DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR2.5

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001332219.1	Gene:	GLR2.5 / 830991	AraportID:	AT5G11210	Length:	918	Species:	Arabidopsis thaliana

Alignment Length:	966	Identity:	190/966 - (19%)
Similarity:	369/966 - (38%)	Gaps:	201/966 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ISLLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKE--QLNIGLIAPHTNFGKREYLRSIN 122
            :||.||..|..|:|               ||.|   :.||  |:.:|::...........||:||
plant    12 LSLWLLIFLVFLVL---------------SLGK---SQKEALQVKVGIVLGSNVTLADLSLRAIN 58

  Fly   123 NAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQ 187
            .:::....|.....|.:             ::::..|...::..         .::.||::...:
plant    59 MSLSEFYNTHNGFKTRI-------------VLNVRDSKQTVVGA---------AASALYLIKKRE 101

  Fly   188 ----FGHSTA-SAQYFLQLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSIL 247
                .|..|: .|.:.:.|.....:|:||::|.:..|:  :.:|...::.......|..|:.:|:
plant   102 VVAIIGPGTSMQAPFLINLGNQSKVPIISFSATSPLLD--SLRSPYFIRATHDDSSQVQAISAII 164

  Fly   248 ERYKWHQFSVVTSQIAGHDDFVQAVRERVAEMQEHFKFTI-LNSIVVTRTSD------LMELVNS 305
            |.::|.:  ||...:  .::|.:.:...:.:..:.....| ..|.:....||      |.:|:..
plant   165 ESFRWRE--VVPIYV--DNEFGEGILPNLVDAFQEINVRIRYRSAISLHYSDDQIKKELYKLMTM 225

  Fly   306 EARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPV----GMLGV--HFD 364
            ..||.:::........:...|:|:.:..:.|||:|:..:.:......:..:    |:|||  :|.
plant   226 PTRVFIVHMLPDLGSRLFSIAKEIDMLSKGYVWIVTNGIADLMSIMGESSLVNMHGVLGVKTYFA 290

  Fly   365 TSSAALM----------NEISNAIKIYSYGVEAYLTDPANRDRRL------TTQSLSCEDEGR-- 411
            .|...|.          .|..|....::|.....|.......|.:      |.:..|.:|.|.
plant   291 KSKELLHLEARWQKRFGGEELNNFACWAYDAATALAMSVEEIRHVNMSFNTTKEDTSRDDIGTDL 355

  Fly   412 ---GRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNLVWE-EIGV 472
               |...:|......|..||.:|...:..::   :|.|.:...||:|:..|.......|: ::|:
plant   356 DELGVALSGPKLLDALSTVSFKGVAGRFQLK---NGKLEATTFKIINIEESGERTVGFWKSKVGL 417

  Fly   473 WKSWETQKLD-----IRDIAWPGNSHAPPQGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDR 532
            .||....|:.     :|.|.|||::...|:|  .:|                   |.:.|.|
plant   418 VKSLRVDKVSHSSRRLRPIIWPGDTIFVPKG--WEF-------------------PTNAKKL--- 458

  Fly   533 GVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGF--TYELVRVE--DGK-W 592
                |:|...:...:..|.......:.....:|||||:......::.:  :||.:..:  ||| .
plant   459 ----RIAVPKKDGFNNFVEVTKDENTNVPTVTGFCIDVFNTVMSQMPYAVSYEYIPFDTPDGKPR 519

  Fly   593 GTLEN-------GKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVAKRTG- 649
            |:.:.       |:::|.:.|          |:::.|  |...|||:.|:.||||..:|..:.|
plant   520 GSYDEMVYNVFLGEFDGAVGD----------TTILAN--RSHYVDFALPYSETGIVFLVPVKDGK 572

  Fly   650 IISPTAFLEPFDTASWMLVGIVAIQAATF-----MIFLFEWLSPSGYDMKLYLQNTNVTPYRFSL 709
            ......||:|.....|:      :.||:|     |:::||:.:...:..::.:.         .:
plant   573 EKGEWVFLKPLTKELWL------VTAASFLYIGIMVWIFEYQADEEFREQMIID---------KI 622

  Fly   710 FRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLN 774
            ...::..::.||.|  |......|.:|.:..||....::....|||.|.:.:..:|.......::
plant   623 SSVFYFSFSTLFFA--HRRPSESFFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVRHMD 685

  Fly   775 DSRL--VHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQ--YNKTSVADGVAAVLNGNLDS 835
            |.|.  |:......||.|..:.....|.:..|.:|.... ||:  .:|:|         ||.:|:
plant   686 DLRKSGVNIGYQTGSFTFERLKQMRFDESRLKTYNSPEE-MRELFLHKSS---------NGGIDA 740

  Fly   836 FIYDGTVLDYLVAQDEDC-RLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRR 899
            ...:...:...:|  :.| ....:...:...|:|.||...|..|...::::|.......::.:..
plant   741 AFDEVAYIKLFMA--KYCSEYSIIEPTFKADGFGFAFPLGSPLVSDISRQILNITEGDAMKAIEN 803

  Fly   900 YWMTGTCRPGKQEH-----KSSDPLALE--QFLSAFLLLMAGILLAALLLLLEHVY 948
            .|..|      ::|     .|..|:.|:  .|.:.||::....::..||:|....|
plant   804 KWFLG------EKHCLDSTTSDSPIQLDHHSFEALFLIVFVVSVILLLLMLASRGY 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	80/437 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	84/428 (20%)
		Lig_chan	665..928	CDD:278489	52/279 (19%)
GLR2.5	NP_001332219.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910