DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR1.4

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	885	Identity:	177/885 - (20%)
Similarity:	319/885 - (36%)	Gaps:	189/885 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 TAILSTLCKEFLRVN---------------------VSAILYMMNNEQF-----GHSTASAQYFL 199
            |..:|....:|..||                     ::|.:.::..||.     |.|...|:...
plant    63 TTSISMALSDFYHVNNGYRTRVSVLSRDSHGDPLQALAAAMDLLQTEQVEALVGGQSLLEAKNLA 127

  Fly   200 QLAGYLGIPVISWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAG 264
            :|.....:||||.....|.|.  .::....:|.......::..:.::...:.|....::...
plant   128 ELGEKTKVPVISSFQVPSSLS--LAKYNYFIQATHDTSSEAKGIAALFSNFDWRTAVLIYED--- 187

  Fly   265 HDDFVQAVRERVAEMQE---HFKFTILNSIVVTRTSDLMELVNSEA---RVMLLYATQTEAITIL 323
            .||:.::::..|...|:   |.::....|:.......:.:|...:|   |:.:.:.::..|..:.
plant   188 DDDWRESIQPLVGHFQQNAIHIEYKAEFSVSSNEECIMKQLRKFKASGIRIFVAHISERIANRLF 252

  Fly   324 RAAEEMKLTGENYVWVV-SQSVIEKKDAHSQFPVGMLGVHFDTSSAALMNEISNAIKIY--SYGV 385
            ..|..:.:..|.|.|:: ::|:...:|.:......|.||....|...|..|:.|....:  |..:
plant   253 PCARRLGMMEEGYAWILTARSMNNFQDTNYLAKEEMEGVIGFKSYIPLTEELHNFTLRWKRSLRL 317

  Fly   386 EAYLTDPANRDRRLTTQSLSCED--------------EGRGRWDNGEIFFKYLRNVSIEGDLNKP 436
            |..:|       |::..|:...|              .|...:|..|...:..::..:.||:...
plant   318 EEVVT-------RMSVCSIWAHDIAWSLARAAEVAKLPGLSVYDLLEAIPESAKHKGLSGDIKFI 375

  Fly   437 NIEFTADGDLRSAELKIMNLRPSANNKNLVWEEIGVWKSW-----------ETQKLDIRDIAWPG 490
            :.:|.:|      :.:|:|:.....      ..:|:|.|.           .|:.|:  .|.|||
plant   376 DKKFISD------KFEIVNMIGRGE------RSVGLWNSGSFISNRRRRLSSTKALE--TIIWPG 426

  Fly   491 NSHAPP--QGVPEKFHLKITFLEEAPYINLSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQA 553
            .|...|  :.:.||.|.|...|..     |.||..::.:.|             |:..|...|
plant   427 GSTRIPKIRSLKEKRHGKKKKLRV-----LVPAGNITPQIL-------------EVKTDFKTG-- 471

  Fly   554 HRNESFYQCCSGFCIDLLEKFAEELGFTYELVRVEDGKW-GTLENGKWNGLIADLVNRKT--DMV 615
                  ....:|:|||:.|  ...|.|.||   ||...| |.:....:|.|:..|.::|.  |..
plant   472 ------VTAATGYCIDVFE--TSILPFNYE---VEYIPWPGAINYKNYNDLVYTLYSQKDKYDAA 525

  Fly   616 LTSLMINTEREAVVDFSEPFMETGIAIVVAKRTGIISPTAFLEPFDTASWMLVGIVAIQAATFMI 680
            :..:.|...|...|||:.||.:.|:|:|.||..   |.....:|...:.|:.:....|.... ::
plant   526 VGDITITDNRSLYVDFTLPFTDMGLAVVTAKDK---SMWIIFKPLTLSLWLTIASFFILTGA-IV 586

  Fly   681 FLFEWLSPSGYDMKLYLQNTNVTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWALF 745
            :|.|....:.:....:.|...:..:.||.     ||:|       |.:..:...|||:..|| :|
plant   587 WLIERHDNADFQGSCFQQIGTLLCFGFST-----LVFA-------HRERLQHNMSRFVVIVW-IF 638

  Fly   746 AVVFL-AIYTANLAAFMITREEFHEFSGLNDSRLVHPFS---------HKPSFKFGTIPYSHTDS 800
            ||:.| :.|||.|.:.|..:    :..||..:..:..||         ..|:|: |.
plant   639 AVLILTSNYTATLTSVMTVQ----QIRGLKSNENIGFFSASIAANVVNDNPTFQ-GP-------- 690

  Fly   801 TIHKYFNVMHNYMRQYNKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSWYAMT 865
                          :|.....||.....|.....|||.|......|.........:.|.:.....
plant   691 --------------RYKGLKTADDFTNALRNGTISFIVDEVPYVKLFVAKHPSEFVIVETESVTN 741

  Fly   866 GYGLAFSRNSKYVQMFNKRLLEFRANGDLERLRRYWMTGTCRPGKQEHKSSDPLALEQFLSAFLL 930
            |:|.||.:.|..||..::.:.:.|....|:.:..:|..........| .:..||.:..|...|::
plant   742 GFGFAFQKGSPLVQKVSREIEKLRRTEKLKAIENWWFQRQTTSATSE-DTFHPLTVYTFRGLFMI 805

  Fly   931 LMAGILLAALLLL-----------LEHVYFKYIRKRLAKK 959
            .......|.::.|           |:| :.:|:..|.|::
plant   806 TGVSFAFALIVYLIPWNREQRQVVLKH-FHRYVSHRFARE 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	65/388 (17%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	95/418 (23%)
		Lig_chan	665..928	CDD:278489	56/272 (21%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	61/370 (16%)
		ANF_receptor	64..390	CDD:279440	57/343 (17%)
		GluR_Plant	448..778	CDD:270404	91/404 (23%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	57/202 (28%)
		Lig_chan	570..810	CDD:278489	57/281 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910