DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR3.6

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_001326369.1	Gene:	GLR3.6 / 824311	AraportID:	AT3G51480	Length:	903	Species:	Arabidopsis thaliana

Alignment Length:	971	Identity:	196/971 - (20%)
Similarity:	365/971 - (37%)	Gaps:	241/971 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VLTLLILDTRSCQGLRLTNGGGSLSKGAAANKEQLNIGLIAPHTNFGKREYLRSINNAVTGLTKT 131
            :|.|:|.:....||         |:|..:|..:.:|||.:.            :.|:.:
plant     5 LLMLIICNAVPLQG---------LTKIVSARPQVVNIGSVF------------TFNSLI------ 42

  Fly   132 RGAKLTFLKDYSFEQKNIHFDMMSLTPSPTAILSTLCKEFLR-VNVSAILYMMNNEQFGHS---- 191
             |..:....|.:.|..|         .||:.:.:|..:..:. ...:..:.:|...||..|
plant    43 -GKVIKVAMDAAVEDVN---------ASPSILNTTTLRIIMHDTKYNGFMSIMEPLQFMESETVA 97

  Fly   192 ------TASAQYFLQLAGYLGIPVISWNADNSGLER-------RASQSTLQLQLAPSIEHQSAAM 243
                  :.:|:....:|..|.||::|::|.:..:..       |.||:.|         .|.||:
plant    98 IIGPQRSTTARVVAHVATELKIPILSFSATDPTMSPLQFPFFIRTSQNDL---------FQMAAI 153

  Fly   244 LSILERYKWHQFSVVTSQIAGHDDF----VQAVRERVAEMQEHFKFTILNSIVVTR---TSDLME 301
            ..|::.|.|.:  ||.  |.|.||:    |.|:.:|::|.:....:........||   |..|::
plant   154 ADIVQFYGWRE--VVA--IYGDDDYGRNGVAALGDRLSEKRCRISYKAALPPAPTRENITDLLIK 214

  Fly   302 LVNSEARVMLLYATQTEAITILRAAEEMKLTGENYVWVVSQSVIEKKDAHSQFPV-------GML 359
            :..||:|:::::|:....:.:...|..:.:....|||:.:..:....|..|..|:       |::
plant   215 VALSESRIIVVHASFIWGLELFNVARNLGMMSTGYVWIATNWLSTIIDTDSPLPLDTINNIQGVI 279

  Fly   360 GVHFDTSSAALMNEISNA------IKIYSYGVEAY---------LTDPANRDRRLT-TQSLSCED 408
            .:...|.::.:.......      :.:.:|.:.||         :.|...:...:: :::....:
plant   280 TLRLHTPNSIMKQNFVQRWHNLTHVGLSTYALYAYDTVWLLAQAIDDFFKKGGNVSFSKNPIISE 344

  Fly   409 EGRGR--------WDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSANNKNL 465
            .|.|.        :|.|:||.:.:..|...|...:  ::||:|.:|.:....::|:..:.
plant   345 LGGGNLHLDALKVFDGGKIFLESILQVDRIGLTGR--MKFTSDRNLVNPAFDVLNVIGTG----- 402

  Fly   466 VWEEIGVW----------------KSWETQKLDIRDIAWPGNSHAPPQ-------------GVPE 501
             :..||.|                .|:..|||  ..:.|||:|...|:             |||.
plant   403 -YTTIGYWFNHSGLSVMPADEMENTSFSGQKL--HSVVWPGHSIKIPRGWVFSNNGRHLRIGVPN 464

  Fly   502 KFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGF 566
            ::..:               :.||.|   ..|::                            :||
plant   465 RYRFE---------------EVVSVK---SNGMI----------------------------TGF 483

  Fly   567 CIDLLEKFAEELGFT--YELVRVEDGKWGTLENGKWNGLIADLVNRKT----DMVLTSLMINTER 625
            |:|:.......|.:.  :|||        ...||..|...::||...|    |..:..:.|.|||
plant   484 CVDVFIAAINLLPYAVPFELV--------AFGNGHDNPSNSELVRLITTGVYDAGVGDITIITER 540

  Fly   626 EAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMIF-LFEWLSPS 689
            ..:.||::|::|:|:.:|...|....|..|||.||....|:      |.||:|:|. ...|....
plant   541 TKMADFTQPYVESGLVVVAPVRKLGSSAMAFLRPFTPQMWL------IAAASFLIVGAVIWCLEH 599

  Fly   690 GYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYT 754
            .::.:..      .|.|..:..|:|..::.||.:  |.::......|.:..:|....::..:.||
plant   600 KHNDEFR------GPPRRQVITTFWFSFSTLFFS--HRETTTSNLGRIVLIIWLFVVLIINSSYT 656

  Fly   755 ANLAAFMITREEFHEFSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKT 819
            |:|.:.:...:......|:...:..|.....|...| ...|...:..||....|......:|:|
plant   657 ASLTSILTVHQLSSPIKGIETLQTNHDPIGYPQGSF-VRDYLIHELNIHVSRLVPLRSPEEYDK- 719

  Fly   820 SVAD-----GVAAVLN--GNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKY 877
            ::.|     |||||::  ..::.|:            ...|....||..:...|:|.||.|||..
plant   720 ALRDGPGKGGVAAVVDERAYIELFL------------SNRCEFGIVGQEFTKNGWGFAFPRNSPL 772

  Fly   878 VQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLA 938
            ....:..:|:...|||::|:|..|:.......:......|.|.|:.|...|::.....:||
plant   773 AVDVSAAILQLSENGDMQRIRDKWLLRKACSLQGAEIEVDRLELKSFWGLFVVCGVACVLA 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	84/462 (18%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	90/419 (21%)
		Lig_chan	665..928	CDD:278489	58/270 (21%)
GLR3.6	NP_001326369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910