DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLUR2

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	1032	Identity:	218/1032 - (21%)
Similarity:	400/1032 - (38%)	Gaps:	227/1032 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLLLTVLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLI-------APHTNFGKREYLR 119
            |:||:.:.|:              |.|.:|:||......:::|.|       ...||...:....
plant     5 LVLLSFIVLI--------------GDGMISEGAGLRPRYVDVGAIFSLGTLQGEVTNIAMKAAEE 55

  Fly   120 SINNAVTGLTKTRGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLRVNVSAILYMMN 184
            .:|:..:.|   .|:||...   :::.|...|    ||     |:..|  :|:..:..||:
plant    56 DVNSDPSFL---GGSKLRIT---TYDAKRNGF----LT-----IMGAL--QFMETDAVAII---- 99

  Fly   185 NEQFGHSTASAQYFL-QLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILE 248
                |..|:...:.| .||..|.:|::|:.|.:..|.  |.|....:|.|||......|:..::.
plant   100 ----GPQTSIMAHVLSHLANELSVPMLSFTALDPSLS--ALQFPFFVQTAPSDLFLMRAIAEMIS 158

  Fly   249 RYKWHQFSVVTSQ-------IAGHDDFVQAVRERVAEMQEHFKFTILNSIVVTR----TSDLMEL 302
            .|.|.:...:.:.       |....|.::..|.:::     :|..:...:|:|.    .::|:::
plant   159 YYGWSEVIALYNDDDNSRNGITALGDELEGRRCKIS-----YKAVLPLDVVITSPREIINELVKI 218

  Fly   303 VNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVV---------SQSVIEKKDAHSQFPVGM 358
            ...|:||:::.........|...|:::.:..:.|||:.         |.:.:..|.|.|...|..
plant   219 QGMESRVIIVNTFPKTGKKIFEEAQKLGMMEKGYVWIATTWLTSLLDSVNPLPAKTAESLRGVLT 283

  Fly   359 LGVHFDTSS-----AALMNEISN-AIKIYSYGVEAY-------------LTDPAN----RDRRLT 400
            |.:|...|.     .|..|::|| .:.:..||:.||             |...||    .|.:||
plant   284 LRIHTPNSKKKKDFVARWNKLSNGTVGLNVYGLYAYDTVWIIARAVKRLLDSRANISFSSDPKLT 348

  Fly   401 TQSLSCEDEGRGR--------WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLR 457
            :.      :|.|.        :|.|..|..|:.|.::.|...:  |:|..|..:         ::
plant   349 SM------KGGGSLNLGALSIFDQGSQFLDYIVNTNMTGVTGQ--IQFLPDRSM---------IQ 396

  Fly   458 PSANNKNLV---WEEIGVW--------------------KSWETQKLDIRDIAWPGNSHAPPQGV 499
            ||.:..|:|   :.:||.|                    :|...|.|:  ::.|||.:...|:|
plant   397 PSYDIINVVDDGFRQIGYWSNHSGLSIIPPESLYKKLSNRSSSNQHLN--NVTWPGGTSETPRG- 458

  Fly   500 PEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCS 564
                   ..|......:.:...|..|.|               |..:.:|....         ..
plant   459 -------WVFPNNGRRLRIGVPDRASFK---------------EFVSRLDGSNK---------VQ 492

  Fly   565 GFCIDLLEKFAEELGF--TYELVRVEDGKWGTLENGKWNGLIADLVNRKTDMVLTSLMINTEREA 627
            |:.||:.|...:.:.:  .:|.|...||    |:|..:|..:.::.....|.|:..:.|.|:|..
plant   493 GYAIDVFEAAVKLISYPVPHEFVLFGDG----LKNPNFNEFVNNVTIGVFDAVVGDIAIVTKRTR 553

  Fly   628 VVDFSEPFMETGIAIVVAKRTGI-ISPTAFLEPFDTASWMLVGIVAIQAATFMIF-LFEWLSPSG 690
            :|||::|::|:|: :|||..|.: .:|.|||.||....|      |:.||.|:|. ...|:
plant   554 IVDFTQPYIESGL-VVVAPVTKLNDTPWAFLRPFTPPMW------AVTAAFFLIVGSVIWI---- 607

  Fly   691 YDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTA 755
              ::..:.:....|.|..:....|..::.:|.:  |.::......|.:..:|....::..:.|||
plant   608 --LEHRINDEFRGPPRKQIVTILWFSFSTMFFS--HRENTVSTLGRAVLLIWLFVVLIITSSYTA 668

  Fly   756 NLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTS 820
            :|.:.:..::......|::  .|:.. |.:..|:.|    |:.::.:....|:..:  |.....|
plant   669 SLTSILTVQQLNSPIRGVD--TLISS-SGRVGFQVG----SYAENYMIDELNIARS--RLVPLGS 724

  Fly   821 VADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
            ..:..||:.||.:.:.:.:...:|..::  |.|.....|..:..:|:|.||.|:|......:..:
plant   725 PKEYAAALQNGTVAAIVDERPYVDLFLS--EFCGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAI 787

  Fly   886 LEFRANGDLERLRRYWMT-GTCR--PGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHV 947
            |.....|.|:::...|:: ..|.  .|....:.|:.|.|..|...||:......:|..:     .
plant   788 LGLSETGQLQKIHDKWLSRSNCSNLNGSVSDEDSEQLKLRSFWGLFLVCGISCFIALFI-----Y 847

  Fly   948 YFKYIRK--RLAKKDGGHCCALISLSMGKSLTFRGAVFEATEILKKHRC----NDPI 998
            :||.:|.  |..|.|..........|..|||....|.|:..|...|.|.    ||.:
plant   848 FFKIVRDFFRHGKYDEEATVPSPESSRSKSLQTFLAYFDEKEDESKRRMKRKRNDDL 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	96/472 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	84/412 (20%)
		Lig_chan	665..928	CDD:278489	51/266 (19%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	92/439 (21%)
		GluR_Plant	466..804	CDD:270404	81/391 (21%)
		Lig_chan	590..840	CDD:395014	53/274 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910