DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nmdar2 and GLR1.1

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_187061.1	Gene:	GLR1.1 / 819566	AraportID:	AT3G04110	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	943	Identity:	165/943 - (17%)
Similarity:	317/943 - (33%)	Gaps:	330/943 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LSTLCKEFLRVNVSAIL---YMMNNEQFGHSTASAQYFLQLAGYLGIPVISWNADNSGLERRASQ 225
            ||::..:.|..:.:..|   |.:||   |:.|   :..:.:....|.|:|:..|....|:...::
plant    38 LSSIQGKILETSFNLALSDFYGINN---GYRT---RVSVLVRDSQGDPIIALAAATDLLKNAKAE 96

  Fly   226 STLQLQ-------LAPSIEHQSAAMLSI-------LERY----KW-HQFSVVTSQIAGHDDFVQ- 270
            :.:..|       ||...|.....::|.       |::|    :| |.   .||:..|....:|
plant    97 AIVGAQSLQEAKLLATISEKAKVPVISTFLPNTLSLKKYDNFIQWTHD---TTSEAKGITSLIQD 158

  Fly   271 -------AVRERVAEMQEHFKFTILN----SIVVTRT--------------SDLMELVNSEARVM 310
                   .:.|...:..|..:..:.|    .|.:.|:              :.|.:|..|.|.|.
plant   159 FSCKSVVVIYEDADDWSESLQILVENFQDKGIYIARSASFAVSSSGENHMMNQLRKLKVSRASVF 223

  Fly   311 LLYATQTEAITILRAAEEMKLTGENYVWVVS----------------QSVIEKKDAHSQFPVGML 359
            :::.::.....:.:..|::.|..|.:.|:::                |.||..|   |..||...
plant   224 VVHMSEILVSRLFQCVEKLGLMEEAFAWILTARTMNYLEHFAITRSMQGVIGFK---SYIPVSEE 285

  Fly   360 GVHFDTSSAALMNE---------------------ISNAIKIYSY--------GVEAYLTDPANR 395
            ..:|.:.....|.:                     ::||::.:|.        .|.|.|.|....
plant   286 VKNFTSRLRKRMGDDTETEHSSVIIGLRAHDIACILANAVEKFSVSGKVEASSNVSADLLDTIRH 350

  Fly   396 DRRLTTQSLSCEDEGRGRWDNGEIFFKYLRNVSIEGDLNKPNIEFTADGDLRSAELKIMNLRPSA 460
            .|                       ||     .:.||:.      .:|....|...:|:|:....
plant   351 SR-----------------------FK-----GLSGDIQ------ISDNKFISETFEIVNIGREK 381

  Fly   461 NNKNLVWEEIGVWKSWE-TQKLDIRDIAWPGNSHAPP-------QGVPEKFHLKITFLEEAPYIN 517
            ..:      ||:|.... :|:   |.|.|||.|...|       :|..:...:.:|...:.|::.
plant   382 QRR------IGLWSGGSFSQR---RQIVWPGRSRKIPRHRVLAEKGEKKVLRVLVTAGNKVPHLV 437

  Fly   518 LSPADPVSGKCLMDRGVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFTY 582
            ....||.:|                                 ....||||:::.:.......:..
plant   438 SVRPDPETG---------------------------------VNTVSGFCVEVFKTCIAPFNYEL 469

  Fly   583 ELVRVEDGKWGTLENGKWNGLIADLVNR---KTDMVLTSLMINTEREAVVDFSEPFMETGIAIVV 644
            |.:...    |..:|      :|.|::.   |.|..:..:.|.:.|...|||:.|:.:.||.|:.
plant   470 EFIPYR----GNNDN------LAYLLSTQRDKYDAAVGDITITSNRSLYVDFTLPYTDIGIGILT 524

  Fly   645 AKR--TGIISPTAFLEPFDTASWM-------LVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNT 700
            .|:  .|:   ..|.:||:.:.|:       |.|||                       ::|...
plant   525 VKKKSQGM---WTFFDPFEKSLWLASGAFFVLTGIV-----------------------VWLVER 563

  Fly   701 NVTPYRFSLFRTYW------LVW----AVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTA 755
            :|.|.    |:..|      ::|    .::|   .|.:..:..:|||:..||....::..:.|:|
plant   564 SVNPE----FQGSWGQQLSMMLWFGFSTIVF---AHREKLQKMSSRFLVIVWVFVVLILTSSYSA 621

  Fly   756 NLAAF-MITREEFHE---FSGLNDSRLVHPFSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQY 816
            ||.:. .|:|.:.:.   |.|...|.         :.|.|:|      :.:..|..::.
plant   622 NLTSTKTISRMQLNHQMVFGGSTTSM---------TAKLGSI------NAVEAYAQLLR------ 665

  Fly   817 NKTSVADGVAAVLNGNLDSFIYDGTVLDYLVAQDEDCRLMTVGSW---YAMT-------GYGLAF 871
                         :|.|:..|.:...|..|           :|::   :.||       |:|..|
plant   666 -------------DGTLNHVINEIPYLSIL-----------IGNYPNDFVMTDRVTNTNGFGFMF 706

  Fly   872 SRNSKYVQMFNKRLLEFRANGDLERLRRYWM-----------TGTCRPGKQEHKSSDPLALEQFL 925
            .:.|..|...::.:.:.|:.|.|:.:.:.|.           |........:.::|......:..
plant   707 QKGSDLVPKVSREIAKLRSLGMLKDMEKKWFQKLDSLNVHSNTEEVASTNDDDEASKRFTFRELR 771

  Fly   926 SAFLLLMAGILLAALLLLLEHVYFKYIRKRLAK 958
            ..|::..|    |.:|:|..|::  :.|:.:::
plant   772 GLFIIAGA----AHVLVLALHLF--HTRQEVSR 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	73/419 (17%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	79/452 (17%)
		Lig_chan	665..928	CDD:278489	50/304 (16%)
GLR1.1	NP_187061.1	PBP1_GABAb_receptor	31..397	CDD:107361	70/413 (17%)
		ANF_receptor	45..377	CDD:279440	63/377 (17%)
		Periplasmic_Binding_Protein_Type_2	421..737	CDD:304360	77/436 (18%)
		Lig_chan	542..781	CDD:278489	52/317 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910