DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nmdar2 and GLR2.7

DIOPT Version :9

Sequence 1:	NP_001014714.1	Gene:	Nmdar2 / 31107	FlyBaseID:	FBgn0053513	Length:	1083	Species:	Drosophila melanogaster
Sequence 2:	NP_180476.3	Gene:	GLR2.7 / 817460	AraportID:	AT2G29120	Length:	952	Species:	Arabidopsis thaliana

Alignment Length:	1087	Identity:	212/1087 - (19%)
Similarity:	395/1087 - (36%)	Gaps:	317/1087 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GGSLSKGAAANKE--QLNIGLIAP-HTNFGKREYLRSINNAVTGLTKTRGAKLTFLKDYSFEQKN 148
            |..|.:|.....:  ::.:|::.. ||:|.|. .|.|||.:::...|       :..||: .:..
plant    23 GFVLMEGCLGQNQTTEIKVGVVLDLHTSFSKL-CLTSINISLSDFYK-------YHSDYT-TRLA 78

  Fly   149 IHF--DMMSLTPSPTAILSTLCKEFLRVNVSAILYMMNNEQFGHSTA-SAQYFLQLAGYLGIPVI 210
            ||.  .|..:..:.:|.|..:..|    .||||:        |..|: .|::.::||....:|.|
plant    79 IHIRDSMEDVVQASSAALDLIKNE----QVSAII--------GPRTSMQAEFMIRLADKSQVPTI 131

  Fly   211 SWNADNSGLERRASQSTLQLQLAPSIEHQSAAMLSILERYKWHQFSVVTSQIAGHDDFVQAVRER 275
            :::|....|....|...::..|..|  .|..|:.:|::.:.|.  :||...:  .::|.:.:...
plant   132 TFSATCPLLTSINSPYFVRATLDDS--SQVKAIAAIVKSFGWR--NVVAIYV--DNEFGEGILPL 190

  Fly   276 VAEMQEHFKFTILNSIVVTRTS-------DLMELVNSEARVMLLYATQTEAITILRAAEEMKLTG 333
            :.:..:..:..::|..::.:.:       :|.:|:..:.||.:::...|......:.|.|:.:..
plant   191 LTDALQDVQAFVVNRCLIPQEANDDQILKELYKLMTMQTRVFVVHMPPTLGFRFFQKAREIGMME 255

  Fly   334 ENYVWVVSQSVI-----EKKDAHSQFPVGMLGV--HFDTSS---------AALMNEISNAIKIYS 382
            |.|||:::..|:     .::.:..:...|:|||  |...|.         ..:..:..|..::..
plant   256 EGYVWLLTDGVMNLLKSNERGSSLENMQGVLGVRSHIPKSKKLKNFRLRWEKMFPKKGNDEEMNI 320

  Fly   383 YGVEAY--LTDPANRDRRLTTQSLSCEDEGRGRWDN-------------------GEIFFKYLRN 426
            :.:.||  :|..|....:...:||        |:|:                   |....|.|.|
plant   321 FALRAYDSITALAMAVEKTNIKSL--------RYDHPIASGNNKTNLGTLGVSRYGPSLLKALSN 377

  Fly   427 VSIEGDLNKPNIEF-TADGDLRSAELKIMNLRPSANNKNLVWEE--IGVW---------KSWETQ 479
            |...|...    || ..:|.|.|:...::|:..|        ||  ||:|         ||..|.
plant   378 VRFNGLAG----EFELINGQLESSVFDVINIIGS--------EERIIGLWRPSNGIVNAKSKNTT 430

  Fly   480 KL---DIRDIAWPGNSHAPPQG--VPEK-------FHLKITFLEEAPYINLSPADPVSGKCLMDR 532
            .:   .:..:.|||.|...|:|  :|..       ..:|..|||   ::: :..||:|..
plant   431 SVLGERLGPVIWPGKSKDVPKGWQIPTNGKMLRVGIPVKKGFLE---FVD-AKIDPISNA----- 486

