALHSQKDKYDAAVGDITITSDRSMYVDFTLPYTEMGL 542

  Fly   641 AIVVAKRTGIISPTAFLEPFDTASW-------MLVGIVA--IQAATFMIFLFEWLSPSGYDMKLY 696
            .||.||..   |...|.:|.....|       :|.||:.  |:.|....|...|....|.
plant   543 GIVAAKER---SMWVFFQPLTPNLWITSAAFFVLTGIIVWLIERAENKEFQGSWPQQIGV----- 599

  Fly   697 LQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFM 761
                           ..|..::.|..|  |.:..:...|||:..||....::.:..|||.|.:.|
plant   600 ---------------VIWFGFSTLVYA--HREKLQHNLSRFVVTVWVFAVLILVTSYTATLTSMM 647

  Fly   762 ITRE-EFH---EFSG-LNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSV 821
            ..:: .|:   ::.| |:.|.:.:.              :.|:|::..        ||.....:.
plant   648 TVQQIRFNANEDYVGHLSGSLIANA--------------ALTNSSLRA--------MRLLGLNTS 690

  Fly   822 ADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLL 886
            .|...|::|.::...:.:...|..|:.::....|| |.:.....|:|..|.:.|:.....::.:.
plant   691 EDYAQALMNKSVSYIVSELPYLKILLGENPGHFLM-VKTQSTTNGFGFMFQKGSELAPNVSREIA 754

  Fly   887 EFRANGDLERLRRYWMTGTCRPGKQ----EHKSSDPLALEQFLSAFLLLMAGILLA---ALLLLL 944
            :.|.:..|..:.|.|.      .||    ...:|:|:.|.:|...|::  .|:..|   |:||:|
plant   755 KLRTSERLNEMERRWF------DKQLPYTTDDTSNPITLYRFRGLFMI--TGVSFAFALAVLLIL 811

  Fly   945 EHVYFKYIRKR 955
                  ::|:|
plant   812 ------WLRER 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	84/443 (19%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	85/421 (20%)
		Lig_chan	665..928	CDD:278489	53/280 (19%)
ATGLR1.2	NP_199651.1	PBP1_GABAb_receptor	41..407	CDD:107361	82/424 (19%)
		ANF_receptor	55..387	CDD:279440	74/375 (20%)
		GluR_Plant	440..770	CDD:270404	84/416 (20%)
		Lig_chan	563..801	CDD:278489	55/290 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910