  Fly   533 GVLCRVAADHEMAADIDVGQAHRNESFYQCCSGFCIDLLEKFAEELGFT----YELVRVEDGKWG 593
                                        ...:|:||::.|...::|.::    |......|
plant   487 ----------------------------MTPTGYCIEIFEAVLKKLPYSVIPKYIAFLSPD---- 519

  Fly   594 TLENGKWNGLIADLVNRKTDMVLTSLMINTEREAVVDFSEPFMETGIAIVVA----KRTGIISPT 654
              ||  ::.::..:.....|.|:..:.|...|...|||:.|:.|:|::::|.    |.|.:
plant   520 --EN--YDEMVYQVYTGAYDAVVGDVTIVANRSLYVDFTLPYTESGVSMMVPLKDNKNTWV---- 576

  Fly   655 AFLEPFDTASWMLVGIVAIQAATFMIFLFEWLSPSGYDMKLYLQNTNVT---PYRFSLFRTYWLV 716
             ||.|:....|       :..|.|.:|:       |:.:.:.....|..   |....:..::|..
plant   577 -FLRPWSLDLW-------VTTACFFVFI-------GFIVWILEHRVNTDFRGPPHHQIGTSFWFA 626

  Fly   717 WAVLFQAAVHVDSPRGFTSRFMTNVWALFAVVFLAIYTANLAAFMITREEFHEFSGLNDSRLVHP 781
            ::.:..|  |.:......:||:..||....:|.:..|||||.:|...             :|:.|
plant   627 FSTMNFA--HREKVVSNLARFVVLVWCFVVLVLIQSYTANLTSFFTV-------------KLLQP 676

  Fly   782 ----------FSHKPSFKFGTIPYSHTDSTIHKYFNVMHNYMRQYNKTSVAD-------GVAAVL 829
                      |:....::.||                   ::|:..|:...|       |.|.
plant   677 TVTNWKDLIKFNKNIGYQRGT-------------------FVRELLKSQGFDESQLKPFGSAV-- 720

  Fly   830 NGNLDSFIYDGTV---------LDYLVAQDEDCRLMTVGSWYAMTGYGLAFSRNSKYVQMFNKRL 885
              ..|....:||:         :..:::|:.....|...| :...|:|..|.:.|......::.:
plant   721 --ECDELFSNGTITASFDEVAYIKVILSQNSSKYTMVEPS-FKTAGFGFVFPKKSPLTDDVSRAI 782

  Fly   886 LEFRANGDLERLRRYWM--TGTCRPGKQEHKSSDPLALEQFLSAFLLLMAGILLAALLLLLEHV- 947
            |......:::.:...|.  ...| |......||:.|:|..|...||:  |||  |:.|.||..|
plant   783 LNVTQGEEMQHIENKWFKKPNNC-PDLNTSLSSNHLSLSSFWGLFLI--AGI--ASFLALLIFVA 842

  Fly   948 YFKYIRKRLAKKDGGHCCALISLSMGKSLTFRGAV------FEATEILKKHRCNDPICDTHLWKV 1006
            .|.|..|.....|..:             :|||.:      |:..:|           .:|::|
plant   843 NFLYEHKHTLFDDSEN-------------SFRGKLKFLVRNFDEKDI-----------KSHMFK- 882

  Fly  1007 KHELDMSRLRVRQLEKVMDKHGIKAPQLRLASSSDLLNHHHLKERPP 1053
                          |..:  |.:.:| :...|||.|.:......|.|
plant   883 --------------ENAV--HNVSSP-ITQGSSSPLTDQSTPLPRSP 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nmdar2	NP_001014714.1	PBP1_iGluR_NMDA_NR2	99..490	CDD:107373	91/455 (20%)
		PBP2_iGluR_NMDA_Nr2	502..908	CDD:270436	76/451 (17%)
		Lig_chan	665..928	CDD:278489	50/293 (17%)
GLR2.7	NP_180476.3	PBP1_GABAb_receptor	40..421	CDD:107361	87/427 (20%)
		ANF_receptor	54..405	CDD:279440	76/389 (20%)
		GluR_Plant	460..799	CDD:270404	74/441 (17%)
		Lig_chan	584..832	CDD:278489	55/305 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910